All Phenotypes Ccl3<tm1Unc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccl3^tm1Unc
targeted mutation 1, University of North Carolina
MGI:1857243

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl3^tm1Unc/Ccl3^tm1Unc	B6.129P2-Ccl3^tm1Unc/J	MGI:3524873
hm2	Ccl3^tm1Unc/Ccl3^tm1Unc	involves: 129P2/OlaHsd	MGI:2660695
hm3	Ccl3^tm1Unc/Ccl3^tm1Unc	involves: 129P2/OlaHsd * C57BL/6	MGI:4418575
cx4	Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3579804
cx5	Ccl3^tm1Unc/Ccl3⁺ Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3579805

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc
Genetic Background	B6.129P2-Ccl3^tm1Unc/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

alcohol aversion ( J:102583 )

decreased alcohol consumption ( J:102583 )

abnormal conditioned taste aversion behavior ( J:102583 )

• male mice consume more saccharin in an ethanol-induced conditioned taste aversion test compared with similarly treated wild-type mice

• mice exhibit a stronger response to ethanol in an ethanol-induced conditioned taste aversion test compared with similarly treated wild-type mice

• however, saccharin consumption in female mice is normal

increased fluid intake ( J:102583 )

• male mice exhibit increased drinking of an ethanol or quinine solution compared with similarly treated wild-type mice

impaired righting response ( J:102583 )

• mice exhibit longer duration of ethanol-induced loss of righting response compared with similarly treated wild-type mice

immune system

decreased neutrophil cell number ( J:94599 )

• 13-28% decrease in the number of infiltrating neutrophils in the skin at 4 and 8 hours after immune complex challenge compared to wild-type

decreased susceptibility to type III hypersensitivity reaction ( J:94599 )

• 20% reduction in edema, but no difference in hemorrhage, when cutaneous reverse passive Arthus reaction was induced compared to wild-type

hematopoietic system

decreased neutrophil cell number ( J:94599 )

• 13-28% decrease in the number of infiltrating neutrophils in the skin at 4 and 8 hours after immune complex challenge compared to wild-type

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

cecum inflammation ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

decreased susceptibility to bacterial infection ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

abnormal susceptibility to Orthomyxoviridae infection ( J:107677 )

• influenza viral titers are higher in mutants at day 3, 6 and 7 post infection compared to wild-type, however by day 21 post infection, no virus is detected, indicating a delay in T cell-dependent viral clearance

decreased susceptibility to Orthomyxoviridae infection ( J:107677 )

• reduced pneumonitis after infection with influenza virus

decreased susceptibility to Picornaviridae infection ( J:28704 )

• resistance to Coxsackie virus-induced myocarditis

digestive/alimentary system

cecum inflammation ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:70862 )

N	• mice exhibit normal wound healing

nervous system

decreased microglial cell activation ( J:153059 )

• significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40

abnormal astrocyte physiology ( J:153059 )

• significant reduction in activated astrocytes in the hippocampus 6 hours after injection of beta amyloid 1-40

behavior/neurological

abnormal spatial learning ( J:153059 )

• improved learning performance in a Morris water maze after injection of beta amyloid 1-40 relative to controls

abnormal long-term spatial reference memory ( J:153059 )

• in a Morris water maze

immune system

decreased microglial cell activation ( J:153059 )

• significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40

hematopoietic system

decreased microglial cell activation ( J:153059 )

• significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (17 available)
Hexb^tm1Rlp mutation (1 available); any Hexb mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hexb^tm1Rlp/Hexb^tm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice

mortality/aging

premature death ( J:90687 )

• life span of approximately 156 days (maximum 175 days)

behavior/neurological

abnormal motor coordination/balance ( J:90687 )

• improved performance on a rotarod compared to mice homozygous for the Hexb allele alone

abnormal righting response ( J:90687 )

• improved relative to mice homozygous for the Hexb allele alone

growth/size/body

growth/size/body region phenotype ( J:90687 )

N	• maintained body weight through 19 weeks of age

immune system

abnormal tumor necrosis factor level ( J:90687 )

• 87% reduction of TNF alpha in the spinal cord relative to levels seen in mice homozygous only for Hexb^tm1Rlb

CNS inflammation ( J:90687 )

• fewer cells infiltrating the CNS of 4 month old mice

cellular

cellular phenotype ( J:90687 )

N	• near absence of apoptosis in the central nervous system

nervous system

CNS inflammation ( J:90687 )

• fewer cells infiltrating the CNS of 4 month old mice

homeostasis/metabolism

abnormal tumor necrosis factor level ( J:90687 )

• 87% reduction of TNF alpha in the spinal cord relative to levels seen in mice homozygous only for Hexb^tm1Rlb

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sandhoff disease		DOID:3323	OMIM:268800	J:90687

Allelic Composition	Ccl3^tm1Unc/Ccl3⁺ Hexb^tm1Rlp/Hexb^tm1Rlp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:90687 )

• life span of approximately 138 day

behavior/neurological

abnormal motor coordination/balance ( J:90687 )

• improved performance on a rotarod compared to mice homozygous for the Hexb allele alone

abnormal righting response ( J:90687 )

• improved relative to mice homozygous for the Hexb allele alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sandhoff disease		DOID:3323	OMIM:268800	J:90687

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24