Phenotypes associated with this allele

• Allele Symbol: Myf6^tm1Wb
• Allele Name: targeted mutation 1, Barbara Wold
• Allele ID: MGI:1857220
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf6^tm1Wb/Myf6^tm1Wb	involves: 129S1/Sv * C57BL/6	MGI:2175131
cx2	Myf5^tm1Jae/Myf5^+ Myf6^tm1Wb/Myf6^+	involves: 129S1/Sv * 129S4/SvJae	MGI:3714407

Genotype
MGI:2175131

hm1

• Allelic Composition: Myf6^tm1Wb/Myf6^tm1Wb
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:29279 )

• die shortly after birth

respiratory system

respiratory distress ( J:29279 )

• unable to breathe

skeleton

abnormal sternocostal joint morphology ( J:29279 )

• rib foreshortening leads to variable failure to join the sternum

abnormal rib morphology ( J:29279 )

• rib development is severely disturbed in newborns

• some ribs display abnormal angles of extension

rib bifurcation ( J:29279 )

rib fusion ( J:29279 )

• fusion of rib cartilage from adjacent ribs

short ribs ( J:29279 )

• rib foreshortening in ribs 2-12 is usually less than 20% of total length and leads to variable failure to join the sternum

• the first and last ribs are more dramatically shortened compared to others

truncated ribs ( J:29279 )

• truncated ribs that fail to attach to the sternum

abnormal cervical vertebrae morphology ( J:29279 )

• the tuberculum anterior is absent on the 6th cervical vertebrae of most mice

abnormal sternum ossification ( J:29279 )

• disorganized ossification in the sternum

muscle

abnormal myotome development ( J:29279 )

• although earliest myotome formation is unaffected, mutants exhibit a deficit in myotome development beginning around E9 and ending around E11

abnormal myotome morphology ( J:29279 )

• myotomes are greatly reduced in size and cell number at E11

abnormal intercostal muscle morphology ( J:29279 )

• some intercostals muscles associated with ribs 35 are either disorganized or significantly reduced in fiber number at E18.5 and in newborns

Genotype
MGI:3714407

cx2

• Allelic Composition: Myf5^tm1Jae/Myf5⁺; Myf6^tm1Wb/Myf6⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae

mortality/aging

perinatal lethality, complete penetrance ( J:42453 )

• double heterozygous mice in which the Myf5 and Myf6 alleles are on different chromosomes show severely reduced expression of Myf5 and die at birth due to respiratory distress

respiratory system

respiratory distress ( J:42453 )

skeleton

abnormal sternebra morphology ( J:42453 )

• sternum shows irregular ossification of sternebrae

abnormal sternocostal joint morphology ( J:42453 )

• none of the first seven ribs are attached to the sternum

abnormal rib morphology ( J:42453 )

rib bifurcation ( J:42453 )

rib fusion ( J:42453 )

• fusion of adjacent ribs

short ribs ( J:42453 )

• short ribs; ribs are shorter than in wild-type or Myf6 homozygotes but longer than the stubs of Myf5 homozygotes

muscle

abnormal myotome development ( J:42453 )

• myotomes are disorganized at E10.5