All Phenotypes Notch1<tm1Con> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch1^tm1Con
targeted mutation 1, Ronald L Conlon
MGI:1857230

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch1^tm1Con/Notch1^tm1Con	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:2175157
hm2	Notch1^tm1Con/Notch1^tm1Con	involves: 129S1/Sv * 129X1/SvJ	MGI:3713582
ht3	Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:7490266
ht4	Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:6236250
cn5	Notch1^tm1Con/Notch1^tm1Grid Tg(Pax2-cre)1Akg/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3713803
cx6	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5523684
cx7	Mib1^em2Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544912
cx8	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544913
cx9	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2	MGI:7640223

Allelic Composition	Notch1^tm1Con/Notch1^tm1Con
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:25248 )

• most mutants are dead at E10 and all die by E11

embryo

abnormal rostral-caudal axis patterning ( J:25248 )

• show a deficit in posterior development at E9

embryonic growth arrest ( J:25248 , J:62882 )

• growth arrest at the 14 somite stage (J:25248)

decreased embryo size ( J:25248 )

• embryos are smaller at E9

kinked neural tube ( J:62882 )

• neural tube kinks are seen extending posterior to the forelimb

notochord degeneration ( J:25248 )

• the notochord degenerates after growth arrest

abnormal somite development ( J:25248 , J:62882 )

• mutants exhibit a lack of coordination in segmentation of the somites, leading to variable somite size and misalignment of the somites across the midline of the embryo (J:25248)

• transition from presomitic mesoderm to the somite is disordered (J:25248)

• the most recently formed somites are not as tightly packed as those of wild-type and the epithelialization sometimes appears incomplete (J:25248)

abnormal left-right axis symmetry of the somites ( J:25248 )

• lack of coordination across the midline in the segmentation of somites, where segmentation is sometimes present on one side but not the other

abnormal somite size ( J:25248 )

• variable somite size

delayed somite formation ( J:25248 )

• mutants exhibit a delay in segmentation of the somites

growth/size/body

decreased embryo size ( J:25248 )

• embryos are smaller at E9

cardiovascular system

distended pericardium ( J:25248 , J:62882 )

• distended pericardia at E9 (J:25248)

cellular

abnormal cell death ( J:25248 )

• an increase in cell death is seen in embryos after they arrest

nervous system

kinked neural tube ( J:62882 )

• neural tube kinks are seen extending posterior to the forelimb

Allelic Composition	Notch1^tm1Con/Notch1^tm1Con
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:119151 )

• the endocardium does not surround the myocardium, which shows irregular thickness

trabecula carnea hypoplasia ( J:119151 )

disorganized myocardium ( J:119151 )

• less-structured myocardium

muscle

abnormal myocardium layer morphology ( J:119151 )

• the endocardium does not surround the myocardium, which shows irregular thickness

trabecula carnea hypoplasia ( J:119151 )

disorganized myocardium ( J:119151 )

• less-structured myocardium

Allelic Composition	Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinas show increased vessel branching at P15 and a higher number of filopodia at the vascular front

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinas show increased vessel branching at P15 and a higher number of filopodia at the vascular front

Allelic Composition	Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:187551 )

N	• mice fed a hypercholesterolemic diet supplemented with vitamin D (HCVD), exhibit normal echocardiography measurements

calcified aortic valve cusp ( J:187551 )

• mice fed the HCVD diet exhibit a moderate level of aortic valve leaflet calcification

thick aortic valve cusps ( J:187551 )

• leaflets are thicker in mice fed control chow and diet does not have an effect on leaflet thickness

aortic valve inflammation ( J:187551 )

• mice exhibit increased aortic valve inflammation when fed the HCVD diet, showing increased macrophage infiltration in the leaflets

immune system

aortic valve inflammation ( J:187551 )

• mice exhibit increased aortic valve inflammation when fed the HCVD diet, showing increased macrophage infiltration in the leaflets

Allelic Composition	Notch1^tm1Con/Notch1^tm1Grid Tg(Pax2-cre)1Akg/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)
Notch1^tm1Grid mutation (0 available); any Notch1 mutation (117 available)
Tg(Pax2-cre)1Akg mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119907 )

• embryos are normal at E12.5, but die at E13.5

renal/urinary system

renal/urinary system phenotype ( J:119907 )

N	• metanephroi appear normal morphologically and histologically when cultured at E12.5

cardiovascular system

abnormal vascular development ( J:119907 )

internal hemorrhage ( J:119907 )

Allelic Composition	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (99 available)
Notch2^tm3.1Rko mutation (0 available); any Notch2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:198632 )

N	• kidneys have functional nephrons in normal numbers; one copy of the Notch1 intracellular domain (N1ICD) expressed from the Notch2 locus is sufficient for nephron formation

Allelic Composition	Mib1^em2Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em2Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal ventricular morphology

abnormal aortic valve morphology ( J:338889 )

• in E16.5 embryos

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

Allelic Composition	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em1Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal valve morphology in E16.5 embryos

Allelic Composition	Eogt^tm1.2Okaj/Eogt^tm1.2Okaj Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eogt^tm1.2Okaj mutation (0 available); any Eogt mutation (44 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single mutant, with even greater vessel branching and number of filopodia at the vascular front

increased vascular permeability ( J:254752 )

• retinas show greater extravascular fibrinogen staining and extravasation of perfused sulfo-NHS-LC-biotin, indicating greater impaired vascular integrity than single Eogt homozygotes

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single mutant, with even greater vessel branching and number of filopodia at the vascular front

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