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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plaurtm1Jld
targeted mutation 1, Jay L Degen
MGI:1857290
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plaurtm1Jld/Plaurtm1Jld B6.129P2-Plaurtm1Jld MGI:4836582
hm2
 		Plaurtm1Jld/Plaurtm1Jld involves: 129P2/OlaHsd * Black Swiss MGI:3521784
hm3
 		Plaurtm1Jld/Plaurtm1Jld involves: 129P2/OlaHsd * C57BL/6 MGI:3521786
hm4
 		Plaurtm1Jld/Plaurtm1Jld involves: 129P2/OlaHsd * C57BL/6J MGI:3690640
cx5
 		Plaurtm1Jld/Plaurtm1Jld
Tg(MSR1-Plau)1Ddi/0 		B6.Cg-Plaurtm1Jld Tg(MSR1-Plau)1Ddi MGI:3690230


Genotype
MGI:4836582
hm1
Allelic
Composition		 Plaurtm1Jld/Plaurtm1Jld
Genetic
Background		 B6.129P2-Plaurtm1Jld
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation (2 available); any Plaur mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
chronic inflammation ( J:164542 )
• chronic inflammation is secondary to fibrin deposition
increased inflammatory response ( J:164542 )
• in the liver
• in the trachea of 3 in 7 mice
• however, leukocyte accumulation in standard models of inflammation is normal
liver inflammation ( J:164542 )
• the number of inflammatory foci is increased compared to in wild-type mice
trachea inflammation ( J:164542 )
• 3 of 7 mice exhibit mild to moderate inflammation of the trachea unlike wild-type mice

respiratory system
trachea inflammation ( J:164542 )
• 3 of 7 mice exhibit mild to moderate inflammation of the trachea unlike wild-type mice

liver/biliary system
liver inflammation ( J:164542 )
• the number of inflammatory foci is increased compared to in wild-type mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:164542 )
N
• skin wound healing is normal




Genotype
MGI:3521784
hm2
Allelic
Composition		 Plaurtm1Jld/Plaurtm1Jld
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation (2 available); any Plaur mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:26874 )
N
• homozygotes exhibit a redistribution of urokinase plasminogen activator (uPA) in some tissues but show no changes in the accumulation or proteolytic activation of uPA in the urogenital tract
• as in wild-type mice, most of the uPA in the urine of mutant mice is in the two-chain form

immune system
abnormal macrophage physiology ( J:26874 )
• activated peritoneal macrophages from mutant mice fail to promote cell-surface plasminogen activation in vitro; however, homozygotes are viable, fertile and survive to adulthood with no apparent anatomical defects
• also, homozygotes that are unchallenged by disease, infection or injury show no pathological lesions or hepatic fibrin deposits up to 6-8 months of age

hematopoietic system
abnormal macrophage physiology ( J:26874 )
• activated peritoneal macrophages from mutant mice fail to promote cell-surface plasminogen activation in vitro; however, homozygotes are viable, fertile and survive to adulthood with no apparent anatomical defects
• also, homozygotes that are unchallenged by disease, infection or injury show no pathological lesions or hepatic fibrin deposits up to 6-8 months of age




Genotype
MGI:3521786
hm3
Allelic
Composition		 Plaurtm1Jld/Plaurtm1Jld
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation (2 available); any Plaur mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:63134 )
N
• 14 days after bleomycin treatment, wild-type and mutant mice display a similar increase in lung collagen (hydroxyproline) content
• 14 days after bleomycin treatment, wild-type and mutant mice show similar focal areas of pulmonary fibrosis surrounded by normal alveoli; no intra-alveolar hemorrhage or early deaths are observed




Genotype
MGI:3690640
hm4
Allelic
Composition		 Plaurtm1Jld/Plaurtm1Jld
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation (2 available); any Plaur mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:108675 )
• aortic vessel explants show a reduced rate of sprouting (2/3 of controls) in collagen lattices




Genotype
MGI:3690230
cx5
Allelic
Composition		 Plaurtm1Jld/Plaurtm1Jld
Tg(MSR1-Plau)1Ddi/0
Genetic
Background		 B6.Cg-Plaurtm1Jld Tg(MSR1-Plau)1Ddi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation (2 available); any Plaur mutation (18 available)
Tg(MSR1-Plau)1Ddi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac fibrosis ( J:113474 )
• exhibit more fibrosis at 15 weeks of age than single Plaur homozygotes although show a similar degree of fibrosis as seen in single Tg(MSR1-Plau)1Ddi mutants
heart inflammation ( J:113474 )
• exhibit significantly more cardiac macrophages at 15 weeks of age than single Plaur homozygotes, however show a similar accumulation as seen in single Tg(MSR1-Plau)1Ddi mutants

immune system
heart inflammation ( J:113474 )
• exhibit significantly more cardiac macrophages at 15 weeks of age than single Plaur homozygotes, however show a similar accumulation as seen in single Tg(MSR1-Plau)1Ddi mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory