Phenotypes associated with this allele

• Allele Symbol: Tal1^tm1Sho
• Allele Name: targeted mutation 1, Stuart Orkin
• Allele ID: MGI:1857254
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tal1^tm1Sho/Tal1^tm1Sho	involves: 129S4/SvJae	MGI:2174752

Genotype
MGI:2174752

hm1

• Allelic Composition: Tal1^tm1Sho/Tal1^tm1Sho
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:23061 )

• homozygotes are obtained at the expected Mendelian frequency at E8.5 but die by E10.5

embryo

abnormal placental labyrinth vasculature morphology ( J:23061 )

• at E9.5, homozygotes show absence of embryonic (nucleated) blood cells within endothelial-lined capillaries in the fetal labyrinth

embryonic growth retardation ( J:23061 )

• at E9.5-E10, homozygotes exhibit a delay in overall growth

decreased embryo size ( J:23061 )

• at E9.5-E10, homozygotes are easily distinguished by their smaller size

incomplete somite formation ( J:23061 )

• at E9.5, homozygotes exhibit an average of 21 somite pairs vs >25 pairs found in wild-type embryos

embryo tissue necrosis ( J:23061 )

• at E9.5-E10, homozygotes display extensive necrosis

absent visceral yolk sac blood islands ( J:23061 )

• at E9.5-E10, mutant yolk sacs show absence of nucleated red blood cells

abnormal embryonic hematopoiesis ( J:23061 )

• at E9.5-E10, mutant embryos display total absence of embryonic (nucleated) red cells

hematopoietic system

abnormal embryonic hematopoiesis ( J:23061 )

• at E9.5-E10, mutant embryos display total absence of embryonic (nucleated) red cells

absent common myeloid progenitor cells ( J:23061 )

• in vitro, yolk sac cells obtained from E8.5-E9.0 homozygotes show a virtual absence of myeloid colony formation, suggesting a deficit at the myelo-erythroid progenitor level

anemia ( J:23061 )

• at E9.5-E10, homozygotes are extremely anemic

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:23061 )

• at E9.5, homozygotes show absence of embryonic (nucleated) blood cells within endothelial-lined capillaries in the fetal labyrinth

distended pericardium ( J:23061 )

• at E9.5-E10, homozygotes display dilated pericardial sacs

growth/size/body

embryonic growth retardation ( J:23061 )

• at E9.5-E10, homozygotes exhibit a delay in overall growth

decreased embryo size ( J:23061 )

• at E9.5-E10, homozygotes are easily distinguished by their smaller size

integument

pallor ( J:23061 )

• at E9.5-E10, homozygotes are extremely pale