All Phenotypes Ccnd1<tm1Wbg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccnd1^tm1Wbg
targeted mutation 1, Robert A Weinberg
MGI:1857280

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg	involves: 129S2/SvPas	MGI:3576066
hm2	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg	involves: 129S2/SvPas * C57BL/6	MGI:3844431
hm3	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg	involves: 129S2/SvPas * CD-1	MGI:4431262
hm4	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg	involves: 129S2/SvPas * FVB/N	MGI:5300590
ht5	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc	involves: 129S2/SvPas	MGI:5468349
cn6	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5468350
cn7	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0 Tg(MMTV-Erbb2)NK1Mul/0	involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N	MGI:5468352
cx8	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Smarcb1^tm1Gvk/Smarcb1⁺	involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J	MGI:3603679
cx9	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTV-tTA)25755Kuw/0 Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0	involves: 129S2/SvPas * FVB/N	MGI:5300579
cx10	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTV-tTA)25755Kuw/0 Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0	involves: 129S2/SvPas * FVB/N	MGI:5300584
cx11	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0	involves: 129S2/SvPas * FVB/N	MGI:5300585
cx12	Ccnd1^tm1Wbg/Ccnd1⁺ Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0	involves: 129S2/SvPas * FVB/N	MGI:5300586
cx13	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0	involves: 129S2/SvPas * FVB/N	MGI:5300587
cx14	Ccnd1^tm1Wbg/Ccnd1⁺ Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0	involves: 129S2/SvPas * FVB/N	MGI:5300588
cx15	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTVneu)202Mul/0	involves: 129S2/SvPas * FVB/N	MGI:5300589
cx16	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Ccnd2^tm1Wbg/Ccnd2^tm1Wbg	Not Specified	MGI:3036177
cx17	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc	Not Specified	MGI:3036179

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:105045 )

• about 25% die during the first month of life

growth/size/body

postnatal growth retardation ( J:95994 , J:105045 )

• by the third week of life, mutants were approximately 1/2 of the size of wildtype (J:95994)

vision/eye

retina hypoplasia ( J:95994 , J:105045 )

• all cell layers (outer nuclear, inner nuclear, and ganglion cell layers) of the retina were hypoplastic (J:95994)

abnormal eye electrophysiology ( J:95994 , J:105045 )

• reduced amplitudes of the a- and b-waves in retinas in response to a pulse of light, with a-waves corresponding to 15% of those seen in wildtype (J:95994)

• retinas respond to light with electroretinographic potentials corresponding to about 10% of those seen in wild-type (J:105045)

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:95994 )

• underdeveloped mammary epithelial tree at the end of pregnancy

lactation failure ( J:95994 )

• unable to breast-feed pups due to abnormal mammary tissue development

reproductive system

abnormal mammary gland growth during pregnancy ( J:95994 )

• underdeveloped mammary epithelial tree at the end of pregnancy

behavior/neurological

limb grasping ( J:95994 )

• when lifted by tails, responded by rapidly retracting their limbs

integument

abnormal mammary gland growth during pregnancy ( J:95994 )

• underdeveloped mammary epithelial tree at the end of pregnancy

lactation failure ( J:95994 )

• unable to breast-feed pups due to abnormal mammary tissue development

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:55690 )

• mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy

vision/eye

retina hypoplasia ( J:55690 )

• hypoplastic and disorganized retina

abnormal eye electrophysiology ( J:55690 )

• have an essentially flat electroretinographic readout following light exposure

behavior/neurological

limb grasping ( J:55690 )

growth/size/body

postnatal growth retardation ( J:55690 )

• about 2 fold smaller than wild-type littermates at 3 weeks of age

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:55690 )

• mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:55690 )

• mammary epithelia transplanted into wild-type hosts fails to undergo lobuloalveolar development during pregnancy

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg
Genetic Background	involves: 129S2/SvPas * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:157019 )

• administration of recombinant EPHB2-Fc fusion protein does not reduce proliferation in either the colon or small intestine as it does in wild-type mice

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nursing ( J:178842 )

• mice exhibit normal nursing behavior and fail to rear offspring

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:178842 )

N	• mice exhibit normal mammary gland secretory alveoli proliferation and differentiation

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Ccnd1^tm5.1Pisc mutation (0 available); any Ccnd1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192032 )

• mice are phenotypically normal

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192032 )

• tamoxifen-treated mice exhibit no obvious abnormalities

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0 Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:192032 )

• tamoxifen-treatment halts cancer progression and lowers tumor burden with increased senescence of tumor cells compared to in control mice

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Smarcb1^tm1Gvk/Smarcb1⁺
Genetic Background	involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Smarcb1^tm1Gvk mutation (0 available); any Smarcb1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:101185 )

• absence of cyclin D1 blocks the rhabdoid tumor development normally found in Smarcb1 heterozygotes

vision/eye

abnormal eye development ( J:101185 )

• minor retinal developmental defects

growth/size/body

decreased body size ( J:101185 )

nervous system

abnormal nervous system development ( J:101185 )

• minor neurological developmental defects

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTV-tTA)25755Kuw/0 Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTV-tTA)25755Kuw mutation (0 available)
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:178842 )

N	• the mammary gland alveolar compartment develop normally

lactation failure ( J:178842 )

integument

lactation failure ( J:178842 )

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTV-tTA)25755Kuw/0 Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:178842 )

N	• the mammary gland alveolar compartment develop normally

lactation failure ( J:178842 )

integument

lactation failure ( J:178842 )

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 500 days

increased tumor latency ( J:178842 )

• development of palpable tumors in the mammary gland is delayed 3 to 4 months compared to in Ccnd1^tm1Wbg/Ccnd1⁺ Tg(MMTV-PyVT)634Mul Tg(TetO-Ccnd1T286A)11233Kuw mice

• however, latency is the same as in Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 500 days

integument

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 500 days

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1⁺ Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 300 days

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 300 days

integument

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 300 days

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 500 days

increased tumor latency ( J:178842 )

• development of palpable tumors in the mammary gland is delayed 3 to 4 months compared to in Ccnd1^tm1Wbg/Ccnd1⁺ Tg(MMTV-PyVT)634Mul Tg(TetO-Ccnd1T286A)10897Kuw mice

• however, latency is the same as in Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 500 days

integument

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 500 days

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1⁺ Tg(MMTVneu)202Mul/0 Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 300 days

integument

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 300 days

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:178842 )

• in all mice by 300 days

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Tg(MMTVneu)202Mul/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogenesis ( J:178842 )

• reduced

male infertility ( J:178842 )

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Ccnd2^tm1Wbg/Ccnd2^tm1Wbg
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Ccnd2^tm1Wbg mutation (0 available); any Ccnd2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:80994 )

behavior/neurological

impaired coordination ( J:80994 )

vision/eye

retina hypoplasia ( J:80994 )

nervous system

reduced cerebellar foliation ( J:80994 )

• decreased number of folia

• existing folia were stunted with interfolial clefts

ectopic Purkinje cell ( J:80994 )

• aberrantly located in the molecular and internal granule layers

absent Purkinje cell layer ( J:80994 )

• absence of a proper layer

abnormal cerebellar granule layer morphology ( J:80994 )

• decreased thickness

small cerebellum ( J:80994 )

• impaired development resulting in rudimentary formation

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:80994 )

• while mice were born near the expected frequency, most died within the first day demonstrating impaired suckling

• some mice survived the perinatal period

behavior/neurological

abnormal suckling behavior ( J:80994 )

growth/size/body

decreased body size ( J:80994 )

• mice that survived the perinatal period did not thrive and were much smaller than wild-type littermates in spite of a calorie-rich diet

respiratory system

aspiration ( J:80994 )

• suggestions of acute asphyxiation caused by meconium aspiration syndrome

vision/eye

retina hypoplasia ( J:80994 )

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