immune system
|
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis
|
|
• increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells
|
|
• zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours
• macrophage numbers also become elevated and remain elevated for 96 hours
|
nervous system
|
• completely abrogated in hippocampal slices
|
|
• significantly decreased
• synaptic fatigue is normal
|
behavior/neurological
|
• small but significant deficits in early training trials in water maze tests
• spatial learning impairments
|
|
• very slightly impaired motor coordination in a rotarod test
|
|
• less rearing in open field tests
|
neoplasm
|
• decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation
• greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls
|
|
• reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
chronic granulomatous disease | DOID:3265 |
OMIM:PS306400 |
J:146231 |