All Phenotypes Tap1<tm1Arp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tap1^tm1Arp
targeted mutation 1, Philip Ashton-Rickardt
MGI:1857253

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tap1^tm1Arp/Tap1^tm1Arp	B6.129S2-Tap1^tm1Arp/J	MGI:3722073
hm2	Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas	MGI:3694695
hm3	Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas * C57BL/6	MGI:3621930
cx4	Erap1^tm1Nsha/Erap1^tm1Nsha Tap1^tm1Arp/Tap1^tm1Arp	B6.129-Erap1^tm1Nsha Tap1^tm1Arp	MGI:3706235
cx5	Tap1^tm1Arp/Tap1^tm1Arp X/Yaa	BXSB.129S2(B6)-Tap1^tm1Arp/Dcr	MGI:6094248
cx6	Col1a1^{tm1(tetO-Yod1)Hpl}/Col1a1^{tm1(tetO-Yod1)Hpl} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:5478623
cx7	Erap1^tm1Nsha/Erap1^tm1Nsha Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2	MGI:3706311
cx8	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas * C57BL/6	MGI:3814823

Allelic Composition	Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	B6.129S2-Tap1^tm1Arp/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), 70% of mice survive a low dose but all mice succumb to a high dose

immune system

increased T-helper 1 cell number ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:123934 )

• following infection with a low dose of IEO, CD8+ T cells in the spleen are reduced (1.2%+/-0.2% of splenocytes compared to 8.0%+/-0.4% of splenocytes in wild-type mice)

decreased susceptibility to bacterial infection ( J:123934 )

• mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice

• at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), 70% of mice survive a low dose but all mice succumb to a high dose

hematopoietic system

increased T-helper 1 cell number ( J:123934 )

decreased CD8-positive, alpha-beta T cell number ( J:123934 )

• following infection with a low dose of IEO, CD8+ T cells in the spleen are reduced (1.2%+/-0.2% of splenocytes compared to 8.0%+/-0.4% of splenocytes in wild-type mice)

Allelic Composition	Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:64177 , J:64349 )

• mice have very few mature CD8+ T cells (J:64177)

• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)

decreased cytotoxic T cell cytolysis ( J:64349 )

• mutants show a strong CTL response to syngeneic antigens from wild-type

abnormal dendritic cell antigen presentation ( J:64349 )

• CD8+ T cell responses to virus and protein antigen are reduced due to inability of dendritic cells to efficiently present antigen

• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma

abnormal antigen presentation via MHC class I ( J:64349 )

• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma

decreased level of surface class I molecules ( J:64177 , J:64349 )

• expression is only ~5% of wild-type (J:64177)

• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)

defective assembly of class I molecules ( J:64177 )

• most MHC class I molecules lack high-affinity peptides

defective intracellular transport of class I molecules ( J:64177 )

• MHC class I heterodimers lacking high-affinity peptides are retained in the endoplasmic reticulum and targeted for degradation in the cytosol

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:64177 , J:64349 )

• mice have very few mature CD8+ T cells (J:64177)

• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)

decreased cytotoxic T cell cytolysis ( J:64349 )

• mutants show a strong CTL response to syngeneic antigens from wild-type

Allelic Composition	Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-negative T cell number ( J:3524 )

• exhibit a 30-40 fold reduction in CD4-CD8- T cells in spleen, blood and lymph nodes, but not thymus

absent CD8-positive, alpha-beta T cells ( J:3524 )

abnormal lymphocyte physiology ( J:122479 )

• class I heavy chains in spleen lymphoblasts are defective in acquisition of EndoH resistance suggesting a defect in class I maturation

abnormal antigen presentation ( J:122479 )

• when ovalbumin is introduced by osmotic shock, mutant cells show impairment in presentation of OVA-derived epitopes

abnormal dendritic cell antigen presentation ( J:112436 )

• mutant bone marrow-derived dendritic cells (BM-DC) treated with ovalbumin-immune complexes (OVA-IC) do not present the MHC class I-restricted epitope after OVA-IC internalization

decreased level of surface class I molecules ( J:3524 )

• splenocytes exhibit little or no H2-Kb or -Db surface expression, however, at lower temperatures (26C) surface expression is increased

defective intracellular transport of class I molecules ( J:3524 )

• class I Kb and Db molecules have little heavy chain sialylation indicating an impaired delivery to trans Golgi

hematopoietic system

decreased double-negative T cell number ( J:3524 )

• exhibit a 30-40 fold reduction in CD4-CD8- T cells in spleen, blood and lymph nodes, but not thymus

absent CD8-positive, alpha-beta T cells ( J:3524 )

abnormal lymphocyte physiology ( J:122479 )

• class I heavy chains in spleen lymphoblasts are defective in acquisition of EndoH resistance suggesting a defect in class I maturation

Allelic Composition	Erap1^tm1Nsha/Erap1^tm1Nsha Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	B6.129-Erap1^tm1Nsha Tap1^tm1Arp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erap1^tm1Nsha mutation (0 available); any Erap1 mutation (59 available)
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal antigen presentation via MHC class I ( J:112389 )

• processing of certain antigenic precursors in the ER is defective in mutant splenocytes, because Arts functions as a unique protease

Allelic Composition	Tap1^tm1Arp/Tap1^tm1Arp X/Yaa
Genetic Background	BXSB.129S2(B6)-Tap1^tm1Arp/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of Tap1 intensifies the severity to a mean survival of only 23 weeks of ag

Allelic Composition	Col1a1^{tm1(tetO-Yod1)Hpl}/Col1a1^{tm1(tetO-Yod1)Hpl} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor^{tm1(rtTAM2)Jae} Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(tetO-Yod1*)Hpl} mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal professional antigen presenting cell physiology ( J:194608 )

• APCs from doxycycline-treated mice exhibit enhanced antigen cross-presentation compared with control cells

Allelic Composition	Erap1^tm1Nsha/Erap1^tm1Nsha Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal antigen presentation via MHC class I ( J:116606 )

• BEko cells in wild-type mice are not activated by APCs (antigen expressing cells) from double mutants, compared to activation elicited by Arts1-single null APCs; response is similar to response of wild-type BEkos to Tap1-deficient APCs

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (35 available)
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

immune system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

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