All Phenotypes Myf5<tm1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf5^tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857219

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm1Jae/Myf5^tm1Jae	either: 129-Myf5^tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2175124
hm2	Myf5^tm1Jae/Myf5^tm1Jae	involves: 129S4/SvJae	MGI:2168259
hm3	Myf5^tm1Jae/Myf5^tm1Jae	involves: 129S4/SvJae * C57BL/6J	MGI:3713921
ht4	Myf5^tm3.1Thbr/Myf5^tm1Jae	involves: 129S4/SvJae	MGI:3817752
cx5	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Wb/Myf6⁺	involves: 129S1/Sv * 129S4/SvJae	MGI:3714407
cx6	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Thbr/Myf6⁺	involves: 129S4/SvJae	MGI:3714395
cx7	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Eno/Myf6⁺	involves: 129S4/SvJae * 129S7/SvEvBrd	MGI:3714469
cx8	Myf5^tm1Jae/Myf5^tm1Jae Myod1^tm1.1Glh/Myod1⁺	involves: 129/Sv * 129S4/SvJae * C57BL/6J	MGI:3840224
cx9	Myf5^tm1Jae/Myf5^tm1Jae Myod1^tm1.1Glh/Myod1^tm1.1Glh	involves: 129/Sv * 129S4/SvJae * C57BL/6J	MGI:3840223

Allelic Composition	Myf5^tm1Jae/Myf5^tm1Jae
Genetic Background	either: 129-Myf5^tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:3013 )

• die immediately after birth

respiratory system

respiratory failure ( J:3013 )

• unable to breathe

skeleton

abnormal sternocostal joint morphology ( J:3013 )

• ribs do not attach to the sternum due to their truncation

short sternum ( J:3013 )

short ribs ( J:3013 )

• absence of the major distal part of the ribs; the cranial rib stumps on both sides of the vertebral column end in dilated enlarged structures

abnormal sternum ossification ( J:3013 )

• the sternum is completely ossified without sternebral segmentation

embryo

abnormal somite development ( J:3013 )

• appearance of myotomal cells in early somites is delayed by several days

muscle

abnormal muscle morphology ( J:3013 )

• organization of muscles in the anterior thoracic wall is disorganized, probably due to lack of ribs

abnormal myotome development ( J:3013 )

• muscle-specific marker analysis indicates a delay in the development of the myotome

Allelic Composition	Myf5^tm1Jae/Myf5^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternocostal joint morphology ( J:24360 )

• no contacts with the sternum are made because the ribs are short

rib bifurcation ( J:42453 )

short ribs ( J:24360 , J:31636 , J:42453 )

• mutants lack the distal parts of the ribs; ribs are shorter than in Myf6 homozygotes (J:31636)

abnormal sternum ossification ( J:24360 )

• sternum is completely ossified

muscle

absent myotome ( J:42453 )

• no myotomes are detected at E10.5

Allelic Composition	Myf5^tm1Jae/Myf5^tm1Jae
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

fusion of vertebral arches ( J:65301 )

• animals show extensive vertebral arch fusions compared to wild-type

Allelic Composition	Myf5^tm3.1Thbr/Myf5^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myf5^tm3.1Thbr mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:63517 )

N	• skeleton, including ribs is normal

Allelic Composition	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Wb/Myf6⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myf6^tm1Wb mutation (1 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:42453 )

• double heterozygous mice in which the Myf5 and Myf6 alleles are on different chromosomes show severely reduced expression of Myf5 and die at birth due to respiratory distress

respiratory system

respiratory distress ( J:42453 )

skeleton

abnormal sternebra morphology ( J:42453 )

• sternum shows irregular ossification of sternebrae

abnormal sternocostal joint morphology ( J:42453 )

• none of the first seven ribs are attached to the sternum

abnormal rib morphology ( J:42453 )

rib bifurcation ( J:42453 )

rib fusion ( J:42453 )

• fusion of adjacent ribs

short ribs ( J:42453 )

• short ribs; ribs are shorter than in wild-type or Myf6 homozygotes but longer than the stubs of Myf5 homozygotes

muscle

abnormal myotome development ( J:42453 )

• myotomes are disorganized at E10.5

Allelic Composition	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Thbr/Myf6⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myf6^tm1Thbr mutation (0 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:31636 )

• double heterozygous mice that carry the Myf5 and Myf6 alleles on different chromosomes and express drastically reduced levels of Myf5 mRNA do not survive to weaning and when delivered by cesarean section at E18.5, the pups die within a few minutes after delivery

skeleton

short ribs ( J:31636 )

• mutants lack the distal parts of the ribs

• the average rib length is between that of Myf6 and Myf5 homozygotes

Allelic Composition	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Eno/Myf6⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:42453 )

• 63% of double heterozygous mice, in which the Myf5 and Myf6 alleles are on different chromosomes and show severely reduced expression of Myf5, die immediately after birth; the rest survive

skeleton

abnormal sternocostal joint morphology ( J:42453 )

• attachment failure of at least one rib to the sternum is seen in most mutants, although the identity of the affected rib(s) and the number of ribs affected varies

abnormal rib morphology ( J:42453 )

• abnormal ribs

muscle

abnormal myotome development ( J:42453 )

• number of myocytes in the myotomes is reduced at E10.5 and the conformation of the myotome is abnormal

Allelic Composition	Myf5^tm1Jae/Myf5^tm1Jae Myod1^tm1.1Glh/Myod1⁺
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myod1^tm1.1Glh mutation (0 available); any Myod1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle development ( J:87370 )

• trunk musculature is disorganized compared to in wild-type mice

• expression of Myod1 is delayed at E10.5 compared to in wild-type mice

• however, the Pax3-mediated recovery of Myod1 is normal

Allelic Composition	Myf5^tm1Jae/Myf5^tm1Jae Myod1^tm1.1Glh/Myod1^tm1.1Glh
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle development ( J:87370 )

• trunk musculature is disorganized compared to in wild-type mice

• expression of Myod1 is delayed at E10.5 compared to in wild-type mice

• however, the Pax3-mediated recovery of Myod1 is normal

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