Phenotypes associated with this allele

• Allele Symbol: Spn^tm1Bam
• Allele Name: targeted mutation 1, Blair Ardman
• Allele ID: MGI:1857246
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spn^tm1Bam/Spn^tm1Bam	B6;129S4-Spn^tm1Bam/J	MGI:3029970
hm2	Spn^tm1Bam/Spn^tm1Bam	involves: 129S4/SvJae * C57BL/6	MGI:3029969

Genotype
MGI:3029970

hm1

• Allelic Composition: Spn^tm1Bam/Spn^tm1Bam
• Genetic Background: B6;129S4-Spn^tm1Bam/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:88253 )

• resistance to melanoma growth and metastasis in the short-term; this resistance decreases over time

immune system

immune system phenotype ( J:66401 )

N • T cell proliferative responses are similar to controls

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:86932 )

• mice exhibited a delayed onset and reduced severity of induced experimental autoimmune encephalitis (EAE)

Genotype
MGI:3029969

hm2

• Allelic Composition: Spn^tm1Bam/Spn^tm1Bam
• Genetic Background: involves: 129S4/SvJae * C57BL/6

hematopoietic system

hematopoietic system phenotype ( J:29272 )

N • homozygous mice exhibit normal hematocrit, and normal leukocyte and platelet counts

N • T lymphocyte development was normal; normal proportions of CD4 and CD8 subsets were present

N • B cell development was normal

abnormal T cell physiology ( J:29272 )

• enhanced T cell homotypic adhesion; enhanced binding to purified ligands

increased T cell proliferation ( J:29272 , J:88252 )

• increased T cell proliferation was noted in response to various stimulation agents and natural antigens (J:29272)

• increased T cell proliferation in response to various stimulators (J:88252)

immune system

abnormal T cell physiology ( J:29272 )

• enhanced T cell homotypic adhesion; enhanced binding to purified ligands

increased T cell proliferation ( J:29272 , J:88252 )

• increased T cell proliferation was noted in response to various stimulation agents and natural antigens (J:29272)

• increased T cell proliferation in response to various stimulators (J:88252)

cellular

increased T cell proliferation ( J:29272 , J:88252 )

• increased T cell proliferation was noted in response to various stimulation agents and natural antigens (J:29272)

• increased T cell proliferation in response to various stimulators (J:88252)