All Phenotypes Hprt1<b-m1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^b-m1
hypoxanthine guanine phosphoribosyl transferase B, mutation 1
MGI:1857297

Summary

2 genotypes

Allelic Composition	Hprt1^b-m1/Y
Genetic Background	involves: 129 * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^b-m1 mutation (0 available); any Hprt1 mutation (1279 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:115724 )

N	• mice exhibit overall similar behavior as observed in wild-type mice in open field, bridge, passive avoidance and apomorphine-induced activity tests

• male mice make less slips when climbing than escape platform in a swim test compared to Hprt1^b-m2 male mice

decreased vertical activity ( J:115724 )

• male mice spend more time in the center of an open field than Hprt1^b-m2 male mice

homeostasis/metabolism

decreased dopamine level ( J:115724 )

• striatal concentrations of dopamine are lower than in wild-type mice

Allelic Composition	Hprt1^b-m1/Y
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^b-m1 mutation (0 available); any Hprt1 mutation (1279 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:3354 , J:15485 )

N	• mice exhibit normal behavior (J:3354) (J:15485)

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