All Phenotypes Stat4<tm1Gru> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat4^tm1Gru/Stat4^tm1Gru	C.129S2-Stat4^tm1Gru	MGI:3617977
hm2	Stat4^tm1Gru/Stat4^tm1Gru	involves: 129S2/SvPas	MGI:3851529
hm3	Stat4^tm1Gru/Stat4^tm1Gru	involves: 129S2/SvPas * BALB/c	MGI:3617974
hm4	Stat4^tm1Gru/Stat4^tm1Gru	NOD.129S2-Stat4^tm1Gru	MGI:3617975
ht5	Stat4^tm1Gru/Stat4⁺	NOD.129S2-Stat4^tm1Gru	MGI:3617976
ht6	Stat4^ity14/Stat4^tm1Gru	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:5578205
cx7	Stat4^tm1Gru/Stat4^tm1Gru Tg(Ins2-NP)25-3Olds/0	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:3620118
cx8	Stat4^tm1Gru/Stat4^tm1Gru Tg(Ins2-GP)34-20Olds/0	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:3620122

Allelic Composition	Stat4^tm1Gru/Stat4^tm1Gru
Genetic Background	C.129S2-Stat4^tm1Gru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:143729 )

• wild-type CD4⁺ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12

• mutant polarized Th17 CD4⁺ T cells fail to convert to the Th1-like state in the presence of IL-12

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:143729 )

• wild-type CD4⁺ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12

• mutant polarized Th17 CD4⁺ T cells fail to convert to the Th1-like state in the presence of IL-12

renal/urinary system

abnormal kidney physiology ( J:84825 )

• onset of ischemia effects is delayed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:106340

Allelic Composition	Stat4^tm1Gru/Stat4^tm1Gru
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:112600 )

• T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce less IL-4 and interferon gamma than wild-type in response to KLH restimulation; IL-17a levels are comparable to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:163843 )

• Salmonella-infected mice exhibit increased mortality compared with similarly treated heterozygous or wild-type mice

immune system

abnormal lymphocyte physiology ( J:34059 )

abnormal T cell proliferation ( J:34059 )

• activated T lymphocytes stimulated with IL-12 for 48 hours do not proliferate, whereas activated lymphocytes from control mice exhibit dose-dependent proliferation

abnormal NK cell physiology ( J:34059 )

• IL-12 stimulated NK cells do not show enhanced cytotoxicity compared to unstimulated cells, while stimulated control cells show a significant enhancement (30% specific lysis compared to 10% in unstimulated control cells)

abnormal T-helper 1 physiology ( J:34059 )

• cultured lymphocytes differentiated into Th1 cells by anti-CD3 or heat-killed Listeria monocytogenes produce less than 20% of the IFNG produced by control cells; lymphotoxin production also is significantly reduced compared to control cells

• significant levels of Th2 cytokines IL-5 and IL-10 are detected in supernatants from these cultured lymphocytes

abnormal T-helper 2 physiology ( J:34059 )

• lymphocytes cultured in the presence of IL-4 and IFNG produce significantly higher levels of Th2 cytokines than control cells

decreased circulating interferon-gamma level ( J:163843 )

• in Salmonella-infected mice

decreased interferon-gamma secretion ( J:34059 )

• following Il-2 stimulation for 24 hours, lymphocytes from mutants do not show increased IFNG levels compared to a 15-fold increase seen in activated cells from control mice

increased susceptibility to bacterial infection ( J:163843 )

• Salmonella-infected mice exhibit increased mortality, increased organ bacterial burden, and decreased IFN-gamma levels compared with similarly treated heterozygous or wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:163843 )

• Salmonella-infected mice exhibit increased mortality compared with similarly treated heterozygous or wild-type mice

hematopoietic system

abnormal lymphocyte physiology ( J:34059 )

abnormal T cell proliferation ( J:34059 )

• activated T lymphocytes stimulated with IL-12 for 48 hours do not proliferate, whereas activated lymphocytes from control mice exhibit dose-dependent proliferation

abnormal NK cell physiology ( J:34059 )

abnormal T-helper 1 physiology ( J:34059 )

• significant levels of Th2 cytokines IL-5 and IL-10 are detected in supernatants from these cultured lymphocytes

abnormal T-helper 2 physiology ( J:34059 )

• lymphocytes cultured in the presence of IL-4 and IFNG produce significantly higher levels of Th2 cytokines than control cells

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:163843 )

• in Salmonella-infected mice

cellular

abnormal T cell proliferation ( J:34059 )

• activated T lymphocytes stimulated with IL-12 for 48 hours do not proliferate, whereas activated lymphocytes from control mice exhibit dose-dependent proliferation

Allelic Composition	Stat4^tm1Gru/Stat4^tm1Gru
Genetic Background	NOD.129S2-Stat4^tm1Gru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG is seen compared to diabetic and non-diabetic NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• a reduction in the serum level of IL-2 is observed compared to diabetic and non-diabetic NOD mice

decreased susceptibility to autoimmune diabetes ( J:90600 )

• no female mutants develop diabetes (blood glucose levels above 13.9 mmol/l for 3 readings) over a 10-month period compared with 74% of female wild-type Stat4 NOD mice, which is similar to female NOD mice (80%)

abnormal inflammatory response ( J:90600 )

• noc cellular infiltration is observed at 40 weeks of age compared to massive and invasive cellular infiltration seen in diabetic NOD controls and heterozygous Stat4 NOD or wild-type Stat4 mice

• a significant reduction in the numbers of CD4+ and CD8+ cells in islets is observed compared to diabetic NOD mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:90600 )

• well-preserved insulin-positive cells are seen in the islets of mutants whereas such cells are rare in Stat4 heterozygous and wild-type Stat4 NOD mice

abnormal insulin secretion ( J:90600 )

• compared to NOD controls, islets in Stat4 null NOD mice show well preserved insulin secretion at basal glucose levels and in response to high glucose

homeostasis/metabolism

abnormal insulin secretion ( J:90600 )

• compared to NOD controls, islets in Stat4 null NOD mice show well preserved insulin secretion at basal glucose levels and in response to high glucose

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG is seen compared to diabetic and non-diabetic NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• a reduction in the serum level of IL-2 is observed compared to diabetic and non-diabetic NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:90600

Allelic Composition	Stat4^tm1Gru/Stat4⁺
Genetic Background	NOD.129S2-Stat4^tm1Gru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:90600 )

• a significant decrease in the incidence of diabetes (30%) is observed compared with wild-type Stat4 NOD mice (74%); diabetes is diagnosed when 3 blood glucose measures are equal to or higher than 13.9 mmol/l

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:90600

Allelic Composition	Stat4^ity14/Stat4^tm1Gru
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^ity14 mutation (0 available); any Stat4 mutation (64 available)
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection induced morbidity/mortality ( J:207092 )

• mice infected with Salmonella Typhimurium exhibit increased lethality compared with wild-type mice

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:207092 )

• mice infected with Salmonella Typhimurium exhibit increased lethality compared with wild-type mice

Allelic Composition	Stat4^tm1Gru/Stat4^tm1Gru Tg(Ins2-NP)25-3Olds/0
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)
Tg(Ins2-NP)25-3Olds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

insulitis ( J:107047 )

• mutants have a lower degree of insulitis

abnormal cytotoxic T cell physiology ( J:107047 )

• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV

decreased interferon-gamma secretion ( J:107047 )

• splenocytes are unresponsive to IL-12 stimulation and do not produce significant levels oi IFNgamma

decreased susceptibility to autoimmune diabetes ( J:107047 )

• a significant reduction in CD4+ T cell-dependent (2 consecutive measures of blood glucose >250 mg/dl) diabetes incidence is observed in mutants (30%) versus controls (85%) when infected with LCMV to induce IDDM

endocrine/exocrine glands

insulitis ( J:107047 )

• mutants have a lower degree of insulitis

hematopoietic system

abnormal cytotoxic T cell physiology ( J:107047 )

• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:107047

Allelic Composition	Stat4^tm1Gru/Stat4^tm1Gru Tg(Ins2-GP)34-20Olds/0
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4^tm1Gru mutation (4 available); any Stat4 mutation (64 available)
Tg(Ins2-GP)34-20Olds mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal susceptibility to autoimmune disorder ( J:107047 )

• Stat4 deficiency does not affect the incidence of CD4+ T cell independent diabetes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:107047

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