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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptprctm1Holm
targeted mutation 1, Nick Holmes
MGI:1857277
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptprctm1Holm/Ptprctm1Holm involves: 129/Sv * C57BL/6 MGI:3032848
cx2
 		Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)2964Rmp/? 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:3032909
cx3
 		Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)3073Rmp/? 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:3032910


Genotype
MGI:3032848
hm1
Allelic
Composition		 Ptprctm1Holm/Ptprctm1Holm
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprctm1Holm mutation (11 available); any Ptprc mutation (189 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
spleen hyperplasia ( J:33466 )
• numbers of lymphoid cells in the spleen are greatly increased
abnormal T cell differentiation ( J:33466 )
• double positive to single positive transition inhibition is first noticeable in the first day after birth
increased double-negative T cell number ( J:33466 )
• proportion of double negative cells considerably increased
decreased double-positive T cell number ( J:33466 )
• double positive cells express elevated amounts of CD4 and CD8
• 2 fold decrease in double positive T cells
• double negative to double positive transition inhibition is first noticeable at E18
abnormal B cell number ( J:33466 )
• percentage of B cells in the spleen is normal
• absolute number of B cells in the spleen is 2X normal
• percentage of splenic B cells expressing high levels of IgM is increased although absolute numbers of low IgM cells is normal
decreased T cell number ( J:33466 )
• adult phenotype is established in the first week after birth
• 20% reduction in numbers of mature T cells in the spleen
decreased thymocyte number ( J:33466 )
• 50% reduction in total numbers of thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:33466 )
• CD4+ cells reduced to about 10% of normal
decreased CD8-positive, alpha-beta T cell number ( J:33466 )
• cell numbers are greatly reduced

immune system
spleen hyperplasia ( J:33466 )
• numbers of lymphoid cells in the spleen are greatly increased
abnormal T cell differentiation ( J:33466 )
• double positive to single positive transition inhibition is first noticeable in the first day after birth
increased double-negative T cell number ( J:33466 )
• proportion of double negative cells considerably increased
decreased double-positive T cell number ( J:33466 )
• double positive cells express elevated amounts of CD4 and CD8
• 2 fold decrease in double positive T cells
• double negative to double positive transition inhibition is first noticeable at E18
abnormal B cell number ( J:33466 )
• percentage of B cells in the spleen is normal
• absolute number of B cells in the spleen is 2X normal
• percentage of splenic B cells expressing high levels of IgM is increased although absolute numbers of low IgM cells is normal
decreased T cell number ( J:33466 )
• adult phenotype is established in the first week after birth
• 20% reduction in numbers of mature T cells in the spleen
decreased thymocyte number ( J:33466 )
• 50% reduction in total numbers of thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:33466 )
• CD4+ cells reduced to about 10% of normal
decreased CD8-positive, alpha-beta T cell number ( J:33466 )
• cell numbers are greatly reduced

endocrine/exocrine glands
decreased thymocyte number ( J:33466 )
• 50% reduction in total numbers of thymocytes

growth/size/body
spleen hyperplasia ( J:33466 )
• numbers of lymphoid cells in the spleen are greatly increased




Genotype
MGI:3032909
cx2
Allelic
Composition		 Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)2964Rmp/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprctm1Holm mutation (11 available); any Ptprc mutation (189 available)
Tg(Lck*F505)2964Rmp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes

immune system
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes

hematopoietic system
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes

endocrine/exocrine glands
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• extensive metastasis
• earliest morbidity at 5 weeks and median survival was to 9.5 weeks
• thymomas originate from immature thymocytes




Genotype
MGI:3032910
cx3
Allelic
Composition		 Ptprctm1Holm/Ptprctm1Holm
Tg(Lck*F505)3073Rmp/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprctm1Holm mutation (11 available); any Ptprc mutation (189 available)
Tg(Lck*F505)3073Rmp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• earliest morbidity at 10 weeks and median survival was to 12 weeks

immune system
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• earliest morbidity at 10 weeks and median survival was to 12 weeks

hematopoietic system
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• earliest morbidity at 10 weeks and median survival was to 12 weeks

endocrine/exocrine glands
thymus hyperplasia ( J:64671 )
• thymus glands with tumours also have 5X normal cell numbers
increased T cell derived lymphoma incidence ( J:64671 )
• aggressive thymic tumors in 100% of mice
• earliest morbidity at 10 weeks and median survival was to 12 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory