All Phenotypes Ntf5<tm1Jae> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntf5^tm1Jae/Ntf5^tm1Jae	involves: 129S4/SvJae	MGI:2175182
cx2	Bdnf^tm1Jae/Bdnf^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae	involves: 129S4/SvJae	MGI:3761003
cx3	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae	involves: 129S4/SvJae	MGI:3770686

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 74% and 65%, respectively, compared to in wild-type mice

decreased sensory neuron number ( J:25566 )

• significant loss of all sensory neuron types in the nodose-petrosal, geniculate and L4 dorsal root ganglion in homozygous mice

• no difference in the number of facial motor neurons or superior cervical ganglion neurons is seen compared to controls

• no difference in the number of midbrain dopaminergic neurons is seen compared to controls

small geniculate ganglion ( J:25566 )

• approximately half of the neurons are lost from the geniculate ganglion at E18.5

small petrosal ganglion ( J:25566 )

• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5

small nodose ganglion ( J:25566 )

• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5

small vestibular ganglion ( J:25566 )

• approximately 20% of the neurons are lost from the vestibular ganglion

small L4 dorsal root ganglion ( J:25566 )

• approximately 15% of the neurons are lost from the L4 DRG at two months of age

integument

abnormal hair cycle ( J:53271 )

• retarded catagen progression; follicles are still in early or middle catagen at time points when controls are in late catagen

thick skin ( J:53271 )

• skin thicker than in controls

cellular

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 74% and 65%, respectively, compared to in wild-type mice

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)
Ntf5^tm1Jae mutation (1 available); any Ntf5 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:25566 )

• most homozygous mice die within 48 hours of birth, with only a few surviving up to 10 days of age

growth/size/body

postnatal growth retardation ( J:25566 )

• homozygous mice are the same size as controls at birth, but fail to grow thereafter

nervous system

decreased sensory neuron number ( J:25566 )

• significant loss of all sensory neuron types in the trigeminal, vestibular, nodose-petrosal and geniculate ganglia in homozygous mice

• no statistical difference in the number of facial motor neurons is seen compared to controls

small geniculate ganglion ( J:25566 )

• approximately 95% of the neurons are lost from the geniculate ganglion at E18.5

small petrosal ganglion ( J:25566 )

• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5

small trigeminal ganglion ( J:25566 )

• approximately 30% of the neurons are lost from the trigeminal ganglion at E18.5

small nodose ganglion ( J:25566 )

• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5

small vestibular ganglion ( J:25566 )

• approximately 80% of the neurons are lost from the vestibular ganglion at E18.5

abnormal trigeminal nerve morphology ( J:123022 )

• mice exhibit a 25% loss of trigeminal neurons at birth

behavior/neurological

impaired balance ( J:25566 )

impaired coordination ( J:25566 )

Allelic Composition	Ngfr^tm1Jae/Ngfr^tm1Jae Ntf5^tm1Jae/Ntf5^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfr^tm1Jae mutation (2 available); any Ngfr mutation (33 available)
Ntf5^tm1Jae mutation (1 available); any Ntf5 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice

cellular

decreased neuron apoptosis ( J:123022 )

• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice

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