All Phenotypes Cd4<tm1Litt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd4^tm1Litt
targeted mutation 1, Dan R Littman
MGI:1857281

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd4^tm1Litt/Cd4^tm1Litt	involves: 129S2/SvPas	MGI:3800655
cn2	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3778Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655528
cn3	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655529
cn4	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3785Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655530
cx5	Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺	involves: 129 * C57BL/6	MGI:3765245
cx6	Cd4^tm1Litt/Cd4^tm1Litt Foxp3^sf Otc^spf/Y	involves: 129/Rl * 129S2/SvPas	MGI:3590077
cx7	Cd4^tm1Litt/Cd4^tm1Litt Tg(Cd4-CD4)2362Litt/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3800657

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Litt
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:50435 )

• CD4 T cells have decreased levels of proliferation in mixed lymphocyte cultures with cells expressing class II alloantigen

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• mice exhibit a near complete absence of CD4 expression in thymocytes, lamina propria lin-c-kit+CD127+ cells, and splenic TCRbeta-CD19-MHCII+CD11c+ cells compared to in wild-type mice

absent CD4-positive, alpha-beta T cells ( J:50435 )

• CD4 T cells are absent from both the thymus and the periphery

increased CD8-positive, alpha-beta T cell number ( J:50435 , J:158962 )

• 90% of peripheral alphabeta T cell are CD8-positive (J:50435)

• 93% of thymocytes are CD8-positive (J:50435)

abnormal CD4-positive, alpha-beta T cell physiology ( J:50435 )

• antibody production by B cells in response to the T cell dependent antigen TNP-KLH is 10-fold less than in controls

hematopoietic system

decreased T cell proliferation ( J:50435 )

• CD4 T cells have decreased levels of proliferation in mixed lymphocyte cultures with cells expressing class II alloantigen

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• mice exhibit a near complete absence of CD4 expression in thymocytes, lamina propria lin-c-kit+CD127+ cells, and splenic TCRbeta-CD19-MHCII+CD11c+ cells compared to in wild-type mice

absent CD4-positive, alpha-beta T cells ( J:50435 )

• CD4 T cells are absent from both the thymus and the periphery

increased CD8-positive, alpha-beta T cell number ( J:50435 , J:158962 )

• 90% of peripheral alphabeta T cell are CD8-positive (J:50435)

• 93% of thymocytes are CD8-positive (J:50435)

abnormal CD4-positive, alpha-beta T cell physiology ( J:50435 )

• antibody production by B cells in response to the T cell dependent antigen TNP-KLH is 10-fold less than in controls

cellular

decreased T cell proliferation ( J:50435 )

• CD4 T cells have decreased levels of proliferation in mixed lymphocyte cultures with cells expressing class II alloantigen

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3778Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (85 available)
Cd4^tm1Nik mutation (2 available); any Cd4 mutation (85 available)
Tg(Lck-cre)3778Nik mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal T-helper 2 physiology ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

abnormal interleukin-4 secretion ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal T-helper 2 physiology ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3785Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:73479 )

• increase in apoptosis of CD4 lineage T cells

increased T cell proliferation ( J:73479 )

• increase in proliferation of peripheral CD4 lineage cells

decreased CD4-positive, alpha-beta T cell number ( J:73479 )

• few peripheral CD4 lineage T cells

increased CD8-positive, alpha-beta T cell number ( J:73479 )

• increase in CD8+ T cells in lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4 lineage T cells exhibit an increase in proliferation and apoptosis

hematopoietic system

increased T cell apoptosis ( J:73479 )

• increase in apoptosis of CD4 lineage T cells

increased T cell proliferation ( J:73479 )

• increase in proliferation of peripheral CD4 lineage cells

decreased CD4-positive, alpha-beta T cell number ( J:73479 )

• few peripheral CD4 lineage T cells

increased CD8-positive, alpha-beta T cell number ( J:73479 )

• increase in CD8+ T cells in lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4 lineage T cells exhibit an increase in proliferation and apoptosis

cellular

increased T cell apoptosis ( J:73479 )

• increase in apoptosis of CD4 lineage T cells

increased T cell proliferation ( J:73479 )

• increase in proliferation of peripheral CD4 lineage cells

Allelic Composition	Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Doi mutation (0 available); any Cd4 mutation (85 available)
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (85 available)
Lag3^tm1Doi mutation (2 available); any Lag3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

hematopoietic system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Litt Foxp3^sf Otc^spf/Y
Genetic Background	involves: 129/Rl * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (85 available)
Foxp3^sf mutation (5 available); any Foxp3 mutation (58 available)
Otc^spf mutation (9 available); any Otc mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:20865 )

• signs of scurfy disease are delayed and are first seen at 4 weeks of age, with mutants dying at about 6 weeks of age

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:20865 )

• increase in the percentage of CD4-CD8+CD44+ and CD4-CD8+CD45RB^dull T cells compared to homozygous CD4 mice at 15 days of age

• decrease in the percentage of CD4-CD8+ T cells in aged mutants compared with aged homozygous CD4 mice

increased IgG level ( J:20865 )

• increased IgG in 35 day or older mutants, but not in 15 day old mutants

increased IgM level ( J:20865 )

• increased IgM in 35 day or older mutants, but not in 15 day old mutants

abnormal immune system organ morphology ( J:20865 )

• lymphoid organs in 15 day old mutants have typical scurfy lesions in T cell areas, but quiescent B cell areas

enlarged lymph nodes ( J:20865 )

• lymph nodes are normal size at day 15 but are enlarged by day 35

abnormal cytokine secretion ( J:20865 )

increased interleukin-4 secretion ( J:20865 )

• increased IL-4 production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice

increased interleukin-6 secretion ( J:20865 )

• increased IL-6 production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice

increased tumor necrosis factor secretion ( J:20865 )

• increased TNF-alpha production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:20865 )

• increase in the percentage of CD4-CD8+CD44+ and CD4-CD8+CD45RB^dull T cells compared to homozygous CD4 mice at 15 days of age

• decrease in the percentage of CD4-CD8+ T cells in aged mutants compared with aged homozygous CD4 mice

increased IgG level ( J:20865 )

• increased IgG in 35 day or older mutants, but not in 15 day old mutants

increased IgM level ( J:20865 )

• increased IgM in 35 day or older mutants, but not in 15 day old mutants

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Litt Tg(Cd4-CD4)2362Litt/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (85 available)
Tg(Cd4-CD4)2362Litt mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:50435 )

N	• the human CD4 transgene rescues the phenotype associated with Cd4^tm1Litt homozygotes

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