homeostasis/metabolism
Allele Symbol Allele Name Allele ID |
Apobtm1Sgy targeted mutation 1, Stephen G Young MGI:1857303 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit more atherosclerotic lesions in aortas than single Apoetm1Unc homozygotes
• mice exhibit atherosclerotic lesions in the aortic root to a similar extent as in single Apoetm1Unc homozygotes
• most lesions are located in the aortic arch, although some lesions extend into the thoracic and abdominal aortas
• extent of atherosclerosis correlates with plasma cholesterol levels
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• mice are heavier than single Apoetm1Unc homozygotes at 200 days of age
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• total cholesterol levels are higher than in single Apoetm1Unc homozygotes at 7 weeks, 3 and 6 months, and 200 days
• plasma cholesterol levels increase significantly with time
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• very high levels of VLDL cholesterol
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• triglyceride levels are higher than in single Apoetm1Unc homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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