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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat5atm1Mam
targeted mutation 1, Lothar Hennighausen
MGI:1857249
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat5atm1Mam/Stat5atm1Mam C.129S6-Stat5atm1Mam MGI:3687968
hm2
 		Stat5atm1Mam/Stat5atm1Mam either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss) MGI:3687955
hm3
 		Stat5atm1Mam/Stat5atm1Mam involves: 129S6/SvEvTac MGI:3687963
hm4
 		Stat5atm1Mam/Stat5atm1Mam involves: 129S6/SvEvTac * C57BL/6 MGI:3688422


Genotype
MGI:3687968
hm1
Allelic
Composition		 Stat5atm1Mam/Stat5atm1Mam
Genetic
Background		 C.129S6-Stat5atm1Mam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Mam mutation (3 available); any Stat5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell morphology ( J:101855 )
• IL-3-induced but not stem cell factor-induced proliferation of bone marrow derived mast cells is significantly diminished
• survival rates of both peritoneal mast cells and bone marrow derived mast cells are decreased and apoptotic cells are increased
abnormal mast cell differentiation ( J:101855 )
• the IL-3-dependent development of bone marrow derived mast cells is decreased
decreased mast cell number ( J:101855 )
• decrease in the number of mast cells in the peritoneal cavity, ear and stomach

hematopoietic system
abnormal mast cell morphology ( J:101855 )
• IL-3-induced but not stem cell factor-induced proliferation of bone marrow derived mast cells is significantly diminished
• survival rates of both peritoneal mast cells and bone marrow derived mast cells are decreased and apoptotic cells are increased
abnormal mast cell differentiation ( J:101855 )
• the IL-3-dependent development of bone marrow derived mast cells is decreased
decreased mast cell number ( J:101855 )
• decrease in the number of mast cells in the peritoneal cavity, ear and stomach

cellular
abnormal mast cell differentiation ( J:101855 )
• the IL-3-dependent development of bone marrow derived mast cells is decreased




Genotype
MGI:3687955
hm2
Allelic
Composition		 Stat5atm1Mam/Stat5atm1Mam
Genetic
Background		 either: 129S6/SvEvTac-Stat5atm1Mam or (involves: 129S6/SvEvTac * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Mam mutation (3 available); any Stat5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:64278 )
• ductal development appears normal but lobuloalveolar outgrowth is severely reduced, secretory tissue is sparse, and alveoli are petite and contain small lumina
abnormal mammary gland growth during lactation ( J:64278 )
• lubuloalveolar units are underdeveloped and do not exhibit a secretory phenotype, even after maximal stimulation of prolactin secretion induced by suckling
abnormal mammary gland growth during pregnancy ( J:64278 )
• mammary lobuloalveolar outgrowth during pregnancy is curtailed
lactation failure ( J:64278 )
• females fail to lactate after parturition because of a failure of terminal differentiation
• continued suckling does not result in milk production and release, however expression of milk protein genes and synthesis of milk proteins is maintained and the gland does not involute

reproductive system
abnormal mammary gland growth during pregnancy ( J:64278 )
• mammary lobuloalveolar outgrowth during pregnancy is curtailed

integument
abnormal branching of the mammary ductal tree ( J:64278 )
• ductal development appears normal but lobuloalveolar outgrowth is severely reduced, secretory tissue is sparse, and alveoli are petite and contain small lumina
abnormal mammary gland growth during lactation ( J:64278 )
• lubuloalveolar units are underdeveloped and do not exhibit a secretory phenotype, even after maximal stimulation of prolactin secretion induced by suckling
abnormal mammary gland growth during pregnancy ( J:64278 )
• mammary lobuloalveolar outgrowth during pregnancy is curtailed
lactation failure ( J:64278 )
• females fail to lactate after parturition because of a failure of terminal differentiation
• continued suckling does not result in milk production and release, however expression of milk protein genes and synthesis of milk proteins is maintained and the gland does not involute




Genotype
MGI:3687963
hm3
Allelic
Composition		 Stat5atm1Mam/Stat5atm1Mam
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Mam mutation (3 available); any Stat5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal prostate gland epithelium morphology ( J:63495 )
• prostate is characterized by an increased prevalence of local disorganization within acinar epithelium of ventral prostates
• affected acini are filled with desquamated, granular epithelial cells that become embedded in dense, coagulated secretory material, resulting in glandular cyst formation
prostate gland cyst ( J:63495 )
• on average, 10.6% show cystic prostates compared to 1% in wild-type, however do not show changes in prostate size or epithelial hyperplasia
abnormal prostate gland physiology ( J:63495 )
• exhibit an increase in prostate secretion of probasin

reproductive system
abnormal prostate gland epithelium morphology ( J:63495 )
• prostate is characterized by an increased prevalence of local disorganization within acinar epithelium of ventral prostates
• affected acini are filled with desquamated, granular epithelial cells that become embedded in dense, coagulated secretory material, resulting in glandular cyst formation
prostate gland cyst ( J:63495 )
• on average, 10.6% show cystic prostates compared to 1% in wild-type, however do not show changes in prostate size or epithelial hyperplasia
abnormal prostate gland physiology ( J:63495 )
• exhibit an increase in prostate secretion of probasin

growth/size/body
prostate gland cyst ( J:63495 )
• on average, 10.6% show cystic prostates compared to 1% in wild-type, however do not show changes in prostate size or epithelial hyperplasia




Genotype
MGI:3688422
hm4
Allelic
Composition		 Stat5atm1Mam/Stat5atm1Mam
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Mam mutation (3 available); any Stat5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:112035 )
• the percentage of NK cells is diminished (about 70% of the percentage seen in wild-type) although to a lesser extent than in Stat5btm1Hwd homozygotes
decreased splenocyte number ( J:112035 )
• exhibit decreased numbers of splenocytes
impaired natural killer cell mediated cytotoxicity ( J:112035 )
• NK cytolytic activity is impaired but to a lesser extent than seen in Stat5btm1Hwd homozygotes

hematopoietic system
decreased NK cell number ( J:112035 )
• the percentage of NK cells is diminished (about 70% of the percentage seen in wild-type) although to a lesser extent than in Stat5btm1Hwd homozygotes
decreased splenocyte number ( J:112035 )
• exhibit decreased numbers of splenocytes
impaired natural killer cell mediated cytotoxicity ( J:112035 )
• NK cytolytic activity is impaired but to a lesser extent than seen in Stat5btm1Hwd homozygotes




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11/12/2024
MGI 6.24 		The Jackson Laboratory