Phenotypes associated with this allele

• Allele Symbol: Selp^tm1Hyn
• Allele Name: targeted mutation 1, Richard Hynes
• Allele ID: MGI:1857245
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas	MGI:3699544
hm2	Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840199
hm3	Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6J	MGI:3699357
cx4	Sele^tm1Hyn/Sele^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas	MGI:3699612
cx5	Sell^tm3Hyn/Sell^tm3Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840202
cx6	Sell^tm4Hyn/Sell^tm4Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840203
cx7	Sele^tm1Hyn/Sele^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840205
cx8	Sele^tm1Hyn/Sele^tm1Hyn Sell^tm1Hyn/Sell^tm1Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840206

Genotype
MGI:3699544

hm1

• Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage chemotaxis ( J:29814 )

• macrophage recruitment in a peritonitis model is reduced even 48 hours after challenge

impaired leukocyte tethering or rolling ( J:29814 )

• rolling of leukocytes in subcutaneous vessels is significantly lower under both basal conditions and post-ischemia-reperfusion, but not completely eliminated

• leukocyte rolling is reduced even four hours after challenge; exhibit significantly fewer rolling cells and their velocity is reduced

increased neutrophil cell number ( J:29814 )

• increased numbers of circulating neutrophils

• clearing of neutrophils from the circulation is delayed in the first 2 to 3 hours after neutrophil injection, but is normal by 5 hours

hematopoietic system

impaired macrophage chemotaxis ( J:29814 )

• macrophage recruitment in a peritonitis model is reduced even 48 hours after challenge

impaired leukocyte tethering or rolling ( J:29814 )

• rolling of leukocytes in subcutaneous vessels is significantly lower under both basal conditions and post-ischemia-reperfusion, but not completely eliminated

• leukocyte rolling is reduced even four hours after challenge; exhibit significantly fewer rolling cells and their velocity is reduced

increased neutrophil cell number ( J:29814 )

• increased numbers of circulating neutrophils

• clearing of neutrophils from the circulation is delayed in the first 2 to 3 hours after neutrophil injection, but is normal by 5 hours

cellular

impaired macrophage chemotaxis ( J:29814 )

• macrophage recruitment in a peritonitis model is reduced even 48 hours after challenge

impaired leukocyte tethering or rolling ( J:29814 )

• rolling of leukocytes in subcutaneous vessels is significantly lower under both basal conditions and post-ischemia-reperfusion, but not completely eliminated

• leukocyte rolling is reduced even four hours after challenge; exhibit significantly fewer rolling cells and their velocity is reduced

Genotype
MGI:3840199

hm2

• Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• there is a third decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF

• there is also a third decrease in the number of adhering leukocytes within these mesenteric venules

• mean velocity of leukocytes is decreased

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about two-thirds higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are slightly increased

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• there is a third decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF

• there is also a third decrease in the number of adhering leukocytes within these mesenteric venules

• mean velocity of leukocytes is decreased

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about two-thirds higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are slightly increased

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• there is a third decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF

• there is also a third decrease in the number of adhering leukocytes within these mesenteric venules

• mean velocity of leukocytes is decreased

Genotype
MGI:3699357

hm3

• Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

immune system

impaired leukocyte tethering or rolling ( J:77329 )

• exhibit virtually total absence of leukocyte rolling in mesenteric venules

• two secretagogues (the calcium ionophore A23187 and hydrogen peroxide) that result in increased rolling in wild-type fail to stimulate any significant rolling in homozygotes

increased neutrophil cell number ( J:77329 )

• exhibit a 2.4-fold increase in circulating neutrophil counts

impaired neutrophil recruitment ( J:77329 )

• exhibit delayed recruitment of neutrophils to the peritoneal cavity upon experimentally induced inflammation

hematopoietic system

impaired leukocyte tethering or rolling ( J:77329 )

• exhibit virtually total absence of leukocyte rolling in mesenteric venules

• two secretagogues (the calcium ionophore A23187 and hydrogen peroxide) that result in increased rolling in wild-type fail to stimulate any significant rolling in homozygotes

increased neutrophil cell number ( J:77329 )

• exhibit a 2.4-fold increase in circulating neutrophil counts

impaired neutrophil recruitment ( J:77329 )

• exhibit delayed recruitment of neutrophils to the peritoneal cavity upon experimentally induced inflammation

homeostasis/metabolism

increased bleeding time ( J:31431 )

• exhibit a 40% prolongation of the bleeding time on amputation of the tip of the tail

cardiovascular system

skin hemorrhage ( J:31431 )

• hemorrhagic skin lesions induced by injection of lipopolysaccharide followed by tumor necrosis factor are larger by a factor of two compared to controls

cellular

impaired leukocyte tethering or rolling ( J:77329 )

• exhibit virtually total absence of leukocyte rolling in mesenteric venules

• two secretagogues (the calcium ionophore A23187 and hydrogen peroxide) that result in increased rolling in wild-type fail to stimulate any significant rolling in homozygotes

integument

skin hemorrhage ( J:31431 )

• hemorrhagic skin lesions induced by injection of lipopolysaccharide followed by tumor necrosis factor are larger by a factor of two compared to controls

Genotype
MGI:3699612

cx4

• Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas

mortality/aging

premature death ( J:31626 )

• fatalities are seen in mutants older than 3 months of age that develop bacterial dermatitis

hematopoietic system

impaired leukocyte tethering or rolling ( J:31626 )

• leukocyte rolling along mesenteric venules is virtually absent in these mice

• TNF pre-treatment leads to a slight increase in rolling though the rolling flux is 46-fold less than in controls

• the velocity of the rare leukocyte that does bind is much greater than those in wld-type

• the number of adhering leukocytes is 6-fold less than controls

increased spleen weight ( J:31626 )

• splenic weights are increased about 2-fold

spleen hyperplasia ( J:31626 )

• spleens contain 2-fold more cells

abnormal definitive hematopoiesis ( J:31626 )

• differentiating myeloid precursors are significantly more numerous, however blast forms are not increased, and precursor cells from the erythroid lineage are less numerous in the bone marrow, resulting in a myeloid to erythroid ratio that is increased more than 5-fold

abnormal common myeloid progenitor cell morphology ( J:31626 )

• spleens contain increased numbers of CFU-GM

abnormal erythropoiesis ( J:31626 )

• erythropoiesis is partially translocated to the spleen

abnormal myelopoiesis ( J:31626 )

• myeloid precursor are more numerous in the bone marrow

• the myeloid to erythroid ratio is increased more than 5-fold in these mice

abnormal granulocyte differentiation ( J:31626 )

• neutrophilic granulocytes compromise most of the cells of the bone marrow with an average of 60% of cells containing the segmented bands and rings morphology as compared to 42% in wild-type mice

extramedullary hematopoiesis ( J:31626 )

• increased extramedullary hematopoietic activity in the spleen

• 3 of 10 show evidence of extramedullary hematopoietic activity in the liver

impaired hematopoiesis ( J:31626 )

• precursor cells of the erythroid lineage are under represented in the bone marrow

increased erythroid progenitor cell number ( J:31626 )

• the number of BFU-E in the spleen are significantly increased

increased leukocyte cell number ( J:31626 )

• there is a 3.9-fold elevation in the mean number of leukocytes in the blood

increased eosinophil cell number ( J:31626 )

• eosinophil numbers are increased 6.3-fold

increased neutrophil cell number ( J:31626 )

• more than 16-fold increase in mature polymorphonuclear neutrophils

• neonates exhibit a 3.3-fold increase in neutrophil numbers

increased lymphocyte cell number ( J:31626 )

• lymphocyte numbers are increased 1.5-fold

increased monocyte cell number ( J:31626 )

• monocyte numbers are increased 9.8-fold in the blood

increased spleen red pulp amount ( J:31626 )

• expanded red pulp

impaired neutrophil recruitment ( J:31626 )

• neutrophil recruitment in an induced peritonitis model is reduced

• there is a five-fold impairment in the number of neutrophils recruited by thioglycollate injection

• fewer than expected neutrophils are found at the site of skin lesions

immune system

impaired leukocyte tethering or rolling ( J:31626 )

• leukocyte rolling along mesenteric venules is virtually absent in these mice

• TNF pre-treatment leads to a slight increase in rolling though the rolling flux is 46-fold less than in controls

• the velocity of the rare leukocyte that does bind is much greater than those in wld-type

• the number of adhering leukocytes is 6-fold less than controls

increased spleen weight ( J:31626 )

• splenic weights are increased about 2-fold

spleen hyperplasia ( J:31626 )

• spleens contain 2-fold more cells

abnormal myelopoiesis ( J:31626 )

• myeloid precursor are more numerous in the bone marrow

• the myeloid to erythroid ratio is increased more than 5-fold in these mice

abnormal granulocyte differentiation ( J:31626 )

• neutrophilic granulocytes compromise most of the cells of the bone marrow with an average of 60% of cells containing the segmented bands and rings morphology as compared to 42% in wild-type mice

increased leukocyte cell number ( J:31626 )

• there is a 3.9-fold elevation in the mean number of leukocytes in the blood

increased eosinophil cell number ( J:31626 )

• eosinophil numbers are increased 6.3-fold

increased neutrophil cell number ( J:31626 )

• more than 16-fold increase in mature polymorphonuclear neutrophils

• neonates exhibit a 3.3-fold increase in neutrophil numbers

increased lymphocyte cell number ( J:31626 )

• lymphocyte numbers are increased 1.5-fold

increased monocyte cell number ( J:31626 )

• monocyte numbers are increased 9.8-fold in the blood

increased spleen red pulp amount ( J:31626 )

• expanded red pulp

impaired neutrophil recruitment ( J:31626 )

• neutrophil recruitment in an induced peritonitis model is reduced

• there is a five-fold impairment in the number of neutrophils recruited by thioglycollate injection

• fewer than expected neutrophils are found at the site of skin lesions

abnormal cytokine level ( J:31626 )

• exhibit a 5-fold elevation in GM-CSF levels

increased circulating interleukin-3 level ( J:31626 )

• mice have 40-fold higher levels of circulating IL-3 than controls

increased susceptibility to bacterial infection ( J:31626 )

• show a high prevalence of spontaneous bacterial dermatitis with or without ulceration, with the majority of mutants 4 months or older developing dermatitis

homeostasis/metabolism

abnormal cytokine level ( J:31626 )

• exhibit a 5-fold elevation in GM-CSF levels

increased circulating interleukin-3 level ( J:31626 )

• mice have 40-fold higher levels of circulating IL-3 than controls

cellular

abnormal granulocyte differentiation ( J:31626 )

• neutrophilic granulocytes compromise most of the cells of the bone marrow with an average of 60% of cells containing the segmented bands and rings morphology as compared to 42% in wild-type mice

impaired leukocyte tethering or rolling ( J:31626 )

• leukocyte rolling along mesenteric venules is virtually absent in these mice

• TNF pre-treatment leads to a slight increase in rolling though the rolling flux is 46-fold less than in controls

• the velocity of the rare leukocyte that does bind is much greater than those in wld-type

• the number of adhering leukocytes is 6-fold less than controls

growth/size/body

increased spleen weight ( J:31626 )

• splenic weights are increased about 2-fold

spleen hyperplasia ( J:31626 )

• spleens contain 2-fold more cells

Genotype
MGI:3840202

cx5

• Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

increased leukocyte cell number ( J:57973 )

• leukocyte numbers are slightly increased

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 4-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are slightly increased

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

increased leukocyte cell number ( J:57973 )

• leukocyte numbers are slightly increased

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 4-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are slightly increased

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

Genotype
MGI:3840203

cx6

• Allelic Composition: Sell^tm4Hyn/Sell^tm4Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about two-thirds higher in the blood

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observedat 2 hours than those elicited from mice that are null homozygotes for just one gene

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about two-thirds higher in the blood

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observedat 2 hours than those elicited from mice that are null homozygotes for just one gene

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

Genotype
MGI:3840205

cx7

• Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a decrease of about half in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased leukocyte cell number ( J:57973 )

• leukocyte numbers are increased about 50%

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 7-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are increased around 5-fold

increased monocyte cell number ( J:57973 )

• monocyte number are increased about 4-fold

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a decrease of about half in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased leukocyte cell number ( J:57973 )

• leukocyte numbers are increased about 50%

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 7-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are increased around 5-fold

increased monocyte cell number ( J:57973 )

• monocyte number are increased about 4-fold

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a decrease of about half in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

Genotype
MGI:3840206

cx8

• Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn; Sell^tm1Hyn/Sell^tm1Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased leukocyte cell number ( J:57973 )

• there is a 2.5 fold increase in leukocyte numbers

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 6-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are increased almost 10-fold

increased monocyte cell number ( J:57973 )

• monocyte number are increased about 5-fold

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice

increased leukocyte cell number ( J:57973 )

• there is a 2.5 fold increase in leukocyte numbers

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 6-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are increased almost 10-fold

increased monocyte cell number ( J:57973 )

• monocyte number are increased about 5-fold

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules

• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice