Analysis Tools|
Allele Symbol Allele Name Allele ID |
Prkcgtm1Stl targeted mutation 1, Susumu Tonegawa MGI:1857237 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• developed tolerance to sedative-hypnotic effects of chronic (10 day) ethanol diet
• developed chronic hypothermia tolerance after 10 day ethanol diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal spatial learning in Morris water maze tasks, relative to controls of same genetic background
• normal contextual conditioning relative to controls of same genetic background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal cued conditioning
(J:16391)
• normal behavior
(J:16392)
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• moderate deficit compared to controls
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• mild deficit in random platform Morris water maze task, deficit overcome with intensive training, however
• normal spatial learning in both the visible- and hidden-platform Morris water mazes
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| N |
• normal paired-pulse facilitation
• normal long term depression
• normal brain anatomy
• normal baseline synaptic transmission in hippocampal CA1 pyrimidal cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ingested more ethanol than controls, but no greater consumption of liquid volume
• while both males and females consumed more ethanol than controls, females consumed more than males
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• lack of tolerance to sedative-hypnotic effects of chronic (10 day) ethanol diet
• developed chronic hypothermia tolerance after 10 day ethanol diet
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• in elevated plus-maze, black/white box, and mirrored chamber
• baseline locomotor activity is similar to controls
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• greater behavioral impulsivity in appetitive-signaled nosepoke test
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| N |
• saccharin preference similar to controls
• nicotine consumption similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• lack of tolerance to sedative-hypnotic effects of chronic (10 day) ethanol diet
• failed to develop chronic hypothermia tolerance after 10 day ethanol diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced sensitivity to ethanol on loss of righting reflex and hypothermia
• no such alterations in sensitivity to flunitrazepam or pentobarbital
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• attenuated response during the second, prolonged phase of nociceptive pain after formalin-injection into paw
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• failed to develop neuropathic pain (induced by thermal or mechanical means) after partial sciatic nerve section
• reduced neurochemical changes in the spinal cord after nerve injury
• normal response to acute pain (thermal or mechanical) stimuli in the absence of nerve injury
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• reduced plasma extravasation in response to intradermal capsaicin injection in the paw
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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