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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh1tm1Kem
targeted mutation 1, Rolf Kemler
MGI:1857282
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdh1tm1Kem/Cdh1tm1Kem involves: 129S2/SvPas MGI:5426972
hm2
 		Cdh1tm1Kem/Cdh1tm1Kem involves: 129S2/SvPas * C57BL/6 MGI:2448061
cn3
 		Cdh1tm1Kem/Cdh1tm2.1Kem involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3830622
cn4
 		Cdh1tm1Kem/Cdh1tm2Kem
Tg(MMTV-cre)1Kem/0 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3697584


Genotype
MGI:5426972
hm1
Allelic
Composition		 Cdh1tm1Kem/Cdh1tm1Kem
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm1Kem mutation (1 available); any Cdh1 mutation (173 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
absent blastocoele ( J:183847 )
• not rescued by blocking programmed cell death or activating insulin-like growth factor I receptor signaling




Genotype
MGI:2448061
hm2
Allelic
Composition		 Cdh1tm1Kem/Cdh1tm1Kem
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm1Kem mutation (1 available); any Cdh1 mutation (173 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
absent blastocoele ( J:19904 )
• failure to form blastocyst cavity
absent trophectoderm ( J:19904 )
• failure to form trophectodermal epithelium




Genotype
MGI:3830622
cn3
Allelic
Composition		 Cdh1tm1Kem/Cdh1tm2.1Kem
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm1Kem mutation (1 available); any Cdh1 mutation (173 available)
Cdh1tm2.1Kem mutation (0 available); any Cdh1 mutation (173 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell adhesion ( J:77170 )
• when treated with a cre-expressing plasmid, embryonic stem cells from E3.5 mice exhibit reduced cell to cell adhesion compared to wild-type embryonic cells




Genotype
MGI:3697584
cn4
Allelic
Composition		 Cdh1tm1Kem/Cdh1tm2Kem
Tg(MMTV-cre)1Kem/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm1Kem mutation (1 available); any Cdh1 mutation (173 available)
Cdh1tm2Kem mutation (1 available); any Cdh1 mutation (173 available)
Tg(MMTV-cre)1Kem mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal mammary gland growth during pregnancy ( J:77170 )
• on day 16 of pregnancy, mammary glands of pregnant mice show only occasional and small units of secretion compared to wild-type mice; this becomes more striking by day 18 and at parturition
• mammary gland is disorganized, with poorly developed, condensed alveoli at parturition

endocrine/exocrine glands
abnormal mammary gland growth during lactation ( J:77170 )
• at day 2 of lactation, majority of lobulo-alveolar structures have collapsed, leaving clusters of epithelial cords with small lumina and extensive tissue remodeling
abnormal mammary gland growth during pregnancy ( J:77170 )
• on day 16 of pregnancy, mammary glands of pregnant mice show only occasional and small units of secretion compared to wild-type mice; this becomes more striking by day 18 and at parturition
• mammary gland is disorganized, with poorly developed, condensed alveoli at parturition
abnormal milk composition ( J:77170 )
• expression of B-casein and whey acidic protein (WAP) re drastically reduced in mammary glands during lactation, indicating that gland is inefficient at producing milk proteins
lactation failure ( J:77170 )
• mutant mice cannot nurse their offspring due to mammary gland defects; 80% of offspring die within 24 hours and all die within 2-3 days of birth

integument
abnormal mammary gland growth during lactation ( J:77170 )
• at day 2 of lactation, majority of lobulo-alveolar structures have collapsed, leaving clusters of epithelial cords with small lumina and extensive tissue remodeling
abnormal mammary gland growth during pregnancy ( J:77170 )
• on day 16 of pregnancy, mammary glands of pregnant mice show only occasional and small units of secretion compared to wild-type mice; this becomes more striking by day 18 and at parturition
• mammary gland is disorganized, with poorly developed, condensed alveoli at parturition
abnormal milk composition ( J:77170 )
• expression of B-casein and whey acidic protein (WAP) re drastically reduced in mammary glands during lactation, indicating that gland is inefficient at producing milk proteins
lactation failure ( J:77170 )
• mutant mice cannot nurse their offspring due to mammary gland defects; 80% of offspring die within 24 hours and all die within 2-3 days of birth




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory