All Phenotypes Rab3a<tm1Sud> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rab3a^tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:1857240

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab3a^tm1Sud/Rab3a^tm1Sud	involves: 129	MGI:3625934
hm2	Rab3a^tm1Sud/Rab3a^tm1Sud	involves: 129 * C57BL/6J	MGI:2388814
ht3	Rab3a^tm1Sud/Rab3a⁺	involves: 129 * C57BL/6J	MGI:2388813
ht4	Rab3a^tm1Sud/Rab3a^Ebd	involves: 129 * C57BL/6J	MGI:2388815
cx5	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625947
cx6	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b⁺ Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625948
cx7	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c⁺ Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625949
cx8	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d⁺	involves: 129 * 129P2/OlaHsd	MGI:3625950
cx9	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625951
cx10	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud	involves: 129 * 129P2/OlaHsd	MGI:3625955
cx11	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625965
cx12	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud	involves: 129 * 129P2/OlaHsd	MGI:3625933
cx13	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud	involves: 129 * 129P2/OlaHsd	MGI:3625940
cx14	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625943
cx15	Rab3a^tm1Sud/Rab3a⁺ Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625945

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased synaptic depression ( J:64297 )

• significant increase in synaptic depression of transmission after short trains of repetitive stimuli (15-30 stimuli at 14 Hz) in sections of the hippocampus

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

shortened circadian behavior period ( J:79562 )

• 23.39 +/- 0.09 hours for homozygotes on a mixed B6;129 genetic background compared to 23.71 +/-0.03 hours of control littermates

Allelic Composition	Rab3a^tm1Sud/Rab3a⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

shortened circadian behavior period ( J:79562 )

• 23.45 +/- 0.04 hours for heterozygotes on a mixed B6;129 genetic background compared to 23.71 +/-0.03 hours of control littermates

Allelic Composition	Rab3a^tm1Sud/Rab3a^Ebd
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^Ebd mutation (0 available); any Rab3a mutation (15 available)
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

shortened circadian behavior period ( J:79562 )

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological

abnormal behavior ( J:105478 )

• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)

respiratory system

respiratory distress ( J:105478 )

• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b⁺ Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• 50% of triple Rab3 knockouts with one copy of Rab3c survive

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age

respiratory system

respiratory distress ( J:105478 )

• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c⁺ Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d⁺
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:105478 )

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:105478 )

• quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress

homeostasis/metabolism

cyanosis ( J:105478 )

• newborn mice are cyanotic

nervous system

abnormal CNS synaptic transmission ( J:104983 )

• synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control

abnormal excitatory postsynaptic currents ( J:104983 , J:105478 )

• repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls (J:104983)

• EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles (J:104983)

• EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts (J:105478)

decreased neurotransmitter release ( J:105478 )

• in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type

enhanced paired-pulse facilitation ( J:104983 )

• neurons show strong paired-pulse facilitation

respiratory system

abnormal breathing pattern ( J:105478 )

• newborn mice exhibit shallow and irregular breathing patterns

respiratory distress ( J:105478 )

• newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• only 50% of triple Rab3 knockouts with wild-type Rab3d survive

growth/size/body

decreased body weight ( J:105478 )

• male triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological

abnormal behavior ( J:105478 )

• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• less than 100% of triple knockouts survive

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age

behavior/neurological

abnormal behavior ( J:105478 )

• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b^tm1Sud
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:105478 )

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal maternal nurturing ( J:105478 )

• double knockouts do not take care of offspring well

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:105478 )

Allelic Composition	Rab3a^tm1Sud/Rab3a⁺ Rab3b^tm1Sud/Rab3b^tm1Sud Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (15 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (21 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:105478 )

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