All Phenotypes Tnfrsf1b<tm1Mwm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfrsf1b^tm1Mwm
targeted mutation 1, Mark Moore
MGI:1857262

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	B6.129S2-Tnfrsf1b^tm1Mwm	MGI:3622069
hm2	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	B6.129S2-Tnfrsf1b^tm1Mwm/J	MGI:3580520
hm3	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6	MGI:4354646
hm4	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6J	MGI:3620002
hm5	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6J * NOD	MGI:3622765
cx6	Ifng^tm1Ts/Ifng^tm1Ts Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:4843969
cx7	Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4838237
cx8	Tg(Tnf)6074Gkl/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:4461139
cx9	Krt8^tm1Rgo/Krt8^tm1Rgo Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:3711995
cx10	Tg(INS-Il10)#Sar/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6J * NOD	MGI:3622772
cx11	Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3622064
cx12	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129/Sv * C57BL/6	MGI:3053739

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	B6.129S2-Tnfrsf1b^tm1Mwm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired central nervous system regeneration ( J:71178 )

• 7 days after traumatic spinal cord injury increased cell death is seen in the center of the lesion and the rostrocaudal spread of the lesion is increased compared to wild-type

• 4 weeks after traumatic spinal cord injury locomotor performance is significantly more impaired but lesions are not significantly longer than in wild-type mice

behavior/neurological

abnormal sleep pattern ( J:103266 )

• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice

• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice

• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	B6.129S2-Tnfrsf1b^tm1Mwm/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

immune system

immune system phenotype ( J:288523 )

N	• mice infected with mouse-adapted SARS-CoV MA15 exhibit a modest but non-significant weight loss indicating similar susceptibility to infection as wild-type mice

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

decreased interferon-gamma secretion ( J:107039 )

• CD8+ T cells produce less interferon gamma following anti-CD3 stimulation than control cells; the result of fewer cells expressing interferon gamma as well as a decrease in the amount produced per cell

decreased interleukin-2 secretion ( J:107039 )

• CD8+ T cells exhibit a reduction in IL2 secretion following anti-CD3 stimulation

hematopoietic system

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG

decreased susceptibility to bacterial infection ( J:50903 )

• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice

increased susceptibility to parasitic infection ( J:114203 )

• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice

• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system physiology ( J:21815 )

• decreased sensitivity to exogenous tumor necrosis factor (TNF), however, death occurs at high doses

increased susceptibility to bacterial infection ( J:21815 )

• increased mortality as compared to wild-type following injection with Listeria monocytogenes

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

periinsulitis ( J:64051 )

• at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis

decreased susceptibility to autoimmune diabetes ( J:64051 )

• none of the animals develop diabetes until 24 weeks (no blood glucose measure of >300 mg/dl)

endocrine/exocrine glands

periinsulitis ( J:64051 )

• at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis

Allelic Composition	Ifng^tm1Ts/Ifng^tm1Ts Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifng^tm1Ts mutation (18 available); any Ifng mutation (49 available)
Tnfrsf1a^tm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased leukocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased eosinophil cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased lymphocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

small Peyer's patches ( J:119206 )

• grossly unidentifiable and histologically hypoplastic

abnormal lymph node cortex morphology ( J:119206 )

• thin and lack primary and secondary cortical follicles

abnormal lymph node primary follicle morphology ( J:119206 )

• absent

abnormal lymph node secondary follicle morphology ( J:119206 )

• absent

absent lymph node germinal center ( J:119206 )

lung inflammation ( J:119206 )

• develop severe inflammation 4 weeks after infection with Pneumocystis carinii

increased susceptibility to fungal infection ( J:119206 )

• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection

• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice

hematopoietic system

increased leukocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased eosinophil cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased lymphocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

respiratory system

lung inflammation ( J:119206 )

• develop severe inflammation 4 weeks after infection with Pneumocystis carinii

Allelic Composition	Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:119206 )

N	• mice are able to clear infections of Pneumocystis carinii similar to controls

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

decreased IgG1 level ( J:115225 )

• following treatment with MOG

small Peyer's patches ( J:119206 )

• grossly unidentifiable and histologically hypoplastic

abnormal lymph node cortex morphology ( J:119206 )

• thin and lack primary and secondary cortical follicles

abnormal lymph node primary follicle morphology ( J:119206 )

• absent

abnormal lymph node secondary follicle morphology ( J:119206 )

• absent

absent lymph node germinal center ( J:119206 )

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice

increased susceptibility to parasitic infection ( J:114203 )

• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice

• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

hematopoietic system

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

decreased IgG1 level ( J:115225 )

• following treatment with MOG

Allelic Composition	Tg(Tnf)6074Gkl/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnf)6074Gkl mutation (1 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal oligodendrocyte apoptosis ( J:106592 )

• in 4 week old mice

CNS inflammation ( J:106592 )

• in 4 week old mice

demyelination ( J:106592 )

• cerebellum myelin vacuolation in 4 week old mice

immune system

CNS inflammation ( J:106592 )

• in 4 week old mice

cellular

abnormal oligodendrocyte apoptosis ( J:106592 )

• in 4 week old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592

Allelic Composition	Krt8^tm1Rgo/Krt8^tm1Rgo Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt8^tm1Rgo mutation (1 available); any Krt8 mutation (34 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:121811 )

• survival improved 4 fold in the absence of maternal TNFRSF1b as compared to the condition in which TNFRSF1b was present

• survival continues to be reduced

Allelic Composition	Tg(INS-Il10)#Sar/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:64051 )

• 100% of deficient transgenic animals develop diabetes by 5 weeks (blood glucose >300 mg/dl), while only 60% of non-transgenic littermates develop diabetes by 24 weeks

homeostasis/metabolism

increased circulating glucose level ( J:64051 )

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Allelic Composition	Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)
Tnf^tm2Gkl mutation (1 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small intestinal inflammation ( J:54056 )

• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnf^tm2Gkl only

rheumatoid arthritis ( J:54056 )

• arthritis is more aggressive and destructive than in mice heterozygous for Tnf^tm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage

digestive/alimentary system

small intestinal inflammation ( J:54056 )

• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnf^tm2Gkl only

skeleton

rheumatoid arthritis ( J:54056 )

Allelic Composition	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen

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