Phenotypes associated with this allele

• Allele Symbol: Hprt1^b-m2
• Allele Name: hypoxanthine guanine phosphoribosyl transferase B, mutation 2
• Allele ID: MGI:1857298
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Hprt1^b-m2/Y	involves: 129 * 129S/SvEv	MGI:3810361
ot2	Hprt1^b-m2/Y	involves: 129S/SvEv	MGI:3810339

Genotype
MGI:3810361

ot1

• Allelic Composition: Hprt1^b-m2/Y
• Genetic Background: involves: 129 * 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:115724 )

♂N • mice exhibit overall similar behavior as observed in wild-type mice in open field, bridge, passive avoidance and apomorphine-induced activity tests

abnormal motor coordination/balance ( J:115724 )

♂ • male mice make more slips when climbing than escape platform in a swim test compared to Hprt1^b-m1 male mice

abnormal locomotor activation ( J:115724 )

♂ • male mice spend less time in the center of an open field than Hprt1^b-m1 male mice

homeostasis/metabolism

decreased dopamine level ( J:115724 )

♂ • striatal concentrations of dopamine are lower than in wild-type mice

Genotype
MGI:3810339

ot2

• Allelic Composition: Hprt1^b-m2/Y
• Genetic Background: involves: 129S/SvEv

behavior/neurological

behavior/neurological phenotype ( J:3354 , J:15485 )

♂N • mice exhibit normal behavior (J:3354)

♂N (J:15485)