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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Relatm1Bal
targeted mutation 1, David Baltimore
MGI:1857270
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Relatm1Bal/Relatm1Bal B6.129S4-Relatm1Bal MGI:3799115
hm2
 		Relatm1Bal/Relatm1Bal B6;129S4-Relatm1Bal/J MGI:3799217
hm3
 		Relatm1Bal/Relatm1Bal involves: 129S4/SvJae MGI:3799098
hm4
 		Relatm1Bal/Relatm1Bal involves: 129S4/SvJae * C57BL/6J MGI:3799096
cx5
 		Reltm1Grd/Reltm1Grd
Relatm1Bal/Relatm1Bal 		B6.129S-Reltm1Grd Relatm1Bal MGI:3799117
cx6
 		Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo 		involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae MGI:3046863
cx7
 		Reltm1Grd/Reltm1Grd
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo 		involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae MGI:3046865
cx8
 		Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:3799122
cx9
 		Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Rela+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3799208
cx10
 		Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo 		involves: 129S1/Sv * 129S4/SvJae * C57BL/6 MGI:3799163
cx11
 		Bidtm1Sjk/Bidtm1Sjk
Relatm1Bal/Relatm1Bal 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:3796611
cx12
 		Relatm1Bal/Relatm1Bal
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx 		involves: 129S4/SvJae * C57BL/6 MGI:3799195
cx13
 		Relatm1Bal/Relatm1Bal
Tg(SERPINA1-BCL2)1Pva/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:3799177


Genotype
MGI:3799115
hm1
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Genetic
Background		 B6.129S4-Relatm1Bal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:111325 )
• despite normal appearance up to E13, all mice are dead by E15

liver/biliary system
increased hepatocyte apoptosis ( J:111325 )
• most mice exhibit fetal liver cell apoptosis by E14.5

cardiovascular system
internal hemorrhage ( J:111325 )
• most mice exhibit abdominal hemorrhage by E14.5

cellular
increased hepatocyte apoptosis ( J:111325 )
• most mice exhibit fetal liver cell apoptosis by E14.5




Genotype
MGI:3799217
hm2
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Genetic
Background		 B6;129S4-Relatm1Bal/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:91366 )
N
• despite altered expression of Trp53, neurons exhibit normal camptothecin-induced neuronal death




Genotype
MGI:3799098
hm3
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal trigeminal nerve morphology ( J:119844 )
• at E14, the number of neurons in the trigeminal ganglia is decrease compared to in wild-type mice
abnormal neuron physiology ( J:119844 )
• survival following treatment of sensory neurons with NGF is lower than for similarly treated wild-type neurons due to increased apoptosis
• however, sensory neurons exhibit normal survival response to BDNF
increased neuron apoptosis ( J:119844 )
• apoptosis in the trigeminal ganglia of E14 mice is increased compared to in wild-type mice

cellular
abnormal cell death ( J:28390 )
• embryonic fibroblasts treated with mTNF-alpha exhibit decreased survival compared to similarly treated cells
increased neuron apoptosis ( J:119844 )
• apoptosis in the trigeminal ganglia of E14 mice is increased compared to in wild-type mice

immune system
immune system phenotype ( J:113514 )
N
• mice exhibit normal dendritic cell development and maturation
decreased marginal zone B cell number ( J:65246 )
• when cells are used to reconstitute a Rag2 null mouse, the number of marginal zone B cells is reduced to one third of normal

hematopoietic system
decreased marginal zone B cell number ( J:65246 )
• when cells are used to reconstitute a Rag2 null mouse, the number of marginal zone B cells is reduced to one third of normal




Genotype
MGI:3799096
hm4
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:28390 )
• after E14 mice begin to die and none survive to birth

liver/biliary system
increased hepatocyte apoptosis ( J:28390 )
• liver degeneration is associated with increased apoptosis of liver cells
liver degeneration ( J:28390 )
• E15 to E16, mice exhibit liver degeneration that specifically targets hepatocytes leaving hematopoietic precursors and red blood cells intact
• liver degeneration is associated with increased apoptosis of liver cells

cardiovascular system
internal hemorrhage ( J:28390 )
• at E16, surviving mice exhibit massive abdominal hemorrhage

cellular
increased hepatocyte apoptosis ( J:28390 )
• liver degeneration is associated with increased apoptosis of liver cells




Genotype
MGI:3799117
cx5
Allelic
Composition		 Reltm1Grd/Reltm1Grd
Relatm1Bal/Relatm1Bal
Genetic
Background		 B6.129S-Reltm1Grd Relatm1Bal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Reltm1Grd mutation (2 available); any Rel mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111325 )
• despite normal appearance up to E12, all mice are dead by E14

hematopoietic system
hematopoietic system phenotype ( J:111325 )
N
• despite impaired erythropoeisis, hematopoietic development potential is normal
abnormal monocyte differentiation ( J:111325 )
• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
decreased common myeloid progenitor cell number ( J:111325 )
• 2.5-fold compared to in wild-type mice
abnormal erythropoiesis ( J:111325 )
• mice and irradiated wild-type mice transplanted with mutant mice bone marrow exhibit impaired erythropoiesis
increased granulocyte number ( J:111325 )
• irradiated mice reconstituted with mutant bone marrow exhibit granulocytosis of fetal liver cells

liver/biliary system
increased hepatocyte apoptosis ( J:111325 )
• most mice exhibit fetal liver cell apoptosis by E13.5

cardiovascular system
internal hemorrhage ( J:111325 )
• most mice exhibit abdominal hemorrhage by E13.5

immune system
abnormal monocyte differentiation ( J:111325 )
• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
increased granulocyte number ( J:111325 )
• irradiated mice reconstituted with mutant bone marrow exhibit granulocytosis of fetal liver cells

cellular
increased hepatocyte apoptosis ( J:111325 )
• most mice exhibit fetal liver cell apoptosis by E13.5
abnormal monocyte differentiation ( J:111325 )
• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice




Genotype
MGI:3046863
cx6
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Tnftm1Ljo mutation (3 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:91366 )
• triple homozygous pups die within 12 hours of birth
prenatal lethality, incomplete penetrance ( J:91366 )
• fewer than expected triple homozygous mutants are found at birth

integument
thin epidermis ( J:91366 )
• the epidermis is marginally thinner




Genotype
MGI:3046865
cx7
Allelic
Composition		 Reltm1Grd/Reltm1Grd
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Reltm1Grd mutation (2 available); any Rel mutation (45 available)
Tnftm1Ljo mutation (3 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:91366 )
• triple homozygous pups die within 12 hours of birth

cellular
abnormal cell cycle ( J:91366 )
• transit-amplifying epidermal cells display a delay in G1/S phase progression
decreased cell proliferation ( J:91366 )
• transit-amplifying epidermal cells display reduced proliferation

embryo
decreased embryo size ( J:91366 )
• triple homozygous embryos are about 30% smaller compared to littermate controls

growth/size/body
decreased embryo size ( J:91366 )
• triple homozygous embryos are about 30% smaller compared to littermate controls

integument
abnormal hair follicle placode formation ( J:91366 )
• about a 24 hour delay in hair placode formation is seen compared to control littermates
underdeveloped hair follicles ( J:91366 )
• at E18 the hair follicles that are present are only rudimentary buds lacking hair shafts
decreased hair follicle number ( J:91366 )
• at E18, 70% fewer hair follicles are present compared to control littermates
abnormal epidermis stratum basale morphology ( J:91366 )
• the cells in the basal cell layer are organized differently and the basal cell profile area is reduced by about 33%
abnormal keratinocyte morphology ( J:91366 )
• the number of differentiating keratinocytes is reduced
thin epidermis ( J:91366 )
• the epidermis is significantly thinner




Genotype
MGI:3799122
cx8
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal dendritic cell differentiation ( J:113514 )
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
decreased dendritic cell number ( J:113514 )
• in culture, very few dendritic cells differentiate from bone marrow cells

immune system
abnormal dendritic cell differentiation ( J:113514 )
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
decreased dendritic cell number ( J:113514 )
• in culture, very few dendritic cells differentiate from bone marrow cells

cellular
abnormal dendritic cell differentiation ( J:113514 )
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal




Genotype
MGI:3799208
cx9
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Rela+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
diarrhea ( J:67107 )
• severe
abnormal colon morphology ( J:67107 )
• mice exhibit colonic perforations and typhlocolitis
large intestinal inflammation ( J:67107 )
• mice exhibit typhlocolitis

immune system
large intestinal inflammation ( J:67107 )
• mice exhibit typhlocolitis
increased susceptibility to bacterial infection ( J:67107 )
• mice are more sensitive to typhlocolitis induced by H. hepaticus than wild-type mice with a more rapid onset of diarrhea, enlargement and thickening of the colon, thickening of the mucosa characterized by extensive ulcerations, elongated irregularly shaped glands and crypt abscesses, lamina propria fibrosis and infiltration granulation tissue, dilated lymphatics, and multifocal necrotizing vasculitis with thrombosis, and expanded submucosa and serosa with infiltration




Genotype
MGI:3799163
cx10
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Tnftm1Ljo mutation (3 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:124444 )
• Schwann cell apoptosis is increased compared to in wild-type mice 24 hours post-axotomy




Genotype
MGI:3796611
cx11
Allelic
Composition		 Bidtm1Sjk/Bidtm1Sjk
Relatm1Bal/Relatm1Bal
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bidtm1Sjk mutation (1 available); any Bid mutation (44 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:117693 )
• mice die around the same time as Relatm1Bal homozygotes: Bid deletion does not rescue the lethality

liver/biliary system
liver hemorrhage ( J:132334 )
• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos
abnormal liver morphology ( J:132334 )
• at E14.5 and 15.5, embryos show similar level of liver destruction as control Rela-null embryos

cardiovascular system
liver hemorrhage ( J:132334 )
• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos

cellular
decreased fibroblast apoptosis ( J:117693 )
• mouse embryonic fibroblasts are partially protected from TNF-alpha-induced apoptosis compared to exposed Relatm1Bal homozygous mouse embryonic fibroblasts




Genotype
MGI:3799195
cx12
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Tnfrsf1atm1Imx mutation (6 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:60742 )
• mice die between 6 and 17 days after birth
• however, prenatal lethality observed in Relatm1Bal homozygotes is reversed

hematopoietic system
abnormal thymus morphology ( J:60742 )
• at the time of death mice exhibit foci of degeneration in the thymus
extramedullary hematopoiesis ( J:60742 )
• in the liver of 2 to 7 day old mice
abnormal spleen germinal center morphology ( J:60742 )
• at the time of death, mice exhibit less compact germinal centers compared to in wild-type mice
decreased spleen white pulp amount ( J:60742 )
• at the time of death

liver/biliary system
liver inflammation ( J:60742 )
• at the time of death mice, exhibit acute hepatitis with massive neutrophilic infiltration and necrotic foci
focal hepatic necrosis ( J:60742 )
• at the time of death

cardiovascular system
heart inflammation ( J:60742 )
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs

growth/size/body
decreased body size ( J:60742 )
• within the first week after birth, mice become runted despite continued nursing

respiratory system
lung inflammation ( J:60742 )
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs

immune system
heart inflammation ( J:60742 )
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs
abnormal thymus morphology ( J:60742 )
• at the time of death mice exhibit foci of degeneration in the thymus
abnormal spleen germinal center morphology ( J:60742 )
• at the time of death, mice exhibit less compact germinal centers compared to in wild-type mice
decreased spleen white pulp amount ( J:60742 )
• at the time of death
liver inflammation ( J:60742 )
• at the time of death mice, exhibit acute hepatitis with massive neutrophilic infiltration and necrotic foci
lung inflammation ( J:60742 )
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs

endocrine/exocrine glands
abnormal thymus morphology ( J:60742 )
• at the time of death mice exhibit foci of degeneration in the thymus




Genotype
MGI:3799177
cx13
Allelic
Composition		 Relatm1Bal/Relatm1Bal
Tg(SERPINA1-BCL2)1Pva/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
Tg(SERPINA1-BCL2)1Pva mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte apoptosis ( J:126292 )
• over-expression of Bcl-2 transgene fails to prevent hepatocyte apoptosis induced by endogenous TNF-alpha

cellular
increased hepatocyte apoptosis ( J:126292 )
• over-expression of Bcl-2 transgene fails to prevent hepatocyte apoptosis induced by endogenous TNF-alpha




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory