Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nos3tm1Unc targeted mutation 1, University of North Carolina MGI:1857229 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• kainic acid injection of hippocampi does not cause blood-brain barrier breakdown
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• kainic acid injection of hippocampi does not cause blood-brain barrier breakdown
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 40% die within the first hour of birth
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• 85% of mice die by P10 compared with 13% of wild-type mice
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• in response to transverse aortic constriction (TAC)-induced pressure overload, wild-type hearts exhibit a progressive cardiac hypertrophy with significant dilatory remodeling whereas mutant hearts show more modest and concentric cardiac hypertrophy at 3 weeks, with minimal further progression
• at 9 weeks after TAC, mutant hearts develop significantly less intestitial fibrosis, myocyte hypertrophy, and fetal gene re-expression (B-natriuretic peptide and alpha-skeletal actin) relative wild-type hearts
• however, homozygotes show no significant differences in baseline heart weight or myocyte size relative to wild-type mice
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• fetuses from E18 to term demonstrate slight growth retardation
(J:98913)
• Intrauterine Growth Retardation demonstrated by ultrasonographic imaging showing differences in embryo and gestational vesicle measurements in both longitudinal and transversal curves from Days 5.5 to 14.5.
(J:140819)
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• after remnant kidney surgery, homozygotes exhibit a significantly greater endothelial cell loss than similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes exhibit a significantly greater decrease (50%) in endothelial cell density in the glomeruli and renal cortex relative to similarly-treated wild-type controls
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• abnormalities in pulmonary vascular development
• disorganization of the extracellular matrix structure in the lung vasculature
• capillaries of preterm mice remain deep within thickened septae, instead of aligning with the saccular epithelium, resulting in significantly fewer capillaries abutting saccular airspaces
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• severe with focal alveolar edema
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• impaired pulmonary angiogenesis
• occasionally exhibit misalignment of pulmonary veins, which are seen in anomalous locations adjacent to the lung pleura, running alongside arterial vessels and sharing a common adventitial sheath
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• E19.5 lungs show dramatic decrease of arteriolar branches and regions of marked capillary hypoperfusion
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• diastolic dimension is increased compared to in wild-type mice
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• membranous and muscular ventricular defects in 6 of 10 mice compared with 1 of 10 atrial septal defects in wild-type mice
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• in response to transverse aortic constriction (TAC)-induced pressure overload, wild-type hearts exhibit a progressive cardiac hypertrophy with significant dilatory remodeling whereas mutant hearts show more modest and concentric cardiac hypertrophy at 3 weeks, with minimal further progression
• at 9 weeks after TAC, mutant hearts develop significantly less intestitial fibrosis, myocyte hypertrophy, and fetal gene re-expression (B-natriuretic peptide and alpha-skeletal actin) relative wild-type hearts
• however, homozygotes show no significant differences in baseline heart weight or myocyte size relative to wild-type mice
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• high incidence (5 of 12) bicuspid aortic valves, however do not exhibit aortic coarctation
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• ventricular hypertrophy
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• after remnant kidney surgery, homozygotes develop microaneurysms unlike similarly-treated wild-type controls
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• E16 lungs show scattered areas of parenchymal and interlobar hemorrhages
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• at 9 weeks of TAC, wild-type hearts exhibit a rightward shift of LV pressure-volume (PV) loops and end-systolic and end-diastolic PV relations reflecting remodeling; in contrast, mutant hearts display a leftward shift with smaller end-diastolic and end-systolic chamber volumes, as well as preserved wall thickness and fractional shortening, indicating preserved or enhanced systolic and diastolic function
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• in fetal atrioventricular endothelial cushions, septum primum and right and left ventricular myocardium
• at E12.5, E15.5 and P1 in the myocardium
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• in response to TAC-induced pressure overload, homozygotes exhibit a similar or greater rise in LV systolic pressure and ventricular afterload (arterial elastance [Ea]) at 9 weeks relative to wild-type mice
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• at 2 months after right subcapsular nephrectomy and surgical resection of the poles of the left kidney to produce a remnant kidney (RK) model, homozygotes fail to exhibit a further increase in systolic blood pressure relative to sham-operated homozygotes, unlike wild-type controls
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• E16 lungs show scattered areas of parenchymal and interlobar hemorrhages
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• fetal lungs demonstrate abnormally compact lung structure and lungs of pups show evidence of septal thickening and reduced airspaces
• E20 lungs display absence of discernible basement membrane in the distal airways
• exhibit a decrease in apoptosis in the lungs
• E16 lungs display scattered subpleural hematomas
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• abnormalities in pulmonary vascular development
• disorganization of the extracellular matrix structure in the lung vasculature
• capillaries of preterm mice remain deep within thickened septae, instead of aligning with the saccular epithelium, resulting in significantly fewer capillaries abutting saccular airspaces
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• severe with focal alveolar edema
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• observe an increase in markedly swollen glycogen laden pneumocytes protruding into airspaces compared to wild-type
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• no evidence of lamellar bodies in type II pneumocytes
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• pups exhibit marked septal thickening
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• some newborns exhibit severe respiratory distress
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• lack of surfactant in bronchial alveolar lavage fluid
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• after remnant kidney surgery, homozygotes exhibit a significantly higher increase in BUN levels relative to similarly-treated wild-type controls
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• serum osteocalcin (BGLAP) levels are significantly higher in sham treated compared to wild-type sham mice at baseline, 14 weeks and remain higher
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• serum TRAP5b (ACP5) concentrations are significantly higher in sham treated compared wild-type sham treated mice at all time points
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• after remnant kidney surgery, homozygotes exhibit a significantly higher increase in serum creatinine levels relative to similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes develop intraluminal thrombi unlike similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes exhibit a significantly higher increase in urinary albumin excretion relative to similarly-treated wild-type controls
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• at 9 weeks of TAC, wild-type hearts exhibit a rightward shift of LV pressure-volume (PV) loops and end-systolic and end-diastolic PV relations reflecting remodeling; in contrast, mutant hearts display a leftward shift with smaller end-diastolic and end-systolic chamber volumes, as well as preserved wall thickness and fractional shortening, indicating preserved or enhanced systolic and diastolic function
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• in fetal atrioventricular endothelial cushions, septum primum and right and left ventricular myocardium
• at E12.5, E15.5 and P1 in the myocardium
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• in fetal atrioventricular endothelial cushions, septum primum and right and left ventricular myocardium
• at E12.5, E15.5 and P1 in the myocardium
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• after remnant kidney surgery, homozygotes exhibit increased mesangial proliferation relative to similarly-treated wild-type controls
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• at 2 months after right subcapsular nephrectomy and surgical resection of the poles of the left kidney to produce a remnant kidney (RK) model, homozygotes exhibit a 4.6-fold increase in peritubular endothelial cell apoptosis relative to similarly-treated wild-type controls
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• in two week old mice based upon TUNEL staining and the presence of Apoptotic nuclei with a dense punctate appearance
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• after remnant kidney surgery, homozygotes exhibit a 36% reduction of proliferating endothelial cells in cortical peritubular capillaries relative to similarly-treated wild-type controls
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• serum osteocalcin (BGLAP) levels are significantly higher in sham compared wit wild-type sham mice at baseline and at 14 wk and remained higher
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• in response to TAC-induced pressure overload, homozygotes (but not wild-type mice) exhibit blunted myocardial ROS generation and blunted nitrotyrosine, and gelatinase zymogen activity with no significant decline in the GSH/GSSH or NADPH/NADP ratio
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• on day 0.5 of estrous cycle, mutant ovaries display a scarce number of ovulation sites and a higher number of anovulatory and luteinized unruptured follicles relative to wild-type controls
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• on day 0.5 of estrous cycle, mutant ovaries exhibit significantly less corpora lutea than wild-type ovaries (9.7 +/- 1.2 versus 14.2 +/- 1.2, respectively)
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• on day 0.5 of estrous cycle, mutant ovaries are significantly smaller than wild-type
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• on day 0.5 of estrous cycle, mutant ovaries display a scarce number of ovulation sites and a higher number of anovulatory and luteinized unruptured follicles relative to wild-type controls
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• on day 0.5 of estrous cycle, mutant ovaries exhibit significantly less corpora lutea than wild-type ovaries (9.7 +/- 1.2 versus 14.2 +/- 1.2, respectively)
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• on day 0.5 of estrous cycle, mutant ovaries are significantly smaller than wild-type
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• female homozygotes display a higher rate of anovulation than wild-type controls (48.3 +/- 7.3% versus 29.7 +/- 6.3, respectively)
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• female homozygotes display a lower ovulation rate than wild-type controls (9.7 +/- 1.2% versus 14.2 +/- 1.2%, respectively)
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• mutant dams show a higher incidence of embryo losses than wild-type dams (62.5% versus 16.7%, respectively)
• the mean rate of embryo losses detected in mutant dams is 49.90.1% versus less than 20% in wild-type dams
• in mutant dams, the highest %s of embryo losses occur between days 8.5 and 10.5 (55.6%) and at day 13.5 postcoitum (44.4% of total losses), whereas in control dams embryo losses occur at days 10.5 and 11.5 postcoitum
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• on days 6.5 and 8.5 of pregnancy, the average number of embryos reaching implantation is lower in mutant mice relative to wild-type mice (4.0 +/- 0.4 versus 7.5 +/- 0.4, respectively)
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• on day 0.5 of estrous cycle, female homozygotes show a significant reduction in the total number of recovered embryos (oocytes/zygotes) relative to wild-type controls (4.0 +/- 1.1 versus 10.4 +/- 1.6, respectively)
• thereafter, a mean of 2.0 +/- 1.0 of these recovered embryos are found to be fertilized, representing a non-fertilization rate of 50.7% versus only 3.3% in control littermates
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• serum concentrations of TRAP5b (ACP5) are significantly higher in sham treated compared to wild-type sham treated mice at all time points
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• fever in response to turpentine injection is enhanced compared to wild-type controls
• unlike in mice null for either Nos1 or Nos2, fever in response to LPS injection is not significantly different from wild-type controls
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• after remnant kidney surgery, homozygotes exhibit increased macrophage infiltration in the glomeruli (15.4-fold) and in the tubulointerstitium (2.7-fold) relative to similarly-treated wild-type controls
• however, a similar increase in glomerular T-cell infiltration (62%) is seen in both RK groups
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• at 2 months after right subcapsular nephrectomy and surgical resection of the poles of the left kidney to produce a remnant kidney (RK) model, homozygotes exhibit a 4.6-fold increase in peritubular endothelial cell apoptosis relative to similarly-treated wild-type controls
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• in two week old mice based upon TUNEL staining and the presence of Apoptotic nuclei with a dense punctate appearance
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• after remnant kidney surgery, homozygotes exhibit a 36% reduction of proliferating endothelial cells in cortical peritubular capillaries relative to similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes exhibit a significantly higher increase in urinary albumin excretion relative to similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes exhibit increased macrophage infiltration in the glomeruli (15.4-fold) and in the tubulointerstitium (2.7-fold) relative to similarly-treated wild-type controls
• however, a similar increase in glomerular T-cell infiltration (62%) is seen in both RK groups
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• in 80% of adult freshly isolated kidneys indentations are observed, indicating zones of parenchymal scarring
• 4% of glomeruli outside scarred area exhibit loss of cellularity and vasculature, a hyalinization like appearance
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• after remnant kidney surgery, homozygotes exhibit a 44% increase in tubulointerstitial injury relative to similarly-treated wild-type controls
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• glomeruli within scarred areas are considerably smaller than wild-type
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• after remnant kidney surgery, homozygotes exhibit a significantly greater endothelial cell loss than similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes exhibit increased mesangial proliferation relative to similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes exhibit increased matrix deposition in some glomeruli unlike similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes develop mesangiolysis unlike similarly-treated wild-type controls
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• within scarred areas
(J:117046)
• after remnant kidney surgery, homozygotes develop significant glomerulosclerosis, unlike similarly-treated wild-type controls
(J:148626)
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• after remnant kidney surgery, homozygotes exhibit a 46% increase in glomerular collagen IV deposition relative to similarly-treated wild-type controls
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• after remnant kidney surgery, homozygotes develop significantly greater glomerular hypertrophy than similarly-treated wild-type controls
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• frequently a large lipid droplet is observed with Bowman's capsule and the adjacent matrix
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• after remnant kidney surgery, homozygotes exhibit more severe sloughing , vacuolization and nuclear exfoliation of tubular epithelial cells relative to similarly-treated wild-type controls
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• thin strands of connective tissue distributed loosely within the interglomerular interstitium
(J:117046)
• after remnant kidney surgery, homozygotes exhibit a 38% increase in collagen III deposition in the tubulointerstitium relative to similarly-treated wild-type controls
(J:148626)
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• within scarred areas
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• the glomeruli often display no clear connection to typical large-diameter proximal tubules
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• after remnant kidney surgery, homozygotes exhibit more severe tubular dilatation than similarly-treated wild-type controls
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• in 2 week old mice, as pyknotic nuclei and vacuolated cytoplasm are observed
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• after remnant kidney surgery, homozygotes exhibit more severe tubular cast formation than similarly-treated wild-type controls
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• degeneration of the glomerular core components is common within the scarred zones
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• after remnant kidney surgery, homozygotes exhibit significantly worse renal function relative to similarly-treated wild-type controls
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• serum osteocalcin (BGLAP) levels are significantly higher in sham compared wit wild-type sham mice at baseline and at 14 wk and remained higher
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• serum concentrations of TRAP5b (ACP5) are significantly higher in sham treated compared to wild-type sham treated mice at all time points
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• exagerated BMD decrease in ovariectomized mice
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• between 10-20 weeks post sham-operation compared to sham-operated wild-type
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• significantly greater cortical thickness in sham operated mice compared to sham operated wild-type mice
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• serum concentrations of TRAP5b (ACP5) are significantly higher in sham treated compared to wild-type sham treated mice at all time points
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| aortic valve disease | DOID:62 | J:103340 | ||
| persistent fetal circulation syndrome | DOID:13042 |
OMIM:265380 |
J:98913 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• moderate albuminuria is observed at 26 weeks of age
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• moderate albuminuria is observed at 26 weeks of age
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• observed by 24 to 28 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of males die by 21 months of age, however female survival is similar to wild-type
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• large increase in heart weight and heart weight to body weight ratio in males at 21 months of age and a smaller increase in females
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• at 21 months of age, males have a large increase and females have a slight increase in heart size
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• both males and females weight less than wild-type at 21 months of age
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• at 21 months of age, males exhibit wall thinning of the heart while females display an increase in wall thickness of the heart
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• females, but not males, exhibit a significant increase in diastolic septal wall thickness and to a lesser degree in the posterior wall
• males exhibit a decrease in interventricular septum thickening at 21 months of age
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• large increase in heart weight and heart weight to body weight ratio in males at 21 months of age and a smaller increase in females
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• at 21 months of age, males have a large increase and females have a slight increase in heart size
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• males at 21 months of age, but not at 5.5 months, exhibit a decrease in left ventricular posterior wall thickness
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• left-ventricular end-systolic chamber dilation (LVESD) is increased about 45% in homozygous males compared to 25% in wild-type males at 21 months of age; no differences seen in females
• left ventricular mass (LVMASS) is increased in both males and females at 21 months of age
• ratio between LVMASS and LV volume is increased in 21 month old males
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• males, but not females, exhibit a marked decrease in ejection fraction and shortening fraction at 21 months of age
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• heart rate is increased in males at 5.5 months of age but not at 21 months of age
• heart rate is normal in females at 5.5 months of age but remains elevated at 21 months of age and does not fall with age as in wild-type
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• mean blood pressure is significantly elevated in both males and females at 5.5 months of age
• at 21 months of age, females, but not males, continue to exhibit increased mean blood pressure
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• females are hypertensive at 7 months of age and maintain the elevated pressure at 21 months of age, however do not exhibit any contractile dysfunction
(J:102136)
• arterial hypertension
(J:103153)
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• elevated at 5.5 months of age in both males and females
• at 21 months of age, females, but not males, continue to exhibit an increased diastolic blood pressure
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• elevated at 5.5 months of age in both males and females
• at 21 months of age, females, but not males, continue to exhibit an increased systolic blood pressure
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• insulin stimulation of muscle blood flow is about 40% smaller than in wild-type
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• plasma nitrite and nitrate concentrations are about 60% lower than in wild-type, indicating a defect of vascular NO production
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• insulin-resistant homozygotes have 50% higher plasma levels of cholesterol
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• insulin-resistant homozygotes have a 2-fold elevation of free fatty acid
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• insulin-resistant homozygotes have a 2-fold elevation of triglycerides
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• glucose infusion rate, glucose turnover rate, and glucose clearance rate are 30-40% lower during a hyperinsulinemic euglycemic clamp study
• basal and insulin-stimulated glucose transport in isolated skeletal muscle is about 40% lower than in wild-type
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• fasting plasma insulin concentration is elevated almost 2-fold
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• fasting hyperinsulinemia and glucose infusion rates during euglycemic clamp studies are 40% lower than in wild-type
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• males, but not females, exhibit a marked decrease in ejection fraction and shortening fraction at 21 months of age
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• insulin stimulation of muscle blood flow is about 40% smaller than in wild-type
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| essential hypertension | DOID:10825 |
OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 |
J:103153 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after injection of platelet-activating factor (PAF), less than 10% mortality occurs within 30 minutes
• pretreatment with wortmannin before PAF treatment confers 100% protection to mutants and wild-type
• in BSA-induced anaphylaxis, all mutants survive compared to fatality in 82% of controls; in OVA model, 92% of control mice die but all mutants survive challenge
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• body weights at 14 weeks of age are approximately 7.5% lower than in wild-type
(J:36559)
• body weight is signifcantly lower than controls at 14 days of age
(J:101254)
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• plasma renin concentrations are nearly twice as high as in wild-type
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• challenge with BSA 2 weeks after sensitization with BSA induces severe hypothermia and mice succumb to systemic shock reaction; mutants show no mortality and only a delayed, mild, transient hypothermia
• similar results are seen with OVA-induced anaphylaxis
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• larger than in controls but only at 14 day
• medial wall area is greater than in controls in the fetus
• muscularity decreases after birth
• muscularity is reduced in the male but still greater than controls
• muscularity in females is like controls by 14 days of age
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• right ventricle/body weight ratio increased in males
• right ventricle/left ventricle+septum ratio increased in males
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• mean right ventricular pressure is elevated in males but not in females
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• 670 beats per min vs. 709 beats per min in wild-type
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• elevated in males but not in females
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• in BSA/BSA model of anaphylaxis, vascular permeability increased significantly in wild-type but very little in mutants; vascular leakage (extravasation) of Evans Blue dye (EB) is 2-fold lower than in wild-type mice
• in OVA/OVA model, no vascular permeability increase occurs in mutants and extravasation is significantly lower than in wild-type
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| N |
• exhibit a similar susceptibility to lipopolysaccharide-induced death as wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes display mild bradycardia relative to wild-type mice
(J:54772)
• notably, chronic treatment of homozygotes with L-NAME induces a significant decrease of heart rate in both wild-type mice and mutant mice
(J:54772)
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• increase in blood pressure by about 18 mmHg
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• homozygotes exhibit modest hypertension relative to wild-type mice
• chronic treatment of homozygotes with NOS inhibitor L-NAME fails to further increase blood pressure; in contrast, chronic L-NAME treatment increases blood pressure in wild-type (C57BL/6J) mice to a level similar to that noted in mutant mice
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• aortic rings isolated from homozygous mutant mice exhibit a significantly enhanced vasoconstriction in response to phenylephrine and a modestly enhanced vasoconstriction in response to serotonin
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• aortic rings isolated from homozygous mutant mice show complete loss of endothelium-dependent vasorelaxation induced by acetylcholine and the calcium ionophore A23187
• in contrast, vasorelaxations to the endothelium-independent vasodilator nitroglycerin are enhanced resulting in a shift of EC50 by ~7-fold relative to wild-type values
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• body weight is approximately 7.5% lower than wild-type at 14 weeks of age
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| N |
• unlike mice null for Nos1 or Nos2, no abnormalities in urine pH or bicarbonate concentrations are detected
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• plasma renin is nearly 2x that of wild-type
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• aortic rings isolated from homozygous mutant mice exhibit a significantly enhanced vasoconstriction in response to phenylephrine and a modestly enhanced vasoconstriction in response to serotonin
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• aortic rings isolated from homozygous mutant mice show complete loss of endothelium-dependent vasorelaxation induced by acetylcholine and the calcium ionophore A23187
• in contrast, vasorelaxations to the endothelium-independent vasodilator nitroglycerin are enhanced resulting in a shift of EC50 by ~7-fold relative to wild-type values
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 38% of mice die by P10 compared with 13% of wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• aortic rings isolated from normotensive heterozygous mutant mice show normal endothelium-dependent vasorelaxation induced by acetylcholine and the calcium ionophore A23187
• however, vasorelaxations to the endothelium-independent vasodilator nitroglycerin are modestly enhanced in heterozygous aortic rings relative to wild-type
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• aortic rings isolated from normotensive heterozygous mutant mice show normal endothelium-dependent vasorelaxation induced by acetylcholine and the calcium ionophore A23187
• however, vasorelaxations to the endothelium-independent vasodilator nitroglycerin are modestly enhanced in heterozygous aortic rings relative to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• microaneurysmal dilations in 20% of males
• sometimes involving coronary arteries
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• plaques larger at 4 months than in Apoetm1Unc homozygotes, by 182% for males and 165% for females
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• plaques in descending aorta in 90% of males as opposed to 20% of Apoetm1Unc males
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• about 20mm higher than in Apoetm1Unc homozygotes
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• 15% of glomeruli with large lipid deposits in foam cells filling the glomeruli
• glomerular injury progresses to dystrophic calcification and glomerular loss
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• 15% lower than in Apoetm1Unc homozygotes
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• 66% higher than controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected double homozygotes are born, no time of lethality provided
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• albumin/creatinine ratio (ACR) is significantly higher than all controls
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• arteriolar hyalinosis
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• glomerular basement membrane is markedly thickened by 16 weeks in comparison to all controls
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• glomerular injury is significantly increased by 24-26 weeks in comparison to all controls
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• marked mesangial expansion is observed at 26 weeks of age
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• marked mesangiolysis is observed at 26 weeks of age
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• focal nodular sclerosis is observed at 26 weeks of age
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• substantial fibronectin accumulation is observed in glomeruli
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• GFR is decreased in comparison to homozygous Nos3tm1Unc and Leprdb controls
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• at 26 weeks, serum creatinine is significantly higher than all controls
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• hyperglycemia is first observed between 6-8 weeks of age, but is not higher than homozygous Leprdb control
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• albumin/creatinine ratio (ACR) is significantly higher than all controls
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• at 26 weeks, body weight is double that of lean and Nos3tm1Unc controls
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• arteriolar hyalinosis
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• hypertension is observed between 24-28 weeks of age, but is not significantly higher than homozygous Nos3tm1Unc controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 2 diabetes mellitus | DOID:9352 |
OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 |
J:135864 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected double homozygotes are born, no time of lethality provided
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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