All Phenotypes Src<tm1Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Src^tm1Sor/Src^tm1Sor	B6.129S7-Src^tm1Sor/J	MGI:3819969
hm2	Src^tm1Sor/Src^tm1Sor	either: 129S7/SvEvBrd-Src^tm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)	MGI:2174746
cx3	Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src⁺	involves: 129S7/SvEvBrd	MGI:3574822
cx4	Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src^tm1Sor	involves: 129S7/SvEvBrd	MGI:3795906
cx5	Src^tm1Sor/Src^tm1Sor Yes1^tm1Sor/Yes1^tm1Sor	involves: 129S7/SvEvBrd	MGI:3795907
cx6	Hck^tm1Hev/Hck^tm1Hev Src^tm1Sor/Src^tm1Sor	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3623221

Allelic Composition	Src^tm1Sor/Src^tm1Sor
Genetic Background	B6.129S7-Src^tm1Sor/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Src^tm1Sor mutation (2 available); any Src mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal decidualization ( J:104318 )

• ovariectomized female homozygotes treated with a low dose of estrogen (E2) and a high dose of progesterone (P4), followed by mechanical stimulation of the left uterine horn, showed little or no detectable decidual responses relative to similarly-treated wild-type and heterozygous females, as determined by uterine histology and uterine weight changes

• in vitro, endometrial stromal cells (ESCs) from wild-type mice became morphologically decidualized when cultured in the presence of E2+P4 for 5 days, whereas ESCs from female homozygotes remained morphologically unchanged

• however, prolonged treatment with E2+P4 for 10 days elicited both functional and morphological decidualization even in homozygous mutant ESCs

female infertility ( J:104318 )

• female homozygotes are severely subfertile or infertile, partly due to impaired decidualization resulting from the loss of maternal function in endometrial stromal cells

embryo

abnormal decidualization ( J:104318 )

• however, prolonged treatment with E2+P4 for 10 days elicited both functional and morphological decidualization even in homozygous mutant ESCs

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:67040 )

• most animals died at 3-4 weeks of age if weaned; one-third of mice could be maintained past 5 weeks if not weaned and kept on a soft food diet

• Background Sensitivity: mice on a mixed background survive longer than mice on the inbred 129S7/SvEvBrd genetic background

postnatal lethality, incomplete penetrance ( J:67040 )

• at 3 weeks of age, only 19% of the mice are homozygous, suggesting a partial prenatal and/or partial early postnatal lethality

growth/size/body

absent incisors ( J:67040 )

• incisors are absent at 3 weeks of age

• incisor teeth are well developed, but fail to erupt through the gum

abnormal tooth eruption ( J:67040 )

• some molar teeth show partial eruption, but are crowded by osseous growth of the facial bones

failure of tooth eruption ( J:67040 )

• incisor teeth are well developed, but fail to erupt through the gum

broad face ( J:67040 )

• mice have a broad face

abnormal head shape ( J:67040 )

• mice have a slightly domed head

decreased body size ( J:67040 )

• by 10-12 days of age, mice are noticeably smaller than controls

decreased body weight ( J:67040 )

• mice grow more slowly and weigh about one-third to one-half as much as controls

skeleton

abnormal craniofacial bone morphology ( J:67040 )

• facial bones are thickened by fibrous and osseous tissue proliferation and lack of bone resorbtion

• smaller airway lumina are present due to abnormal facial bone morphology

absent incisors ( J:67040 )

• incisors are absent at 3 weeks of age

• incisor teeth are well developed, but fail to erupt through the gum

abnormal tooth eruption ( J:67040 )

• some molar teeth show partial eruption, but are crowded by osseous growth of the facial bones

failure of tooth eruption ( J:67040 )

• incisor teeth are well developed, but fail to erupt through the gum

abnormal long bone morphology ( J:67040 )

abnormal long bone diaphysis morphology ( J:67040 )

• short diaphysis of the long bones

increased long bone epiphyseal plate size ( J:67040 )

• thickened growth plates in the long bones

decreased length of long bones ( J:67040 )

• long bones are shorter in length

abnormal bone structure ( J:67040 )

abnormal bone marrow cavity morphology ( J:67040 )

• the bone marrow cavity was filled with little room for hematopoietic elements

abnormal bone marrow morphology ( J:67040 )

• partial absence of bone marrow

decreased compact bone thickness ( J:67040 )

• cortical bone is thinner and disorganized

abnormal bone trabecula morphology ( J:67040 )

• the central trabeculae consist of calcified cartilage

increased trabecular bone mass ( J:67040 )

• there is a widening and extension of the trabecular bone deep into the distal metaphysis and diaphysis

osteopetrosis ( J:67040 )

• noted in calvarium, nasal turbinates, facial bones, mandible, tibia and femurs; obvious in long bones at P10 and in the crainial bones at birth

delayed endochondral bone ossification ( J:67040 )

• persistence of endochondrial primary spongiosa

decreased bone resorption ( J:67040 )

• bone resorption is minimal to absent

pigmentation

diluted coat color ( J:67040 )

• Background Sensitivity: mice on a mixed genetic background exhibit a lighter coat color unlike mice on an inbred 129S7/SvEvBrd genetic background

vision/eye

abnormal anterior eye segment morphology ( J:67040 )

• at later ages, the eyes are frequently cloudy due to secreted material

delayed eyelid opening ( J:67040 )

hematopoietic system

hematopoietic system phenotype ( J:67040 )

• normal platelet counts are seen

• normal red and white cell parameters are seen

• no evidence of hemorrhage or platelet dysfunction is seen; mice are capable of wound healing following tail or toe clipping

• the liver and spleen are normal in size

• parafollicular cells of the thyroid are normal

• Kuppfer cells in the liver are normal in quantity and morphology

nervous system

nervous system phenotype ( J:67040 )

N	• no microscopic brain lesions are apparent in multiple substructures • general brain architecture is normal and axon extension and fasciculation appear normal

immune system

increased inflammatory response ( J:67040 )

• necrotic debris and acute inflammatory cells are sometimes seen within the lumen of the nasolacrimal duct

periodontium inflammation ( J:67040 )

• suppurative periodontal inflammation is seen in some animals

craniofacial

abnormal craniofacial bone morphology ( J:67040 )

• facial bones are thickened by fibrous and osseous tissue proliferation and lack of bone resorbtion

• smaller airway lumina are present due to abnormal facial bone morphology

absent incisors ( J:67040 )

• incisors are absent at 3 weeks of age

• incisor teeth are well developed, but fail to erupt through the gum

abnormal tooth eruption ( J:67040 )

• some molar teeth show partial eruption, but are crowded by osseous growth of the facial bones

failure of tooth eruption ( J:67040 )

• incisor teeth are well developed, but fail to erupt through the gum

broad face ( J:67040 )

• mice have a broad face

abnormal head shape ( J:67040 )

• mice have a slightly domed head

limbs/digits/tail

abnormal limb morphology ( J:67040 )

• enlarged, club-shaped extremities

integument

diluted coat color ( J:67040 )

• Background Sensitivity: mice on a mixed genetic background exhibit a lighter coat color unlike mice on an inbred 129S7/SvEvBrd genetic background

Allelic Composition	Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyn^tm1Sor mutation (3 available); any Fyn mutation (39 available)
Src^tm1Sor mutation (2 available); any Src mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nursing ( J:20346 )

• difficulty in nursing newborn pups on the occasional cases where females became pregnant

reproductive system

reduced female fertility ( J:20346 )

Allelic Composition	Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src^tm1Sor
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:20346 )

• only 10% of animals survived to weaning age; normal Mendelian ratios were present at E18.5; animals did not survive past 3 weeks of age

growth/size/body

decreased body size ( J:20346 )

• animals were described as very small

decreased body weight ( J:20346 )

• at 3 weeks of age, animals weighed 3-4 grams compared to controls weighing 8 grams

Allelic Composition	Src^tm1Sor/Src^tm1Sor Yes1^tm1Sor/Yes1^tm1Sor
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Src^tm1Sor mutation (2 available); any Src mutation (146 available)
Yes1^tm1Sor mutation (1 available); any Yes1 mutation (138 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:20346 )

• some animals survived past weaning age; one survived to one year of age on a soft food diet

neonatal lethality, incomplete penetrance ( J:20346 )

• incomplete penetrance; only 10% of animals survived to weaning age; normal Mendelian ratios were present at E18.5, but many were found dead shortly after birth

growth/size/body

decreased body size ( J:20346 )

• embryos at E18.5 were approximately 25% smaller than controls despite normal placenta morphology

respiratory system

abnormal breathing pattern ( J:20346 )

• animals delivered by Cesarean at E18.5 only started to breathe normally after one hour of prodding

skeleton

osteopetrosis ( J:20346 )

• no more severe than in homozygous Src mutant mice

Allelic Composition	Hck^tm1Hev/Hck^tm1Hev Src^tm1Sor/Src^tm1Sor
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hck^tm1Hev mutation (0 available); any Hck mutation (31 available)
Src^tm1Sor mutation (2 available); any Src mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:31647 )

• approximately 50% die immediately after weaning

perinatal lethality, incomplete penetrance ( J:31647 )

• double homozygotes present at dramatically reduced proportions at 10-14 days of age

• ratios normal at E18.5

• deaths probably occurring perinatally

growth/size/body

postnatal growth retardation ( J:31647 )

• little weight gain from 14 to 50 days of age

skeleton

abnormal long bone diaphysis morphology ( J:31647 )

• proximal and distal growth zones are often fused leaving the diaphysis filled with cancellous bone

abnormal bone marrow cavity morphology ( J:31647 )

• reduced bone marrow cavity

abnormal trabecular bone morphology ( J:31647 )

• extensive development of cancellous bone reduces bone marrow cavity in long bones, vertebral bodies, sternum

• accumulations of poorly remodeled osteocartilagenous trabeculae throughout the growth zones of long bones

abnormal skeleton development ( J:31647 )

• proximal and distal growth zones are often fused leaving the diaphysis filled with cancellous bone

• normal numbers of osteoclasts found

immune system

increased macrophage cell number ( J:31647 )

• accumulation of mature macrophage in bones

decreased leukocyte cell number ( J:31647 )

• mild leucopenia at 2-4 weeks of age which is more severe at E18.5

abnormal immune system organ morphology ( J:31647 )

thymus hypoplasia ( J:31647 )

• reduced cell number in thymus

abnormal spleen morphology ( J:31647 )

abnormal spleen germinal center morphology ( J:31647 )

• absent or poorly formed germinal centers

abnormal splenic cell ratio ( J:31647 )

• increased number of colony forming units in spleen

• greatly increased numbers of immature myeloid cells

• decreased numbers of lymphoid cells

lymph node hypoplasia ( J:31647 )

• reduced number of cells in lymph nodes but structure otherwise normal

hematopoietic system

thymus hypoplasia ( J:31647 )

• reduced cell number in thymus

anemia ( J:31647 )

• mild anemia at 2-4 weeks of age which is more severe at E18.5

decreased bone marrow cell number ( J:31647 )

• reduced number of colony forming units in bone marrow

increased macrophage cell number ( J:31647 )

• accumulation of mature macrophage in bones

decreased leukocyte cell number ( J:31647 )

• mild leucopenia at 2-4 weeks of age which is more severe at E18.5

abnormal spleen morphology ( J:31647 )

abnormal spleen germinal center morphology ( J:31647 )

• absent or poorly formed germinal centers

abnormal splenic cell ratio ( J:31647 )

• increased number of colony forming units in spleen

• greatly increased numbers of immature myeloid cells

• decreased numbers of lymphoid cells

endocrine/exocrine glands

thymus hypoplasia ( J:31647 )

• reduced cell number in thymus

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