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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Selptm1Bay
targeted mutation 1, Baylor College of Medicine
MGI:1857244
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Selptm1Bay/Selptm1Bay B6.129S7-Selptm1Bay MGI:3835011
hm2
 		Selptm1Bay/Selptm1Bay B6.129S7-Selptm1Bay/J MGI:3699811
hm3
 		Selptm1Bay/Selptm1Bay D1.129S7(B6J)-Selptm1Bay MGI:3606585
hm4
 		Selptm1Bay/Selptm1Bay either: B6.129S7-Selptm1Bay or (involves: 129S7/SvEvBrd * C57BL/6) MGI:3766606
hm5
 		Selptm1Bay/Selptm1Bay involves: 129S7/SvEvBrd * C57BL/6 MGI:3766951
hm6
 		Selptm1Bay/Selptm1Bay involves: 129S7/SvEvBrd * C57BL/6J MGI:3606578
cx7
 		Icam1tm1Bay/Icam1tm1Bay
Selptm1Bay/Selptm1Bay 		B6.129S7-Icam1tm1Bay Selptm1Bay/J MGI:3767011
cx8
 		Icam1tm1Bay/Icam1tm1Bay
Selptm1Bay/Selptm1Bay 		either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6) MGI:3766607
cx9
 		Icam1tm1Bay/Icam1tm1Bay
Seletm2Alb/Seletm2Alb
Selptm1Bay/Selptm1Bay 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3766947
cx10
 		Seletm2Alb/Seletm2Alb
Selptm1Bay/Selptm1Bay 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3766950
cx11
 		Seletm2Alb/Seletm2Alb
Selltm2Alb/Selltm2Alb
Selptm1Bay/Selptm1Bay 		involves: 129S7/SvEvBrd * C57BL/6 MGI:2656301
cx12
 		Seletm2Alb/Seletm2Alb
Selptm1Bay/Selptm1Bay 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3606634
cx13
 		Icam1tm1Bay/Icam1tm1Bay
Selptm1Bay/Selptm1Bay 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3606608
cx14
 		Faslpr/Faslpr
Selptm1Bay/Selptm1Bay 		MRL.Cg-Selptm1Bay Faslpr MGI:3799723


Genotype
MGI:3835011
hm1
Allelic
Composition		 Selptm1Bay/Selptm1Bay
Genetic
Background		 B6.129S7-Selptm1Bay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mast cell number ( J:121083 )
• during the chronic phase of antigen exposure
decreased susceptibility to type IV hypersensitivity reaction ( J:121083 )
• chronic inflammation in response to oxazolone exposure is inhibited compared to in similarly treated wild-type mice
• however, acute inflammation in response to oxazolone exposure is normal

hematopoietic system
decreased mast cell number ( J:121083 )
• during the chronic phase of antigen exposure




Genotype
MGI:3699811
hm2
Allelic
Composition		 Selptm1Bay/Selptm1Bay
Genetic
Background		 B6.129S7-Selptm1Bay/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:113536 )
• T lymphocyte migration and accumulation into cutaneous inflammatory regions induced by a combination of IFN-gamma and TNF-alpha is inhibited by about 25%, however IFN-gamma, TNF-alpha, and ConA, has no effect on T cell infiltration

hematopoietic system
abnormal T cell physiology ( J:113536 )
• T lymphocyte migration and accumulation into cutaneous inflammatory regions induced by a combination of IFN-gamma and TNF-alpha is inhibited by about 25%, however IFN-gamma, TNF-alpha, and ConA, has no effect on T cell infiltration




Genotype
MGI:3606585
hm3
Allelic
Composition		 Selptm1Bay/Selptm1Bay
Genetic
Background		 D1.129S7(B6J)-Selptm1Bay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased susceptibility to induced arthritis ( J:57086 )
• accelerated incidence of induced arthritis, 23% compared to 2% of DBA/1 mice by 28 days
• increase in number of affected paws
• consistently higher arthritis severity scores as determined by inflammation, paw/digit distortion and ankylosis
• onset of arthritis occurs as early as day 14 with a median onset of 34 days

immune system
increased IgG level ( J:57086 )
• increased levels of serum IgG anti-type II collagen antibody measured in collagen immunized mice as compared to immunized DBA/1 mice
abnormal cytokine secretion ( J:57086 )
• increased levels of IL10 and IL5 measured in stimulated splenocytes
• decreased levels of IL2 and IL4 measured in stimulated splenocytes
increased susceptibility to induced arthritis ( J:57086 )
• accelerated incidence of induced arthritis, 23% compared to 2% of DBA/1 mice by 28 days
• increase in number of affected paws
• consistently higher arthritis severity scores as determined by inflammation, paw/digit distortion and ankylosis
• onset of arthritis occurs as early as day 14 with a median onset of 34 days

hematopoietic system
increased IgG level ( J:57086 )
• increased levels of serum IgG anti-type II collagen antibody measured in collagen immunized mice as compared to immunized DBA/1 mice




Genotype
MGI:3766606
hm4
Allelic
Composition		 Selptm1Bay/Selptm1Bay
Genetic
Background		 either: B6.129S7-Selptm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal leukocyte tethering or rolling ( J:31374 )
• after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)
• leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)
• treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second
increased leukocyte cell number ( J:31374 )
• systemic leukocyte counts are ~9800/ul (~61% neutrophils, ~37% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)

immune system
abnormal leukocyte tethering or rolling ( J:31374 )
• after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)
• leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)
• treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second
increased leukocyte cell number ( J:31374 )
• systemic leukocyte counts are ~9800/ul (~61% neutrophils, ~37% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)

cellular
abnormal leukocyte tethering or rolling ( J:31374 )
• after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)
• leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)
• treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second




Genotype
MGI:3766951
hm5
Allelic
Composition		 Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased neutrophil cell number ( J:112286 )
• circulating neutrophils are increased in mutants and this increases with age of mice

immune system
increased neutrophil cell number ( J:112286 )
• circulating neutrophils are increased in mutants and this increases with age of mice




Genotype
MGI:3606578
hm6
Allelic
Composition		 Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:24239 )
• Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours
increased leukocyte cell number ( J:101979 )
• elevated peripheral leukocyte count in contrast to controls following infection with S. pneumoniae
increased neutrophil cell number ( J:24239 , J:101979 )
• 2-3 fold increase in numbers of circulating neutrophils (J:24239)
• mild neutrophilia in contrast to controls following infection with S. pneumoniae (J:101979)
abnormal spleen morphology ( J:101979 )
• increase in splenic thrombosis and necrosis in contrast to controls following infection with S. pneumoniae
eye inflammation ( J:101979 )
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
increased susceptibility to bacterial infection ( J:101979 )
• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae
• survival rate was 19% in contrast to a 57% rate for wild-type mice
• decreased ability to clear bacteremia among survivors

behavior/neurological
abnormal pilomotor reflex ( J:101979 )
• observed following infection with S. pneumoniae
tremors ( J:101979 )
• observed following infection with S. pneumoniae
head tilt ( J:101979 )
• observed following infection with S. pneumoniae
decreased locomotor activity ( J:101979 )
• observed following infection with S. pneumoniae
spinning ( J:101979 )
• observed following infection with S. pneumoniae

liver/biliary system
hepatic necrosis ( J:101979 )
• higher incidence in contrast to controls following infection with S. pneumoniae

growth/size/body
weight loss ( J:101979 )
• observed 48 hours post-infection with S. pneumoniae

vision/eye
eye inflammation ( J:101979 )
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

hematopoietic system
abnormal leukocyte migration ( J:24239 )
• Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours
increased leukocyte cell number ( J:101979 )
• elevated peripheral leukocyte count in contrast to controls following infection with S. pneumoniae
increased neutrophil cell number ( J:24239 , J:101979 )
• 2-3 fold increase in numbers of circulating neutrophils (J:24239)
• mild neutrophilia in contrast to controls following infection with S. pneumoniae (J:101979)
abnormal spleen morphology ( J:101979 )
• increase in splenic thrombosis and necrosis in contrast to controls following infection with S. pneumoniae

cellular
abnormal leukocyte migration ( J:24239 )
• Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours




Genotype
MGI:3767011
cx7
Allelic
Composition		 Icam1tm1Bay/Icam1tm1Bay
Selptm1Bay/Selptm1Bay
Genetic
Background		 B6.129S7-Icam1tm1Bay Selptm1Bay/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Bay mutation (2 available); any Icam1 mutation (25 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:119906 )
N
• no significant differences are detected in motor function (assessed at 1-5 days after CCI) or cognitive function (assessed at 14-20 days after injury) between mutants and wild-type mice
• no significant differences are seen in contusion volume of the injured hemisphere or in volume of uninjured or injured hemisphere between wild-type and mutants 21 days after CCI

immune system
immune system phenotype ( J:119906 )
N
• no difference in neutrophil accumulation at injury site at 24 hours after CCI is detected between mutant and wild-type mice

homeostasis/metabolism
edema ( J:119906 )
• brain edema at 24 hours after controlled cortical impact (CCI) is decreased in mutants compared to controls; brain water content ratio of injured and uninjured hemispheres) is lower (1.90) than in controls (3.16)




Genotype
MGI:3766607
cx8
Allelic
Composition		 Icam1tm1Bay/Icam1tm1Bay
Selptm1Bay/Selptm1Bay
Genetic
Background		 either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Bay mutation (2 available); any Icam1 mutation (25 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired leukocyte tethering or rolling ( J:31374 )
• double mutants show no spontaneous rolling leukocyte activity
• treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants

cellular
impaired leukocyte tethering or rolling ( J:31374 )
• double mutants show no spontaneous rolling leukocyte activity
• treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants

hematopoietic system
impaired leukocyte tethering or rolling ( J:31374 )
• double mutants show no spontaneous rolling leukocyte activity
• treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants




Genotype
MGI:3766947
cx9
Allelic
Composition		 Icam1tm1Bay/Icam1tm1Bay
Seletm2Alb/Seletm2Alb
Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Bay mutation (2 available); any Icam1 mutation (25 available)
Seletm2Alb mutation (0 available); any Sele mutation (51 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:112286 )
• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation
increased neutrophil cell number ( J:112286 )
• circulating neutrophils are increased in mice with acute croton oil dermatitis
decreased acute inflammation ( J:112286 )
• in response to croton oil application to the ear in young mice (7-14 weeks), inflammation is significantly reduced relative to controls

hematopoietic system
impaired neutrophil chemotaxis ( J:112286 )
• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation
increased neutrophil cell number ( J:112286 )
• circulating neutrophils are increased in mice with acute croton oil dermatitis

homeostasis/metabolism
skin edema ( J:112286 )
• dermal edema is decreased by 41% within 6 hours of croton oil irritation in young mice (7-14 weeks), and partial suppression of edema in older (23-35 weeks) mice

integument
integument phenotype ( J:112286 )
N
• triply deficient mice do not develop spontaneous skin lesions up to 55 weeks of age
skin edema ( J:112286 )
• dermal edema is decreased by 41% within 6 hours of croton oil irritation in young mice (7-14 weeks), and partial suppression of edema in older (23-35 weeks) mice

cellular
impaired neutrophil chemotaxis ( J:112286 )
• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation




Genotype
MGI:3766950
cx10
Allelic
Composition		 Seletm2Alb/Seletm2Alb
Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm2Alb mutation (0 available); any Sele mutation (51 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired leukocyte tethering or rolling ( J:70682 )
• rolling is severely compromised
• rolling flux and rolling fraction are reduced relative to wild-type
increased leukocyte cell number ( J:70682 )
• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type
increased neutrophil cell number ( J:70682 , J:112286 )
• circulating neutrophils are increased in mutants and this increases with age of mice (J:112286)
• circulating neutrophils are increased to a greater extent in older mutants showing spontaneous lesions than in those without spontaneous lesions (J:112286)
abnormal spleen B cell follicle morphology ( J:70682 )
• lymphoid follicles forming the white pulp are effaced and infrequently observed due to expansion of the red pulp by extramedullary hematopoiesis
abnormal neutrophil physiology ( J:112286 )
• migration is defective in young mice (7-14 weeks) in acute croton oil dermatitis model
• in older mutants (23-35 weeks), neutrophil emigration during irritant dermatitis shows no compromise compared to wild-type
• in young mice (8 weeks) with croton oil-induced lesions on their backs 15 days before acute croton oil-induced dermatitis on the ear, a 5-fold greater emigration of neutrophils to the ear irritation is observed compared to mutants without experimental lesions on their backs, while circulating neutrophil numbers are similar for both groups
abnormal lymph node secondary follicle morphology ( J:70682 )
• structures aren't recognized in mutant cervical lymph nodes
abnormal lymph node germinal center morphology ( J:70682 )
• structures aren't recognized in mutant cervical lymph nodes
enlarged lymph nodes ( J:70682 )
• both old and young mice show severe cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is more severe than in Sele/Selp/Sell-triple null mice
abnormal cytokine secretion ( J:70682 )
• GM-CSF levels are elevated 6-7-fold above levels in wild-type or Sell-null mice
decreased acute inflammation ( J:112286 )
• standardized volume fraction of emigrated neutrophils in dermis of irritated ears is 0.017 +/- 0.006, compared to 0.317 in irritated ears of wild-type mice

hematopoietic system
impaired leukocyte tethering or rolling ( J:70682 )
• rolling is severely compromised
• rolling flux and rolling fraction are reduced relative to wild-type
extramedullary hematopoiesis ( J:70682 )
• mice show massive extramedullary hematopoiesis with identifiable myeloid and megakaryocytic lineages, and lesser erythroid component
increased leukocyte cell number ( J:70682 )
• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type
increased neutrophil cell number ( J:70682 , J:112286 )
• circulating neutrophils are increased in mutants and this increases with age of mice (J:112286)
• circulating neutrophils are increased to a greater extent in older mutants showing spontaneous lesions than in those without spontaneous lesions (J:112286)
abnormal spleen B cell follicle morphology ( J:70682 )
• lymphoid follicles forming the white pulp are effaced and infrequently observed due to expansion of the red pulp by extramedullary hematopoiesis
abnormal neutrophil physiology ( J:112286 )
• migration is defective in young mice (7-14 weeks) in acute croton oil dermatitis model
• in older mutants (23-35 weeks), neutrophil emigration during irritant dermatitis shows no compromise compared to wild-type
• in young mice (8 weeks) with croton oil-induced lesions on their backs 15 days before acute croton oil-induced dermatitis on the ear, a 5-fold greater emigration of neutrophils to the ear irritation is observed compared to mutants without experimental lesions on their backs, while circulating neutrophil numbers are similar for both groups

cardiovascular system
abnormal lung vasculature morphology ( J:70682 )
• in mutants, alveolocapillary walls are engorged with leukocytes; these leukocytes are confined to small vascular spaces and do not infiltrate the interstitial supporting tissue or alveolar and airway spaces

respiratory system
abnormal lung morphology ( J:70682 )
• lung tissue displays decreasing cellularity within alveolocapillary walls with severely affected interstitial areas
abnormal lung vasculature morphology ( J:70682 )
• in mutants, alveolocapillary walls are engorged with leukocytes; these leukocytes are confined to small vascular spaces and do not infiltrate the interstitial supporting tissue or alveolar and airway spaces

integument
spontaneous skin ulceration ( J:70682 , J:112286 )
• mice develop mucocutaneous infections or ulcerative dermatitis (J:70682)
• at 15 months, mice show large areas of ulceration on the neck (J:70682)
• mice develop spontaneous skin lesions characterized by polymorphonuclear leukocytes (J:112286)

cellular
impaired leukocyte tethering or rolling ( J:70682 )
• rolling is severely compromised
• rolling flux and rolling fraction are reduced relative to wild-type




Genotype
MGI:2656301
cx11
Allelic
Composition		 Seletm2Alb/Seletm2Alb
Selltm2Alb/Selltm2Alb
Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm2Alb mutation (0 available); any Sele mutation (51 available)
Selltm2Alb mutation (0 available); any Sell mutation (42 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:70682 )
N
• GM-CSF levels are comparable to levels in wild-type or Sell-null mutants; elevation observed in Sele/Selp double null mice is absent
abnormal cellular extravasation ( J:70682 )
• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
impaired leukocyte tethering or rolling ( J:70682 )
• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
increased leukocyte cell number ( J:70682 )
• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type, but are ~half the value found in Sele/Selp double mutants
increased neutrophil cell number ( J:70682 , J:106550 )
• in liver parenchyma and sinusoids, neutrophil numbers are ~2-fold higher in mutants after Gal/ET treatment; numbers of neutrophils in liver tissue are significantly elevated 4 hours prior to Gal/ET treatment, compared to controls (J:106550)
• more neutrophils accumulate in the hepatic vascular beds (sinusoids and venules) after Gal/ET treatment in mutants than in wild-type controls (J:106550)
abnormal spleen morphology ( J:70682 )
• moderate disruption of splenic architecture is observed
abnormal spleen B cell follicle morphology ( J:70682 )
• lymphoid follicles of the white pulp are identified occasionally and have irregular shapes and sizes
enlarged lymph nodes ( J:70682 )
• both old and young mice show severe cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is more severe than in Sele/Selp/Sell-triple null mice
abnormal cervical lymph node morphology ( J:70682 )
• both old and young mice show marked cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is less severe than in Sele/Sell-double null mice
lung inflammation ( J:70682 )
• both old and younger mice show bronchial lymphoid aggregates

hematopoietic system
abnormal cellular extravasation ( J:70682 )
• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
impaired leukocyte tethering or rolling ( J:70682 )
• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
extramedullary hematopoiesis ( J:70682 )
• mice show moderate extramedullary hematopoiesis in sinusoid of red pulp
increased leukocyte cell number ( J:70682 )
• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type, but are ~half the value found in Sele/Selp double mutants
increased neutrophil cell number ( J:70682 , J:106550 )
• in liver parenchyma and sinusoids, neutrophil numbers are ~2-fold higher in mutants after Gal/ET treatment; numbers of neutrophils in liver tissue are significantly elevated 4 hours prior to Gal/ET treatment, compared to controls (J:106550)
• more neutrophils accumulate in the hepatic vascular beds (sinusoids and venules) after Gal/ET treatment in mutants than in wild-type controls (J:106550)
abnormal spleen morphology ( J:70682 )
• moderate disruption of splenic architecture is observed
abnormal spleen B cell follicle morphology ( J:70682 )
• lymphoid follicles of the white pulp are identified occasionally and have irregular shapes and sizes

respiratory system
lung inflammation ( J:70682 )
• both old and younger mice show bronchial lymphoid aggregates
abnormal lung morphology ( J:70682 )
• lung tissue displays decreasing cellularity within alveolocapillary walls, but this is less severe than in Sele/Selp double-nulls
abnormal lung vasculature morphology ( J:70682 )
• only a small increase in leukocytes in alveolocapillary walls are observed and occasional small bronchial lymphoid aggregates are found

cardiovascular system
abnormal lung vasculature morphology ( J:70682 )
• only a small increase in leukocytes in alveolocapillary walls are observed and occasional small bronchial lymphoid aggregates are found

liver/biliary system
hepatic necrosis ( J:106550 )
• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, area on necrosis is attenuated 68% compared to treated controls
abnormal liver physiology ( J:106550 )
• mutants show decreased liver injury relative to treated controls at 7 hours after treatment with Gal/ET

homeostasis/metabolism
decreased circulating alanine transaminase level ( J:106550 )
• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, plasma ALT levels are reduced by 65% compared to treated controls

integument
integument phenotype ( J:70682 )
N
• mice do not show skin ulcerations as seen in double Sele/Selp mutants

cellular
abnormal cellular extravasation ( J:70682 )
• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
impaired leukocyte tethering or rolling ( J:70682 )
• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice




Genotype
MGI:3606634
cx12
Allelic
Composition		 Seletm2Alb/Seletm2Alb
Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm2Alb mutation (0 available); any Sele mutation (51 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte cell number ( J:101979 )
• elevated peripheral leukocyte count (3 fold) relative to controls prior to and following infection
• decreased peritoneal WBC count relative to peripheral WBC count following infection
increased neutrophil cell number ( J:101979 )
• neutrophilia in contrast to controls following infection with S. pneumoniae
• decreased number of neutrophils in peritoneal fluid relative to peripheral absolute neutrophil counts following infection
eye inflammation ( J:101979 )
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
increased susceptibility to bacterial infection ( J:101979 )
• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae
• decreased survival rate after post-infection day 5
• decreased ability to clear bacteremia among survivors

behavior/neurological
abnormal pilomotor reflex ( J:101979 )
• observed following infection with S. pneumoniae
tremors ( J:101979 )
• observed following infection with S. pneumoniae
head tilt ( J:101979 )
• observed following infection with S. pneumoniae
decreased locomotor activity ( J:101979 )
• observed following infection with S. pneumoniae
spinning ( J:101979 )
• observed following infection with S. pneumoniae

growth/size/body
weight loss ( J:101979 )
• 48 hours post-infection with S. pneumoniae

vision/eye
eye inflammation ( J:101979 )
• panophthalmitis observed in 8% of mice following infection with S. pneumoniae

hematopoietic system
abnormal leukocyte cell number ( J:101979 )
• elevated peripheral leukocyte count (3 fold) relative to controls prior to and following infection
• decreased peritoneal WBC count relative to peripheral WBC count following infection
increased neutrophil cell number ( J:101979 )
• neutrophilia in contrast to controls following infection with S. pneumoniae
• decreased number of neutrophils in peritoneal fluid relative to peripheral absolute neutrophil counts following infection




Genotype
MGI:3606608
cx13
Allelic
Composition		 Icam1tm1Bay/Icam1tm1Bay
Selptm1Bay/Selptm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Bay mutation (2 available); any Icam1 mutation (25 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:24239 )
• Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
• Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space
increased neutrophil cell number ( J:24239 )
• 4-5 fold increase in numbers of circulating neutrophils

hematopoietic system
abnormal leukocyte migration ( J:24239 )
• Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
• Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space
increased neutrophil cell number ( J:24239 )
• 4-5 fold increase in numbers of circulating neutrophils

cellular
abnormal leukocyte migration ( J:24239 )
• Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
• Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space




Genotype
MGI:3799723
cx14
Allelic
Composition		 Faslpr/Faslpr
Selptm1Bay/Selptm1Bay
Genetic
Background		 MRL.Cg-Selptm1Bay Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Selptm1Bay mutation (3 available); any Selp mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:127199 )
• overall survival is reduced compared to Faslpr homozygotes (median survival is 20 weeks vs 26 weeks for Fas mutants); renal lesions are severe at time of death

immune system
abnormal leukocyte adhesion ( J:126009 )
• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
impaired leukocyte tethering or rolling ( J:126009 )
• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
increased neutrophil cell number ( J:127199 )
• severe neutrophil accumulation at 20 weeks is observed in kidneys
abnormal chemokine secretion ( J:127199 )
• in kidney and cultured primary renal endothelial cells, levels of CCL2 are elevated compared to Faslpr controls at 20 weeks; expression levels are increased further upon LPS treatment of cells
glomerulonephritis ( J:127199 )
• at 20 weeks of age, kidneys display higher lesion scores than controls
dermatitis ( J:127199 )
• double mutants show more rapid onset of cutaneous inflammation than Faslpr homozygotes

hematopoietic system
abnormal leukocyte adhesion ( J:126009 )
• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
impaired leukocyte tethering or rolling ( J:126009 )
• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
increased neutrophil cell number ( J:127199 )
• severe neutrophil accumulation at 20 weeks is observed in kidneys

renal/urinary system
abnormal renal glomerular capsule morphology ( J:127199 )
• at 20 weeks of age, severely affected glomeruli display capsular fibrosis and proliferation of the lining of Bowman's capsule
fused podocyte foot processes ( J:127199 )
• at 20 weeks of age, foot processes are fused
podocyte foot process effacement ( J:127199 )
• at 20 weeks of age, foot processes are diffusely effaced
abnormal renal glomerulus morphology ( J:127199 )
• lesions at 20 weeks are characterized by neutrophil infiltration of the glomerular tuft, proliferation of mesangial and endothelial cells, mild multifocal tubular atrophy, and interstitial mixed inflammatory cell accumulation
• more severely affected glomeruli have necrosis of large areas of the tuft, fibrin deposition, proliferation of lining of Bowman's capsule with fusion of the tuft (synechia), capsular fibrosis, and pericapsular lymphocyte accumulation
• subepithelial and subendothelial electron-dense deposits are detected
abnormal glomerular capillary endothelium morphology ( J:127199 )
• at 20 weeks of age, proliferation of endothelial cells is observed
increased mesangial cell number ( J:127199 )
• at 20 weeks of age, cellularity of mesangium is moderately increased
glomerulonephritis ( J:127199 )
• at 20 weeks of age, kidneys display higher lesion scores than controls
expanded mesangial matrix ( J:127199 )
• at 20 weeks of age, markedly expanded mesangium due to mesangial matrix increase is observed
glomerular crescent ( J:127199 )
• at 20 weeks of age, proliferation of lining of Bowman's capsule is observed
renal glomerular synechia ( J:127199 )
• at 20 weeks of age, proliferation of lining of Bowman's capsule with fusion of the tuft (synechia) is observed
renal glomerulus fibrosis ( J:127199 )
• at 20 weeks of age, severely affected glomeruli exhibit fibrin deposition
renal tubule atrophy ( J:127199 )
• at 20 weeks of age, mild multifocal tubular atrophy is observed
renal necrosis ( J:127199 )
• at 20 weeks of age, severely affected glomeruli display necrosis of large areas of the tuft
kidney failure ( J:127199 )
• progressive decline in renal function is observed, during progression to end-stage renal disease

cardiovascular system
abnormal glomerular capillary endothelium morphology ( J:127199 )
• at 20 weeks of age, proliferation of endothelial cells is observed

integument
dermatitis ( J:127199 )
• double mutants show more rapid onset of cutaneous inflammation than Faslpr homozygotes

cellular
increased mesangial cell number ( J:127199 )
• at 20 weeks of age, cellularity of mesangium is moderately increased
abnormal leukocyte adhesion ( J:126009 )
• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
impaired leukocyte tethering or rolling ( J:126009 )
• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory