All Phenotypes Ngfr<tm1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ngfr^tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857226

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ngfr^tm1Jae/Ngfr^tm1Jae	B6.129S4-Ngfr^tm1Jae	MGI:3044432
hm2	Ngfr^tm1Jae/Ngfr^tm1Jae	B6.129S4-Ngfr^tm1Jae/J	MGI:3702322
hm3	Ngfr^tm1Jae/Ngfr^tm1Jae	C;129S-Ngfr^tm1Jae/J	MGI:2175146
hm4	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129 * BALB/c	MGI:3531406
hm5	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S1/Sv * 129S4/SvJae	MGI:3835511
hm6	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae	MGI:3770685
hm7	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae * BALB/c	MGI:3770677
hm8	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae * C57BL/6	MGI:3809496
hm9	Ngfr^tm1Jae/Ngfr^tm1Jae	involves: 129S4/SvJae * C57BL/6J	MGI:3719110
ht10	Ngfr^tm1Jae/Ngfr⁺	B6.129S4-Ngfr^tm1Jae	MGI:3770684
cx11	Ngf^tm1.1Blhe/Ngf⁺ Ngfr^tm1Jae/Ngfr^tm1Jae	B6.Cg-Ngf^tm1.1Blhe Ngfr^tm1Jae	MGI:5461512
cx12	Ngfr^tm1Jae/Ngfr^tm1Jae Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3770689
cx13	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae	involves: 129S4/SvJae	MGI:3770686
cx14	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3^tm1Jae	involves: 129S4/SvJae * BALB/c	MGI:3770678
cx15	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3⁺	involves: 129S4/SvJae * BALB/c	MGI:3770676
cx16	Ngfr^tm1Jae/Ngfr⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723452
cx17	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723445
cx18	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723454
cx19	Ngfr^tm1Jae/Ngfr^tm1Jae Sema3a^tm1Mcf/Sema3a⁺	involves: 129S4/SvJae * C57BL/6	MGI:3770681
cx20	Ngfr^tm1Jae/Ngfr^tm1Jae Sema3a^tm1Mcf/Sema3a^tm1Mcf	involves: 129S4/SvJae * C57BL/6	MGI:3770682

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	B6.129S4-Ngfr^tm1Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:90280 )

• areas of the epithelium of the tongue lack innervation and the filiform papillae are sparsely innervated

• the axons in the tongue display reduced branching and smaller terminal arbors

abnormal neuron morphology ( J:128451 )

• like wild-type neurons, cultured superior cervical ganglion neurons are resistant to apoptosis induced by pro-NGF and pro-BDNF

• the number of sympathetic neurons is increased 33% at P4 and 39% at P15 compared to in wild-type mice

• at 60 weeks sympathetic neuron cell bodies are 25% smaller than in wild-type mice

• unlike in wild-type mice, superior cervical ganglion are protected from age-related apoptosis

abnormal neuron differentiation ( J:127639 )

• peripheral nerves in the hindlimb, forelimb, and trigeminal ganglia are severely stunted compared to in wild-type mice

abnormal axon extension ( J:127639 )

• growth cones from dorsal root ganglion neurons are more sensitive to Sema3A repulsion than wild-type neurons

• when treated with 15 pM Sema3A outgrowth rate inhibition is increased (15 um per hour compared to 35 um per hour for wild-type neurons)

• however, increased sensitivity to Sema3A repulsion is alleviated in a double heterozygote cross of Ngfr and Sema3A

abnormal sensory neuron innervation pattern ( J:90280 )

• innervation of the somatosensory prominences is reduced

• innervation of the fungiform papillae are reduced

• at P0 there are 35% fewer geniculate ganglion neurons that supply taste neurons to the fungiform papillae in homozygotes compared to wild-type mice

increased neuron number ( J:128451 )

• the number of sympathetic neurons is increased 33% at P4 and 39% at P15 compared to in wild-type mice

increased retina photoreceptor cell number ( J:115542 )

• after 2 weeks of light exposure, the number of rows of photoreceptors is 4.6+/-0.31 rows compared to 2.3+/-0.25 in wild-type mice and 21.2+/-0.25 in homozygous mice

• after 3 weeks of light exposure, the number of rows of photoreceptors is 3.0+/-0.41 rows compared to 1.5+/-0.24 in wild-type mice and 0.9+/-0.28 in homozygous mice

digestive/alimentary system

abnormal tongue epithelium morphology ( J:90280 )

• at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions

abnormal circumvallate papillae morphology ( J:90280 )

• the vallate papilla is deformed and small in neonatal mutants

• at P7 the vallate trench is only 60% as deep as in wild-type mice

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice

• homozygous mice have fewer fungiform taste buds than wild-type mice

cardiovascular system

abnormal Kupffer cell morphology ( J:120368 )

• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice

abnormal vascular wound healing ( J:109753 )

• formation of neointimal lesions is enhanced 2 and 4 weeks after ligation compared to in wild-type mice such that there is a 2- to 4-fold increase in intimal to medial ratio at 500 um and 1.0 mm proximal to the ligation

• however, infiltration of inflammatory cells is normal

• apoptosis in neointimal lesions is decreased by 60% to 70%

taste/olfaction

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice

• homozygous mice have fewer fungiform taste buds than wild-type mice

immune system

abnormal Kupffer cell morphology ( J:120368 )

• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:112769 )

• mice have an increased risk of developing severe experimental autoimmune encephalomyelitis compared to wild-type mice

• B220+ B cells make up 6% of cells in the inflammatory cuffs compared to 15% in wild-type mice immunized with MOG35-55

• the population of Iba-1+ cells in the inflammatory cuffs is reduced by 10% compared to in wild-type mice immunized with MOG35-55

• polymorphonuclear cells are reduced by half compared to in wild-type mice immunized with MOG35-55

• microglial/macrophage and neutrophil numbers in the inflammatory infiltrate are reduced 68% to 40% while the size of the inflitratory cuffs is normal or even larger than in wild-type mice

• however, the number of double-positive (monocyte) cells is normal

• mice display considerable infiltration of fibronectin into the spinal cord parenchyma

homeostasis/metabolism

abnormal vascular wound healing ( J:109753 )

• however, infiltration of inflammatory cells is normal

• apoptosis in neointimal lesions is decreased by 60% to 70%

liver/biliary system

abnormal Kupffer cell morphology ( J:120368 )

• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice

vision/eye

increased retina photoreceptor cell number ( J:115542 )

• after 2 weeks of light exposure, the number of rows of photoreceptors is 4.6+/-0.31 rows compared to 2.3+/-0.25 in wild-type mice and 21.2+/-0.25 in homozygous mice

• after 3 weeks of light exposure, the number of rows of photoreceptors is 3.0+/-0.41 rows compared to 1.5+/-0.24 in wild-type mice and 0.9+/-0.28 in homozygous mice

hematopoietic system

abnormal Kupffer cell morphology ( J:120368 )

• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice

craniofacial

abnormal tongue epithelium morphology ( J:90280 )

• at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions

abnormal circumvallate papillae morphology ( J:90280 )

• the vallate papilla is deformed and small in neonatal mutants

• at P7 the vallate trench is only 60% as deep as in wild-type mice

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice

• homozygous mice have fewer fungiform taste buds than wild-type mice

cellular

abnormal neuron differentiation ( J:127639 )

• peripheral nerves in the hindlimb, forelimb, and trigeminal ganglia are severely stunted compared to in wild-type mice

abnormal axon extension ( J:127639 )

• growth cones from dorsal root ganglion neurons are more sensitive to Sema3A repulsion than wild-type neurons

• when treated with 15 pM Sema3A outgrowth rate inhibition is increased (15 um per hour compared to 35 um per hour for wild-type neurons)

• however, increased sensitivity to Sema3A repulsion is alleviated in a double heterozygote cross of Ngfr and Sema3A

growth/size/body

abnormal tongue epithelium morphology ( J:90280 )

• at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions

abnormal circumvallate papillae morphology ( J:90280 )

• the vallate papilla is deformed and small in neonatal mutants

• at P7 the vallate trench is only 60% as deep as in wild-type mice

abnormal gustatory papilla taste bud morphology ( J:90280 )

• at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice

• homozygous mice have fewer fungiform taste buds than wild-type mice

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	B6.129S4-Ngfr^tm1Jae/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced infarct size in Ngfr^tm1Jae/Ngfr^tm1Jae mice after cardiac ischemia-reperfusion surgery

hearing/vestibular/ear

cochlear hair cell degeneration ( J:110434 )

• by 6 months, male homozygotes exhibit absence or damage of cochlear HCs in both the basal and upper turns

• however, IHCs are still present and morphologically normal at 4 months, suggesting that SGN's dendrites connecting the IHCs are damaged earlier than IHCs

organ of Corti degeneration ( J:110434 )

• at 1 month of age, male homozygotes exhibit a grossly normal organ of the Corti, except for a slight reduction in the number of SGNs

• by 6 months, male homozygotes show complete degeneration of the organ of Corti in the basal turns

increased or absent threshold for auditory brainstem response ( J:110434 )

• at 4 months of age, male homozygotes exhibit a significant elevation (>33 dB SPL) in click-evoked ABR thresholds relative to wild-type males

• at 6 months and 1 year, male homozygotes continue to display significant increases in ABR thresholds relative to age-matched wild-type males (100 and 126 dB SPL, respectively)

• however, no significant differences in click-evoked ABR thresholds are observed at 1 month, consistent with a normal cochlear structure at this age

increased susceptibility to age-related hearing loss ( J:110434 )

• starting at 4 months, male homozygotes display an age-related progressive hearing loss relative to age-matched wild-type males

• by 1 year of age, homozygotes are unresponsive to click stimuli at the maximum level (136 dB SPL)

sensorineural hearing loss ( J:110434 )

• male homozygotes show progressive hearing loss at 4 months, when both SGN degeneration and hair cell loss are observed in the basal cochlear turn

nervous system

cochlear hair cell degeneration ( J:110434 )

• by 6 months, male homozygotes exhibit absence or damage of cochlear HCs in both the basal and upper turns

• however, IHCs are still present and morphologically normal at 4 months, suggesting that SGN's dendrites connecting the IHCs are damaged earlier than IHCs

cochlear ganglion degeneration ( J:110434 )

• starting at 1 month, male homozygotes show a slight (15.7%) but progressive loss of SGNs from the basal to the apical cochlear turns

• at 4 months, male homozygotes display significant SGN degeneration in the basal cochlear turn and swelling of the afferent dendrites below IHCs in the middle turns

• by 6 months, the density of SGNs is significantly reduced in the middle and basal turns, with a 59.8% loss of SGNs in the most basal turns

cardiovascular system

decreased myocardial infarct size ( J:190893 )

• 10 days after myocardial ischemic/reperfusion injury

homeostasis/metabolism

decreased myocardial infarct size ( J:190893 )

• 10 days after myocardial ischemic/reperfusion injury

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	C;129S-Ngfr^tm1Jae/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron apoptosis ( J:46125 )

• reduced levels of neuronal cell death

cellular

abnormal neuron apoptosis ( J:46125 )

• reduced levels of neuronal cell death

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	involves: 129 * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:96121 )

• reduced inhibition by myelin of neurite outgrowth from dorsal root ganglion neurons, but not cerebellar neurons, compared to heterozygous controls, indicating that mutant neurons are much less sensitive to myelin

• reduced inhibition by Nogo-66 (Rtn4) peptide of neurite outgrowth from P7 cerebellar neurons compared with heterozygous controls, however homozygotes did not show enhanced regeneration of corticospinal tract axons in comparison with wild-type after spinal dorsal hemisection

cellular

abnormal axon extension ( J:96121 )

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal superior colliculus morphology ( J:145459 )

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal retina ganglion cell morphology ( J:145459 )

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

vision/eye

abnormal retina ganglion cell morphology ( J:145459 )

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice

• nearly all neurons cultured with NT4 survive unlike wild-type neurons

abnormal axon guidance ( J:145459 )

• when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons

• however, avoidance of stripes with EPHA5-Fc is normal

abnormal superior colliculus morphology ( J:145459 )

• however, total area of the superior colliculus is normal

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal sensory neuron innervation pattern ( J:43749 )

• absence of sensory innervation to pineal and sweat glands

abnormal cholinergic neuron morphology ( J:62379 )

• increased size of cholinergic forebrain neurons

abnormal retina ganglion cell morphology ( J:145459 )

• 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal trigeminal ganglion morphology ( J:157604 )

• ophthalmic branch of the trigeminal ganglion is severely truncated at E12.5

behavior/neurological

abnormal spatial learning ( J:62379 )

• spatial learning is improved compared to in wild-type mice without deterioration with age

vision/eye

abnormal retina ganglion cell morphology ( J:145459 )

• 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice

• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice

• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

abnormal eye physiology ( J:157549 )

• mice subjected to intraocular injection of the pro form of nerve growth factor are protected from induced retinal ganglion cell death

homeostasis/metabolism

abnormal tumor necrosis factor level ( J:157549 )

• the pro form of nerve growth factor fails to induce TNF expression in retinas

immune system

abnormal tumor necrosis factor level ( J:157549 )

• the pro form of nerve growth factor fails to induce TNF expression in retinas

cellular

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice

• nearly all neurons cultured with NT4 survive unlike wild-type neurons

abnormal axon guidance ( J:145459 )

• when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons

• however, avoidance of stripes with EPHA5-Fc is normal

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased muscle spindle number ( J:53825 )

• spindle density in the soleus, but no the medial gastrocnemius, plantaris and lumbrical muscles, is reduced 50% compared to in wild-type mice

abnormal sensory neuron innervation pattern ( J:42087 , J:43748 )

• at 3 to 5 months, Pde6a+ pulpal neurons are decreased (J:42087)

• the dermis of fore- and hindlimb paws either lacks or have reduced numbers of Pde6a+ sensory fibers and small-diameter nerves are absent (J:43748)

• only a few single fibers are present in the subepidermis and none are detected in the epidermis of fore- and hindlimb paws (J:43748)

• reduced innervation is not restricted to hairless patches (J:43748)

• however, sympathetic innervation of the iris and salivary glands is normal (J:43748)

abnormal dorsal root ganglion morphology ( J:53825 )

• mice exhibit a loss of myelinated fibers in the dorsal root ganglion

abnormal proprioceptive neuron morphology ( J:53825 )

• mice exhibit a 50% loss of proprioreceptive neurons in L4 of the dorsal root ganglion

small L4 dorsal root ganglion ( J:53825 )

• at E14.5, L4 is smaller than in wild-type mice due to a 7.5-fold increase in apoptosis

skeleton

abnormal tooth morphology ( J:42087 )

• increased signs of wear on molars

abnormal molar morphology ( J:42087 )

• mandibular molar occlusal facets are longer than in wild-type mice

abnormal molar crown morphology ( J:42087 )

• maxillary molar crown height is reduced by 15%

• however, full height of teeth is normal

muscle

abnormal muscle morphology ( J:53825 )

• muscles exhibit fewer myelinated fibers than in wild-type mice (36+/-2 compared to 76+/-2 in wild-type mice)

decreased muscle spindle number ( J:53825 )

• spindle density in the soleus, but no the medial gastrocnemius, plantaris and lumbrical muscles, is reduced 50% compared to in wild-type mice

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:43748 )

• prolonged latency in hot plate test

homeostasis/metabolism

extremity edema ( J:43748 )

• at 4 months of age, mice exbihit edema in the fore- and hindlimb paws

limbs/digits/tail

ulcerated autopod ( J:43748 )

• at 4 months of age, fore- and hindlimb paws become edematous and develop severe ulcers

• ulcers progress more proximally

• ulcers are complicated by secondary infections that result in the lose of toenails and hair

• epidermis and epidermal structures are lost from areas affected by ulcers

• excessive epidermal proliferation is present at the edges of ulcers

renal/urinary system

renal/urinary system phenotype ( J:43748 )

N	• unlike in studies using p75^NGFR oligonucleotide knockdown, kidney function is normal

craniofacial

abnormal tooth morphology ( J:42087 )

• increased signs of wear on molars

abnormal molar morphology ( J:42087 )

• mandibular molar occlusal facets are longer than in wild-type mice

abnormal molar crown morphology ( J:42087 )

• maxillary molar crown height is reduced by 15%

• however, full height of teeth is normal

abnormal oral cavity morphology ( J:42087 )

• the height of the oral cavity is reduced

integument

absent hair follicles ( J:43748 )

• loss of follicles, at distal extremities, progressive to more proximal regions

growth/size/body

abnormal tooth morphology ( J:42087 )

• increased signs of wear on molars

abnormal molar morphology ( J:42087 )

• mandibular molar occlusal facets are longer than in wild-type mice

abnormal molar crown morphology ( J:42087 )

• maxillary molar crown height is reduced by 15%

• however, full height of teeth is normal

abnormal oral cavity morphology ( J:42087 )

• the height of the oral cavity is reduced

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:139381 )

• axons of mutant neurons grown in vitro in the presence of NGF grow equally well regardless if they are stimulated or not in contrast to wild-type neurons where stimulated axons out compete non-stimulated axons

• this lack of growth disadvantage in non-stimulated axons is due to less axon degeneration than occurs to wild-type neurons

abnormal axon pruning ( J:139381 )

• sympathetic neurons of the superior cervical ganglion (SCG) have improper pruning of axons from neurons that reach into both eye compartments

• SCG neurons in wild-type mice reduce through axon pruning the number of neurons projecting to both eyes from 78% at p20 to 20% at p50

• mutant mice have a similar percentage of SCG neurons that connect to both eyes at P20 but this percentage does not decrease with age

• at p35 where SCG neurons are actively pruning exons in wild-type mice, mutant mice have significantly less degenerating SCG axons than in wild-type mice

cellular

abnormal axon extension ( J:139381 )

• this lack of growth disadvantage in non-stimulated axons is due to less axon degeneration than occurs to wild-type neurons

abnormal axon pruning ( J:139381 )

• sympathetic neurons of the superior cervical ganglion (SCG) have improper pruning of axons from neurons that reach into both eye compartments

• SCG neurons in wild-type mice reduce through axon pruning the number of neurons projecting to both eyes from 78% at p20 to 20% at p50

• mutant mice have a similar percentage of SCG neurons that connect to both eyes at P20 but this percentage does not decrease with age

• at p35 where SCG neurons are actively pruning exons in wild-type mice, mutant mice have significantly less degenerating SCG axons than in wild-type mice

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:116954 )

• the number of motor neurons in tibial nerve is reduced

abnormal peripheral nervous system regeneration ( J:116954 )

• motor axonal regeneration is increased in the tibial nerve cross-suture

Allelic Composition	Ngfr^tm1Jae/Ngfr⁺
Genetic Background	B6.129S4-Ngfr^tm1Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:127639 )

• nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfr^tm1Jae homozygotes

abnormal axon extension ( J:127639 )

• neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfr^tm1Jae homozygotes

respiratory system

decreased airway responsiveness ( J:115419 )

• unlike in exposed wild-type mice IL-4 and IL-5 production is not increased

• unlike in exposed wild-type mice, no pulmonary eosinophilic inflammation is observed

• unlike in wild-type mice, no airway hyper-responsiveness was observed following exposure to Ach and ovalbumin (50% brionchiorestriction occurs at 580 ug per kg for Ach and 586 ug per kg ovalbulmin compared to 552 ug per kg Ach and 62.5 ug per kg ovalbumin for wild-type mice)

• total leukocytes, eosinophils and lymphocytes do not increase as in wild-type following exposure to provocation agent

• while IgE levels increase following exposure to provocation they do not increase as much as in wild-type mice

• however, interferon-gamma production following exposure to provocation agent is normal

cellular

abnormal neuron differentiation ( J:127639 )

• nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfr^tm1Jae homozygotes

abnormal axon extension ( J:127639 )

• neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfr^tm1Jae homozygotes

Allelic Composition	Ngf^tm1.1Blhe/Ngf⁺ Ngfr^tm1Jae/Ngfr^tm1Jae
Genetic Background	B6.Cg-Ngf^tm1.1Blhe Ngfr^tm1Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Ngf^tm1.1Blhe mutation (0 available); any Ngf mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Adult Ngf^tm1.1Blhe/Ngf⁺ mice exhibit dilated cardiomyopathy and fibrosis and this phentoype is rescued in Ngfr^tm1Jae/Ngfr^tm1Jae Ngf^tm1.1Blhe/Ngf⁺ mice

cardiovascular system

cardiovascular system phenotype ( J:190893 )

N	• unlike Ngf^tm1.1Blhe heterozygotes, mice do not exhibit ventricular dilation, fibrosis cardiac hypocontractility or premature death

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Plg^tm1Jld/Plg^tm1Jld
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Plg^tm1Jld mutation (2 available); any Plg mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120368 )

• median survival is 2.5 months

liver/biliary system

increased hepatocyte apoptosis ( J:120368 )

• mice exhibit apoptosis in the liver that is restricted to hepatocytes

increased hepatocyte proliferation ( J:120368 )

• the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice)

hepatic necrosis ( J:120368 )

• mice exhibit prominent liver lesions at 10 weeks with large necrotic lesions

growth/size/body

decreased body size ( J:120368 )

• at 5 weeks of age

cellular

increased hepatocyte apoptosis ( J:120368 )

• mice exhibit apoptosis in the liver that is restricted to hepatocytes

increased hepatocyte proliferation ( J:120368 )

• the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice)

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Ntf5^tm1Jae mutation (1 available); any Ntf5 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice

cellular

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3^tm1Jae
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Ntf3^tm1Jae mutation (2 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:53825 )

• mice die at birth

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf3^tm1Jae/Ntf3⁺
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:53825 )

• few mice survive past 3 weeks of age

nervous system

decreased muscle spindle number ( J:53825 )

• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice

absent muscle spindles ( J:53825 )

• 31% of soleus muscles are devoid of muscle spindles

decreased sensory neuron number ( J:53825 )

• mice exhibit a 78% loss in sensory neurons in the dorsal root ganglion

abnormal dorsal root ganglion morphology ( J:53825 )

• mice exhibit a loss of 82% myelinated fibers in the dorsal root ganglion

• mice exhibit a loss of 75% of dorsal root ganglion neurons

abnormal proprioceptive neuron morphology ( J:53825 )

• at E14.5, Ia neuron projections in the dorsal root ganglion are severely reduced

• mice exhibit a 90% loss of proprioreceptive neurons in the dorsal root ganglion

small L4 dorsal root ganglion ( J:53825 )

• at E14.5, L4 is smaller than in wild-type mice due to a 12.1-fold increase in apoptosis

behavior/neurological

dystonia ( J:53825 )

• mice exhibit dystonia during the first two weeks after birth but not during adulthood

ataxia ( J:53825 )

• mice exhibit ataxia during the first two weeks after birth but not during adulthood

abnormal gait ( J:53825 )

• mice exhibit an unstable gait and mild posturing of extremities during the first two weeks after birth but not during adulthood

muscle

dystonia ( J:53825 )

• mice exhibit dystonia during the first two weeks after birth but not during adulthood

abnormal muscle morphology ( J:53825 )

• muscles exhibit fewer myelinated fibers than in wild-type mice (26+/-2 compared to 76+/-2 in wild-type mice)

decreased muscle spindle number ( J:53825 )

• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice

absent muscle spindles ( J:53825 )

• 31% of soleus muscles are devoid of muscle spindles

muscle spasm ( J:53825 )

• mice that survive longer than 3 weeks exhibit flexor spasms and uplifting of hindlimbs during weeks 3 to 4

growth/size/body

decreased body weight ( J:53825 )

• mice weight 10% to 30% less than wild-type mice

Allelic Composition	Ngfr^tm1Jae/Ngfr⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)2Gogo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-tetX,lacZ)1Gogo/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Sema3a^tm1Mcf/Sema3a⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Sema3a^tm1Mcf mutation (0 available); any Sema3a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:127639 )

N	• at E12.5, mice exhibit normal neuron growth that is increased 3-fold in hindlimbs, 2.7-fold in forelimbs and 4.4-fold in trigeminal ganglion compared to Ngfr^tm1Jae homozygotes

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Sema3a^tm1Mcf/Sema3a^tm1Mcf
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:127639 )

• peripheral axons overshot the front observed in wild-type mice

• axon density is increased 2.28-fold in hindlimbs and 1.71-fold in forelimbs compared to in wild-type mice but not as much as in Sema3a^tm1Mcf homozygotes (5.97-fold in hindlimbs and 3.74-fold in forelimbs)

• increased sensitivity to Sema3A repulsion in Ngfr^tm1Jae homozygotes is alleviated

cellular

abnormal neuron differentiation ( J:127639 )

• peripheral axons overshot the front observed in wild-type mice

• increased sensitivity to Sema3A repulsion in Ngfr^tm1Jae homozygotes is alleviated

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