All Phenotypes Tnfrsf1a<tm1Mak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfrsf1a^tm1Mak
targeted mutation 1, Tak Mak
MGI:1857261

Summary

27 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas	MGI:3706991
hm2	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6J * DBA/2J	MGI:3053442
hm3	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6J * NOD	MGI:3622767
ht4	Tnfrsf1a^tm1Mak/Tnfrsf1a⁺	involves: 129S2/SvPas	MGI:5573130
cn5	Map3k7^tm1Aki/Map3k7^tm1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6	MGI:5464102
cn6	Tab2^tm2.1Aki/Tab2^tm2.1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5464104
cn7	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5582487
cn8	Chuk^tm1Yhu/Chuk^tm1Yhu Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT5-cre)5132Jlj/0	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3817624
cn9	Rela^tm1.2Gho/Rela^tm1.2Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	MGI:3794992
cn10	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3690542
cn11	Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2	MGI:7256612
cn12	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:5582492
cn13	Tnfaip3^tm1.1Gvl/Tnfaip3^tm1.1Gvl Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Vil1-cre)997Gum/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4829677
cx14	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst}	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5305973
cx15	Tbk1^tm1Yeh/Tbk1^tm1Yeh Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129P2/OlaHsd * C57BL/6J	MGI:3050533
cx16	Ikbkb^tm1Ver/Ikbkb^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J	MGI:3609627
cx17	Rela^tm2.1Gho/Rela^tm2.1Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:5574110
cx18	Rela^tm1.1Gho/Rela^tm1.1Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	MGI:3794990
cx19	Tnf^em5Boui/Tnf⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a⁺	involves: 129S2/SvPas * C57BL/6	MGI:6730103
cx20	Tnf^Bpsm1/Tnf^Bpsm1 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:6272039
cx21	Tnf^Bpsm1/Tnf⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:6272040
cx22	Fas^tm1Cgn/Fas^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3690543
cx23	Tg(KRT5-Nfkbia*)3Rto/0 Tg(Krt5-Tnfr1)#Rsab/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5582489
cx24	Tg(CAG-Lyn*)#Paau/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:5512885
cx25	Tg(INS-Il10)#Sar/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6J * NOD	MGI:3622768
cx26	Chuk^tm1Ver/Chuk^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129/Sv * 129S4/SvJae * C57BL/6J	MGI:3609632
cx27	Chuk^tm1Ver/Chuk^tm1Ver Ikbkb^tm1Ver/Ikbkb^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129/Sv * 129S4/SvJae * C57BL/6J	MGI:3609629

Allelic Composition	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:4753 , J:139030 , J:210950 )

• homozygotes succumb to infection following challenge with L. monocytogenes (J:4753)

• in contrast to wildtype, homozygotes exhibit very high titers of Listeria in spleen and liver by day 6 post-infection (J:4753)

• increased susceptibility to L. monocytogenes-induced lethality with 100% lethality even when infected with a low titer of bacteria (J:139030)

• all mice infected with Listeria monocytogenes die unlike wild-type mice (J:210950)

decreased susceptibility to induced morbidity/mortality ( J:210950 )

• no mice treated with TNF die unlike wild-type mice

immune system

abnormal spleen germinal center morphology ( J:139030 )

• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells

decreased IgG level ( J:139030 )

• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls

decreased circulating interleukin-6 level ( J:138824 )

• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection

increased circulating tumor necrosis factor level ( J:139030 )

• in response to LPS stimulation, compared to controls

impaired humoral immune response ( J:210950 )

• mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice

decreased susceptibility to bacterial infection ( J:4753 , J:121930 )

• homozygotes are resistant to high dose (100 ug) bacterial LPS challenge and lethal doses of staphylococcal enterotoxin B (J:4753)

increased susceptibility to bacterial infection induced morbidity/mortality ( J:4753 , J:139030 , J:210950 )

• homozygotes succumb to infection following challenge with L. monocytogenes (J:4753)

• in contrast to wildtype, homozygotes exhibit very high titers of Listeria in spleen and liver by day 6 post-infection (J:4753)

• increased susceptibility to L. monocytogenes-induced lethality with 100% lethality even when infected with a low titer of bacteria (J:139030)

• all mice infected with Listeria monocytogenes die unlike wild-type mice (J:210950)

hematopoietic system

abnormal spleen germinal center morphology ( J:139030 )

• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells

decreased IgG level ( J:139030 )

• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:138824 )

• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection

increased circulating tumor necrosis factor level ( J:139030 )

• in response to LPS stimulation, compared to controls

impaired skin barrier function ( J:59056 )

• slower recovery after superficial injury causes increased trans-epidermal water loss

abnormal response/metabolism to endogenous compounds ( J:210950 )

• TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice

skeleton

increased bone mineral density ( J:135519 )

• significantly increased

integument

impaired skin barrier function ( J:59056 )

• slower recovery after superficial injury causes increased trans-epidermal water loss

cellular

increased sensitivity to induced cell death ( J:210950 )

• in mouse embryonic fibroblasts exposed to hypoxia

Allelic Composition	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

granulomatous inflammation ( J:55889 )

• in response to infection with Mycobacterium avium, mice developed extensive tissue necrosis in all infected tissues and persistent granulomatous lesions which went through acute disintegration before death

• mice depleted of either CD4+ or CD8+ cells after granuloma initiation stayed healthy to day 38 postinfection, with no signs of granuloma destruction

Allelic Composition	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:64051 )

• deficient mice do not develop diabetes over a 24-week period

Allelic Composition	Tnfrsf1a^tm1Mak/Tnfrsf1a⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:210950 )

• no mice treated with TNF die unlike all wild-type mice

immune system

decreased circulating interleukin-6 level ( J:210950 )

• decreased induction in TNF-treated mice

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:210950 )

• decreased induction in TNF-treated mice

abnormal response/metabolism to endogenous compounds ( J:210950 )

• TNF-treated mice fail to exhibit lethality, as great IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (52 available)
Tg(Tek-cre)12Flv mutation (1 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191285 )

• mice die by E13.5

cardiovascular system

cardiovascular system phenotype ( J:191285 )

N	• blood vessels do not exhibit regression and exhibit normal vessel length and branching

dilated vasculature ( J:191285 )

cellular

cellular phenotype ( J:191285 )

N	• embryonic endothelial cell apoptosis is rescued

Allelic Composition	Tab2^tm2.1Aki/Tab2^tm2.1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab2^tm2.1Aki mutation (0 available); any Tab2 mutation (31 available)
Tg(Tek-cre)12Flv mutation (1 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191285 )

• mice die by E14.5

cardiovascular system

abnormal vascular development ( J:191285 )

• as in Tab2^tm2.1Aki/Tab2^tm2.1Aki Tg(Tek-cre)12Flv mice

Allelic Composition	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:208995 )

N	• mice reach adulthood without showing inflammatory skin lesions

Allelic Composition	Chuk^tm1Yhu/Chuk^tm1Yhu Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Yhu mutation (0 available); any Chuk mutation (49 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:141162 )

• mice die slightly earlier than Chuk^tm1Yhu/Chuk^tm1Yhu Tg(KRT5-cre)1Jlj mice

integument

epidermal hyperplasia ( J:141162 )

• as in Chuk^tm1Yhu/Chuk^tm1Yhu Tg(KRT5-cre)1Jlj mice

thick epidermis ( J:141162 )

• as in Chuk^tm1Yhu/Chuk^tm1Yhu Tg(KRT5-cre)1Jlj mice

Allelic Composition	Rela^tm1.2Gho/Rela^tm1.2Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rela^tm1.2Gho mutation (0 available); any Rela mutation (26 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:134684 )

• double homozygous mice die before 40 days

• the embryonic lethality seen among Rela^tm1.2Gho is completely rescued

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (82 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:114741 )

N	• B and T cell distribution in the lymph nodes is normal • the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• mice are almost completely resistant to induction of experimental autoimmune encephalomyelitis (EAE) by injection of MOG p35-55

• almost no oligodendrocyte apoptosis after EAE induction unlike in wild-type mice

• reduction in demyelination and inflammation after induction of EAE is greater than in mutant mice wild-type for Tnfrsf1a

• 24 days after induction of EAE, minimal axonal injury is seen in spinal cords

Allelic Composition	Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulin^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Otulin mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:312394 )

N	• normal circulating inflammatory cytokine and chemokine levels

integument

integument phenotype ( J:312394 )

N	• no dermatitis and normal epidermal thickness up to age older than 40 weeks

Allelic Composition	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:208995 )

N	• mice reach adulthood without showing inflammatory skin lesions

Allelic Composition	Tnfaip3^tm1.1Gvl/Tnfaip3^tm1.1Gvl Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfaip3^tm1.1Gvl mutation (0 available); any Tnfaip3 mutation (43 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased susceptibility to induced colitis ( J:163410 )

• mice exhibit decreased susceptibility compared to Tnfrsf1a^tm1Mak/Tnfrf1⁺ Tnfaip3^tm1.1Gvl Tg(Vil-cre)997Gum mice

increased susceptibility to induced colitis ( J:163410 )

• mice exhibit increased susceptibility compared to in Tnfrsf1a^tm1Mak homozygotes

immune system

decreased susceptibility to induced colitis ( J:163410 )

• mice exhibit decreased susceptibility compared to Tnfrsf1a^tm1Mak/Tnfrf1⁺ Tnfaip3^tm1.1Gvl Tg(Vil-cre)997Gum mice

increased susceptibility to induced colitis ( J:163410 )

• mice exhibit increased susceptibility compared to in Tnfrsf1a^tm1Mak homozygotes

Allelic Composition	Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst}
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)
Tnip1^{Gt(E059E05)Wrst} mutation (0 available); any Tnip1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:180054 )

• mice die within 6 months of birth

prenatal lethality, incomplete penetrance ( J:180054 )

• slightly fewer than expected mice are born alive

immune system

spleen hyperplasia ( J:180054 )

increased neutrophil cell number ( J:180054 )

increased susceptibility to systemic lupus erythematosus ( J:180054 )

• mice develop similar inflammatory disease (body weight loss, anemia, neutrophilia, leukocyte organ infiltrations, and glomerulonephritis) as observed in Tnip1^{Gt(E059E05)Wrst} homozygotes

glomerulonephritis ( J:180054 )

hematopoietic system

spleen hyperplasia ( J:180054 )

anemia ( J:180054 )

decreased hemoglobin content ( J:180054 )

increased neutrophil cell number ( J:180054 )

growth/size/body

decreased body weight ( J:180054 )

spleen hyperplasia ( J:180054 )

renal/urinary system

glomerulonephritis ( J:180054 )

Allelic Composition	Tbk1^tm1Yeh/Tbk1^tm1Yeh Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1^tm1Yeh mutation (1 available); any Tbk1 mutation (55 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:91653 )

N	• double homozygotes develop to term unlike Tbk1^tm1Yeh homozygotes that die at around E14.5

Allelic Composition	Ikbkb^tm1Ver/Ikbkb^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm1Ver mutation (0 available); any Ikbkb mutation (54 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:54323 )

• double homozygotes develop to term but die within the first postnatal month, unlike Ikbkb^tm1Ver mutant embryos that die at ~E12.5-E13.5

Allelic Composition	Rela^tm2.1Gho/Rela^tm2.1Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rela^tm2.1Gho mutation (0 available); any Rela mutation (26 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:163663 )

• 50%-60% die sometime between 1 and 6 months of age

vision/eye

cornea vascularization ( J:163663 )

• vascularized and proliferative corneal lesion developed in the central region of the cornea

increased incidence of corneal inflammation ( J:163663 )

• neutrophils and macrophages

abnormal cornea epithelium morphology ( J:163663 )

• occasional dying keratinocytes are present

increased cornea epithelium thickness ( J:163663 )

• severe corneal epithelial thickening is observed, occurring abruptly at the junction of the central and peripheral

decreased cornea thickness ( J:163663 )

• at 25 days, the corneal epithelium is slightly thinner and keratinocytes are less orderly

liver/biliary system

liver inflammation ( J:163663 )

• slowly progressive hepatic inflammation

• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils

liver fibrosis ( J:163663 )

• capsular fibrosis and inflammation is also seen

cardiovascular system

cornea vascularization ( J:163663 )

• vascularized and proliferative corneal lesion developed in the central region of the cornea

immune system

increased incidence of corneal inflammation ( J:163663 )

• neutrophils and macrophages

liver inflammation ( J:163663 )

• slowly progressive hepatic inflammation

• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils

Allelic Composition	Rela^tm1.1Gho/Rela^tm1.1Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rela^tm1.1Gho mutation (0 available); any Rela mutation (26 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:134684 )

• a few mice survived to birth died about 1 month after birth

prenatal lethality, incomplete penetrance ( J:134684 )

• most homozygous mice died in utero before birth

• very small number of mutant mice survived to birth

vision/eye

abnormal eye development ( J:134684 )

• a few mice survived to birth show eye developmental defect and were blind

blindness ( J:134684 )

• a few mice survived to birth show eye developmental defect and were blind

Allelic Composition	Tnf^em5Boui/Tnf⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnf^em5Boui mutation (0 available); any Tnf mutation (46 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovalvulitis ( J:306876 )

digestive/alimentary system

colitis ( J:306876 )

• inflammatory bowel disease (IBD) in gut in surviving mice at age P20

immune system

cardiovalvulitis ( J:306876 )

colitis ( J:306876 )

• inflammatory bowel disease (IBD) in gut in surviving mice at age P20

arthritis ( J:306876 )

• deformed ankles and wrists in surviving mice from age P7

• large pannus tissue invasion in synovial joints in surviving mice at age P20

mortality/aging

premature death ( J:306876 )

• surviving mice die by age 33 days

preweaning lethality, incomplete penetrance ( J:306876 )

• 80% of embryos die within hours of birth

respiratory system

abnormal lung morphology ( J:306876 )

• failure to initiate respiration: underinflated lungs in pups that died within hours of birth

skeleton

arthritis ( J:306876 )

• deformed ankles and wrists in surviving mice from age P7

• large pannus tissue invasion in synovial joints in surviving mice at age P20

Allelic Composition	Tnf^Bpsm1/Tnf^Bpsm1 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnf^Bpsm1 mutation (0 available); any Tnf mutation (46 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:226052 )

immune system

increased circulating tumor necrosis factor level ( J:226052 )

skeleton

skeleton phenotype ( J:226052 )

N	• mice do not develop rheumatoid arthritis

Allelic Composition	Tnf^Bpsm1/Tnf⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:226052 )

immune system

increased circulating tumor necrosis factor level ( J:226052 )

skeleton

skeleton phenotype ( J:226052 )

N	• mice do not develop rheumatoid arthritis

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (82 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• reduction in the onset and severity, but not incidence of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55

• about a 75% reduction in oligodendrocyte apoptosis after EAE induction compared to wild-type mice

• inflammation after EAE induction is also reduced

Allelic Composition	Tg(KRT5-Nfkbia*)3Rto/0 Tg(Krt5-Tnfr1)#Rsab/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-Nfkbia*)3Rto mutation (0 available)
Tg(Krt5-Tnfr1)#Rsab mutation (0 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:208995 )

• in most mice within 10 days

integument

skin inflammation ( J:208995 )

• within the first 3 to 4 days after birth

epidermal hyperplasia ( J:208995 )

• within the first 3 to 4 days after birth

immune system

skin inflammation ( J:208995 )

• within the first 3 to 4 days after birth

Allelic Composition	Tg(CAG-Lyn*)#Paau/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Lyn*)#Paau mutation (0 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:151886 )

N	• mice exhibit normal skin architecture and all mice reach adulthood

Allelic Composition	Tg(INS-Il10)#Sar/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:64051 )

• 60% of deficient transgenic mice develop diabetes by 5 weeks (blood glucose measuring >300 mg/dl), while 100% develop diabetes by 10 weeks compared to 0% of nontransgenic littermates

homeostasis/metabolism

increased circulating glucose level ( J:64051 )

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Allelic Composition	Chuk^tm1Ver/Chuk^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Ver mutation (0 available); any Chuk mutation (49 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

broad limb buds ( J:63443 )

• at E14.5, double homozygotes exhibit dumpy limb buds, similar to those observed in Chuk^tm1Ver mutant embryos

curly tail ( J:63443 )

• at E14.5, double homozygotes exhibit curled tails, similar to those observed in Chuk^tm1Ver mutant embryos

embryo

broad limb buds ( J:63443 )

• at E14.5, double homozygotes exhibit dumpy limb buds, similar to those observed in Chuk^tm1Ver mutant embryos

Allelic Composition	Chuk^tm1Ver/Chuk^tm1Ver Ikbkb^tm1Ver/Ikbkb^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Ver mutation (0 available); any Chuk mutation (49 available)
Ikbkb^tm1Ver mutation (0 available); any Ikbkb mutation (54 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:63443 )

• triple homozygotes survive to ~E16.5, exhibiting a morphology similar to that observed in Chuk^tm1Ver mutant embryos

limbs/digits/tail

broad limb buds ( J:63443 )

• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuk^tm1Ver mutant embryos

curly tail ( J:63443 )

• at E14.5, triple homozygotes exhibit curled tails, similar to those observed in Chuk^tm1Ver mutant embryos

nervous system

open neural tube ( J:63443 )

• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuk^tm1Ver and Ikbkb^tm1Ver

embryo

broad limb buds ( J:63443 )

• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuk^tm1Ver mutant embryos

open neural tube ( J:63443 )

• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuk^tm1Ver and Ikbkb^tm1Ver

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