All Phenotypes Tnfrsf1b<tm1Mwm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfrsf1b^tm1Mwm
targeted mutation 1, Mark Moore
MGI:1857262

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	B6.129S2-Tnfrsf1b^tm1Mwm	MGI:3622069
hm2	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	B6.129S2-Tnfrsf1b^tm1Mwm/J	MGI:3580520
hm3	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6	MGI:4354646
hm4	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6J	MGI:3620002
hm5	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6J * NOD	MGI:3622765
cx6	Ifng^tm1Ts/Ifng^tm1Ts Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:4843969
cx7	Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4838237
cx8	Tg(Tnf)6074Gkl/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:4461139
cx9	Krt8^tm1Rgo/Krt8^tm1Rgo Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:3711995
cx10	Tg(INS-Il10)#Sar/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S2/SvPas * C57BL/6J * NOD	MGI:3622772
cx11	Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3622064
cx12	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129/Sv * C57BL/6	MGI:3053739

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	B6.129S2-Tnfrsf1b^tm1Mwm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired central nervous system regeneration ( J:71178 )

• 7 days after traumatic spinal cord injury increased cell death is seen in the center of the lesion and the rostrocaudal spread of the lesion is increased compared to wild-type

• 4 weeks after traumatic spinal cord injury locomotor performance is significantly more impaired but lesions are not significantly longer than in wild-type mice

behavior/neurological

abnormal sleep pattern ( J:103266 )

• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice

• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice

• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	B6.129S2-Tnfrsf1b^tm1Mwm/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

immune system

immune system phenotype ( J:288523 )

N	• mice infected with mouse-adapted SARS-CoV MA15 exhibit a modest but non-significant weight loss indicating similar susceptibility to infection as wild-type mice

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

decreased interferon-gamma secretion ( J:107039 )

• CD8+ T cells produce less interferon gamma following anti-CD3 stimulation than control cells; the result of fewer cells expressing interferon gamma as well as a decrease in the amount produced per cell

decreased interleukin-2 secretion ( J:107039 )

• CD8+ T cells exhibit a reduction in IL2 secretion following anti-CD3 stimulation

hematopoietic system

decreased T cell proliferation ( J:107039 )

• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type

• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2

• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG

decreased susceptibility to bacterial infection ( J:50903 )

• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice

increased susceptibility to parasitic infection ( J:114203 )

• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice

• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system physiology ( J:21815 )

• decreased sensitivity to exogenous tumor necrosis factor (TNF), however, death occurs at high doses

increased susceptibility to bacterial infection ( J:21815 )

• increased mortality as compared to wild-type following injection with Listeria monocytogenes

Allelic Composition	Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

periinsulitis ( J:64051 )

• at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis

decreased susceptibility to autoimmune diabetes ( J:64051 )

• none of the animals develop diabetes until 24 weeks (no blood glucose measure of >300 mg/dl)

endocrine/exocrine glands

periinsulitis ( J:64051 )

• at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis

Allelic Composition	Ifng^tm1Ts/Ifng^tm1Ts Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifng^tm1Ts mutation (18 available); any Ifng mutation (47 available)
Tnfrsf1a^tm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased leukocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased eosinophil cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased lymphocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

small Peyer's patches ( J:119206 )

• grossly unidentifiable and histologically hypoplastic

abnormal lymph node cortex morphology ( J:119206 )

• thin and lack primary and secondary cortical follicles

abnormal lymph node primary follicle morphology ( J:119206 )

• absent

abnormal lymph node secondary follicle morphology ( J:119206 )

• absent

absent lymph node germinal center ( J:119206 )

lung inflammation ( J:119206 )

• develop severe inflammation 4 weeks after infection with Pneumocystis carinii

increased susceptibility to fungal infection ( J:119206 )

• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection

• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice

hematopoietic system

increased leukocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased eosinophil cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

increased lymphocyte cell number ( J:119206 )

• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

respiratory system

lung inflammation ( J:119206 )

• develop severe inflammation 4 weeks after infection with Pneumocystis carinii

Allelic Composition	Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:119206 )

N	• mice are able to clear infections of Pneumocystis carinii similar to controls

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

decreased IgG1 level ( J:115225 )

• following treatment with MOG

small Peyer's patches ( J:119206 )

• grossly unidentifiable and histologically hypoplastic

abnormal lymph node cortex morphology ( J:119206 )

• thin and lack primary and secondary cortical follicles

abnormal lymph node primary follicle morphology ( J:119206 )

• absent

abnormal lymph node secondary follicle morphology ( J:119206 )

• absent

absent lymph node germinal center ( J:119206 )

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice

increased susceptibility to parasitic infection ( J:114203 )

• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice

• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

hematopoietic system

absent spleen germinal center ( J:119206 )

• despite the absence of germinal centers the white pulp has distinct T and B cell areas

decreased IgG1 level ( J:115225 )

• following treatment with MOG

Allelic Composition	Tg(Tnf)6074Gkl/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnf)6074Gkl mutation (1 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal oligodendrocyte apoptosis ( J:106592 )

• in 4 week old mice

CNS inflammation ( J:106592 )

• in 4 week old mice

demyelination ( J:106592 )

• cerebellum myelin vacuolation in 4 week old mice

immune system

CNS inflammation ( J:106592 )

• in 4 week old mice

cellular

abnormal oligodendrocyte apoptosis ( J:106592 )

• in 4 week old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592

Allelic Composition	Krt8^tm1Rgo/Krt8^tm1Rgo Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt8^tm1Rgo mutation (1 available); any Krt8 mutation (34 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:121811 )

• survival improved 4 fold in the absence of maternal TNFRSF1b as compared to the condition in which TNFRSF1b was present

• survival continues to be reduced

Allelic Composition	Tg(INS-Il10)#Sar/0 Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:64051 )

• 100% of deficient transgenic animals develop diabetes by 5 weeks (blood glucose >300 mg/dl), while only 60% of non-transgenic littermates develop diabetes by 24 weeks

homeostasis/metabolism

increased circulating glucose level ( J:64051 )

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Allelic Composition	Tnf^tm2Gkl/Tnf⁺ Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)
Tnf^tm2Gkl mutation (1 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small intestinal inflammation ( J:54056 )

• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnf^tm2Gkl only

rheumatoid arthritis ( J:54056 )

• arthritis is more aggressive and destructive than in mice heterozygous for Tnf^tm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage

digestive/alimentary system

small intestinal inflammation ( J:54056 )

• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnf^tm2Gkl only

skeleton

rheumatoid arthritis ( J:54056 )

Allelic Composition	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24