All Phenotypes Serpine1<tm1Mlg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpine1^tm1Mlg/Serpine1^tm1Mlg	B6.129S2-Serpine1^tm1Mlg/J	MGI:3690223
hm2	Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S2/SvPas	MGI:5763490
hm3	Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S2/SvPas * C57BL/6	MGI:3037601
hm4	Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S2/SvPas * C57BL/6 * C57BLKS/J	MGI:3803205
cx5	Apoe^tm1Unc/Apoe^tm1Unc Serpine1^tm1Mlg/Serpine1^tm1Mlg	B6.129-Serpine1^tm1Mlg Apoe^tm1Unc	MGI:3811066
cx6	Ldlr^tm1Her/Ldlr^tm1Her Serpine1^tm1Mlg/Serpine1^tm1Mlg	B6.129S-Serpine1^tm1Mlg Ldlr^tm1Her	MGI:3811068
cx7	Serpinb2^tm1Dgi/Serpinb2^tm1Dgi Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2	MGI:4837628
cx8	Lep^ob/Lep^ob Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S2/SvPas * C57BL/6	MGI:3037602
cx9	Lepr^db/Lepr^db Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S2/SvPas * C57BL/6 * C57BLKS/J	MGI:3803207
cx10	Serpinb2^tm2Dgi/Serpinb2^tm2Dgi Serpine1^tm1Mlg/Serpine1^tm1Mlg	involves: 129S2/SvPas * C57BL/6J * DBA/2J	MGI:4837627

Allelic Composition	Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	B6.129S2-Serpine1^tm1Mlg/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased angiogenesis ( J:108675 )

• aortic vessel explants show increased capillary sprouting in both collagen lattices and Matrigel

cardiac fibrosis ( J:101486 )

• older mutants develop cardiac fibrosis, however fibrosis is not seen in the liver, spleen, lungs or kidneys and do not develop small vessel disease

lung hemorrhage ( J:288556 )

• SARS-CoV MA15-infected mice show increased lung hemorrhage at 7 dpi

heart inflammation ( J:101486 )

• older mutants exhibit significantly more macrophages in the heart

respiratory system

lung hemorrhage ( J:288556 )

• SARS-CoV MA15-infected mice show increased lung hemorrhage at 7 dpi

immune system

heart inflammation ( J:101486 )

• older mutants exhibit significantly more macrophages in the heart

increased susceptibility to bacterial infection ( J:124327 )

• following infection with live Streptococcus pneumoniae, S. pneumoniae wild-type lysate, and S. pneumoniae pneumolysin (PLY), mice begin to die earlier and are all dead by 5 days post-infection

• following infection with S. pneumoniae, acute lung injury and alveolar hemorrhage is enhanced

• following infection with S. pneumoniae strain ATCC 6303 (a more virulent strain), mortality is increased (10% survival compared to 45% in wild-type mice)

increased susceptibility to Coronaviridae infection ( J:288556 )

• mice infected with a sublethal dose of mouse-adapted SARS-CoV MA15 continue to lose weight through day 7 postinfection, showing more weight loss than wild-type controls at 5-7 days post infection (dpi), decreased locomotion, hunched posture, and labored breathing

• SARS-CoV MA15-infected mice exhibit cuffing of inflammatory cells around the large airways and vasculature and mild interstitial membrane thickening and a few inflammatory cells in the alveolar spaces at 4 dpi, with moderate level of disease in the parenchyma by 7 dpi

• however, virus load of SARS-CoV MA15-infected mice is similar to wild-type controls

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:288556 )

• mice infected with a lethal dose of SARS-CoV MA15 succumb to infection sooner than wild-type controls

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:123733 )

• 3 weeks after BDL, urokinase plasminogen activator (uPA) and plasmin activity are not increased in mutants but tissue-type plasminogen activator (tPA) activity is significantly increased relative to wild-type

• 3 weeks after BDL, pro-MMP-9 and MMP-9 activities in liver homogenates from mutants are increased significantly compared to wild-type controls

liver/biliary system

liver/biliary system phenotype ( J:123733 )

N	• stellate cell activation, TGFbeta-1 and collagen synthesis are similar in mutants and controls before and after bile duct ligation

liver fibrosis ( J:123733 )

• 3 weeks after bile duct ligation (BDL), hepatic fibrosis is reduced 18-26% compared to wild-type; hepatic collagen content is similar to sham-operated wild-type

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:288556 )

• mice infected with a lethal dose of SARS-CoV MA15 succumb to infection sooner than wild-type controls

increased susceptibility to induced morbidity/mortality ( J:124327 )

• following infection with live Streptococcus pneumoniae, S. pneumoniae wild-type lysate, and S. pneumoniae pneumolysin (PLY), mice begin to die earlier and are all dead by 5 days post-infection

• following infection with S. pneumoniae strain ATCC 6303 (a more virulent strain), mortality is increased (10% survival compared to 45% in wild-type mice)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:288556

Allelic Composition	Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:229191 )

• in mice treated with LPS

immune system

decreased susceptibility to endotoxin shock ( J:229191 )

• LPS-treated mice exhibit increased survival compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:229191 )

• in mice treated with LPS

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body weight ( J:87982 )

• less weight gain on a high fat diet than normal

decreased body weight ( J:133227 )

• at 2 weeks, mutants remain below initial body weight after turpentine injection-induced weight loss but wild-type mice recover and begin to gain weight around 6-7 days after injection

weight loss ( J:133227 )

• turpentine injection induces significant weight loss in mutants and wild-type mice in initial 2 days; however, after 2 days, wild-type animals start to recover body weight whereas mutants do not

muscle

decreased skeletal muscle triglyceride level ( J:87982 )

• lower levels in skeletal muscle after 12 weeks on a high fat diet

immune system

immune system phenotype ( J:133227 )

N	• chemokine levels in injured tissue are similar between mutants and controls, peaking at 1-3 days

increased granulocyte number ( J:133227 )

• relative to controls following turpentine injection

abnormal interleukin level ( J:133227 )

• local Il6 levels in injured tissue at 8 hours post-injection are lower than in controls

decreased circulating interleukin-6 level ( J:133227 )

• plasma levels are markedly reduced at 8 hours after turpentine injection

abnormal acute inflammation ( J:133227 )

• in mutants after turpentine injection, serum amyloid P and C3 are significantly lower at 24 hours compared to wild-type and display a delayed peak at 3 days after injection

• C3 peak levels at day 3 are higher than in wild-type

• haptoglobin levels do not differ from wild-type at any time after turpentine injection

increased acute inflammation ( J:133227 )

• after turpentine injection to hind limb to induce tissue injury, 8 week-old mutants show significantly more local tissue injury compared to controls

• treatment resulted in local abscess formation and neutrophilic granulocyte infiltration encapsulated by macrophages and fibroblasts

glomerulonephritis ( J:85989 )

• higher incidence of fibrin positive crescents

• increased infiltration of injury with CD4+ T cells

• increased mortality

• increased thrombin production

respiratory system inflammation ( J:66093 )

• inflammation induced fibrosis in the lung occurs at a much slower rate

• survival is better

• fibrin content of lungs reduced generally

renal/urinary system

increased urine protein level ( J:85989 )

• an earlier enhancement of protein urea

glomerulonephritis ( J:85989 )

• higher incidence of fibrin positive crescents

• increased infiltration of injury with CD4+ T cells

• increased mortality

• increased thrombin production

glomerular crescent ( J:85989 )

• higher incidence of fibrin positive crescents

cardiovascular system

decreased angiogenesis ( J:65383 )

• neovascularization in general is reduced

abnormal blood circulation ( J:67531 )

• injury response in carotid arteries is reduced although cell proliferation in the adventitia is increased

• no fibrin present in the injured vessel walls

hematopoietic system

hematopoietic system phenotype ( J:39819 )

N	• bleeding time was normal

increased granulocyte number ( J:133227 )

• relative to controls following turpentine injection

respiratory system

respiratory system inflammation ( J:66093 )

• inflammation induced fibrosis in the lung occurs at a much slower rate

• survival is better

• fibrin content of lungs reduced generally

abnormal lung morphology ( J:31542 )

• no significant bleomycin-induced increase in lung collagen content is detected at 3 weeks posttreatment whereas treated wild-type mice show a significant increase in lung collagen; heterozygous mice are intermediate between null and wild-type in terms of collagen content

• lung fibrin deposition following bleomycin treatment is almost undetectable compared to treated wild-type mice

adipose tissue

decreased subcutaneous adipose tissue amount ( J:87982 )

• subcutaneous white fat pad mass was also reduced

abnormal epididymal fat pad morphology ( J:87982 )

• after 12 weeks on a high fat diet, epididymal fat pad was only 25% of wild-type

neoplasm

neoplasm ( J:33232 )

• no significant differences are observed compared to controls in terms of primary tumor size of footpad tumors induced by foot pad injection with tumor cells at 10, 17, or 21 days post-injection

• after injection of melanoma cells, number of primary pulmonary metastases post-injection, or tumor burdens initiated by injections of increasing doses of cells do not significantly differ from wild-type controls

• survival times after foot pad tumor removal are not significantly different among Serpine1-deficient, Serpine1-overexpressing transgenic, or wild-type mice

homeostasis/metabolism

increased body temperature ( J:87982 )

• increased on a high fat diet

abnormal energy expenditure ( J:87982 )

• increased after 12 weeks on a high fat diet

increased oxygen consumption ( J:87982 )

• after 12 weeks on a high fat diet, oxygen consumption is increased

decreased liver triglyceride level ( J:87982 )

• lower levels in liver after 12 weeks on a high fat diet

decreased skeletal muscle triglyceride level ( J:87982 )

• lower levels in skeletal muscle after 12 weeks on a high fat diet

abnormal interleukin level ( J:133227 )

• local Il6 levels in injured tissue at 8 hours post-injection are lower than in controls

decreased circulating interleukin-6 level ( J:133227 )

• plasma levels are markedly reduced at 8 hours after turpentine injection

increased urine protein level ( J:85989 )

• an earlier enhancement of protein urea

abnormal enzyme/coenzyme activity ( J:133227 )

• after 8 hours, myeloperoxidase (MPO) activity is higher in mutants in hind limb homogenates than in wild-type

enhanced wound healing ( J:72394 )

• dermal incisions healed more rapidly than normal

• thickened epidermal layer found within newly healed wounds

liver/biliary system

decreased liver triglyceride level ( J:87982 )

• lower levels in liver after 12 weeks on a high fat diet

integument

decreased subcutaneous adipose tissue amount ( J:87982 )

• subcutaneous white fat pad mass was also reduced

Allelic Composition	Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:127478 )

N	• mice do not develop significant albuminuria after 6 months of streptozotocin (STZ) -induced diabetes

increased blood urea nitrogen level ( J:127478 )

• STZ-treated mutants show elevated BUN levels compared to untreated mice, but levels are comparable to STZ-treated wild-type

hyperglycemia ( J:127478 )

• in streptozotocin-treated (STZ) mice (to induce diabetes), serum glucose is significantly increased compared to untreated mutant or wild-type controls

decreased circulating cholesterol level ( J:127478 )

• mean levels are significantly lower than in wild-type controls and STZ-treated mutants

renal/urinary system

abnormal kidney morphology ( J:127478 )

• total kidney collagen in STZ-treated mice increases only 8% compared to 40% in treated wild-type

abnormal renal glomerulus morphology ( J:127478 )

• glomerular extracellular matrix (ECM) area is greater than in wild-type controls; however, when expressed as fractional glomerular ECM area, little difference is observed between any genotype

• glomerular extracellular matrix (ECM) area is significantly higher compared to controls; after 6 months of STZ-induced diabetes, ECM area is decreased 15% compared to Serpine1 single deficient mice while in STZ-treated wild-type mice, ECM area is increased 64% relative to untreated wild-type mice

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	B6.129-Serpine1^tm1Mlg Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:61287 )

• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Apoe-deficient genotypes

• lesions are somewhat larger than those observed on the Ldlr-deficient background

• cellular composition of lesions is similar among Serpine-deficient or transgenic, Apoe-deficient genotypes, or Apoe-deficient only mice; at early time points, a greater foam cell content is observed, with more prominent cholesterol clefts and necrotic areas evident with increasing age

• fibrin deposition is not significantly different among Serpine-deficient or transgenic, Apoe-deficient genotypes, or Apoe-deficient only mice

homeostasis/metabolism

increased circulating cholesterol level ( J:61287 )

• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks)

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	B6.129S-Serpine1^tm1Mlg Ldlr^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (81 available)
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:61287 )

homeostasis/metabolism

increased circulating cholesterol level ( J:61287 )

• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks)

Allelic Composition	Serpinb2^tm1Dgi/Serpinb2^tm1Dgi Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2^tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:52283 )

N	• mice exhibit normal wound healing

Allelic Composition	Lep^ob/Lep^ob Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:70695 )

• serum insulin level was only moderately elevated from normal mice

• glucose administration caused only a moderate additional

impaired glucose tolerance ( J:70695 )

abnormal tumor necrosis factor level ( J:70695 )

• levels normal at birth but rise moderately with age

immune system

abnormal tumor necrosis factor level ( J:70695 )

• levels normal at birth but rise moderately with age

Allelic Composition	Lepr^db/Lepr^db Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^db mutation (17 available); any Lepr mutation (122 available)
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:127478 )

• 23% of females and 44% of males in the F3 generation died prematurely, of indeterminate cause

growth/size/body

obese ( J:127478 )

• female mice are obese relative to wild-type and Serpine1-deficient single mutant controls

decreased body size ( J:127478 )

• 63% of males in F3 generation are runts with body weight ranging from 20-40 grams compared to 60-100 grams for littermates not displaying runt phenotype

renal/urinary system

albuminuria ( J:127478 )

• present with slightly higher urinary albumin to creatinine ratios relative to Lepr single homozygotes

abnormal kidney morphology ( J:127478 )

• total kidney collagen is increased in females by 47% compared to female single Serpine1-deficient animals

abnormal renal glomerulus morphology ( J:127478 )

• glomerular extracellular matrix (ECM) areas are reduced 10% in females compared to female single Serpine1-deficient animals; however, when expressed as fractional glomerular ECM area, little difference is observed between any genotype

homeostasis/metabolism

increased blood urea nitrogen level ( J:127478 )

• significantly higher BUN levels compared to Serpine1-deficient single mutants

hyperglycemia ( J:127478 )

• hyperglycemia is less severe than observed in Serpine1-sufficient, Lepr-deficient controls at 10, 14, and 34 weeks of age

albuminuria ( J:127478 )

• present with slightly higher urinary albumin to creatinine ratios relative to Lepr single homozygotes

abnormal enzyme/coenzyme activity ( J:127478 )

• total urokinase plasminogen activator (uPA) activity is significantly higher than wild-type compared to Serpine1-sufficient diabetic controls

Allelic Composition	Serpinb2^tm2Dgi/Serpinb2^tm2Dgi Serpine1^tm1Mlg/Serpine1^tm1Mlg
Genetic Background	involves: 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2^tm2Dgi mutation (0 available); any Serpinb2 mutation (32 available)
Serpine1^tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:52283 )

N	• mice exhibit normal wound healing

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