Phenotypes associated with this allele

• Allele Symbol: Apob^tm1Sgy
• Allele Name: targeted mutation 1, Stephen G Young
• Allele ID: MGI:1857303
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apob^tm1Sgy/Apob^tm1Sgy	involves: 129/Sv * C57BL/6	MGI:2661994
cx2	Apob^tm1Sgy/Apob^tm1Sgy Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5882610

Genotype
MGI:2661994

hm1

• Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating LDL cholesterol level ( J:33830 )

decreased circulating triglyceride level ( J:33830 )

Genotype
MGI:5882610

cx2

• Allelic Composition: Apob^tm1Sgy/Apob^tm1Sgy; Apoe^tm1Unc/Apoe^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

cardiovascular system

increased susceptibility to atherosclerosis ( J:41510 )

• mice exhibit more atherosclerotic lesions in aortas than single Apoe^tm1Unc homozygotes

• mice exhibit atherosclerotic lesions in the aortic root to a similar extent as in single Apoe^tm1Unc homozygotes

• most lesions are located in the aortic arch, although some lesions extend into the thoracic and abdominal aortas

• extent of atherosclerosis correlates with plasma cholesterol levels

growth/size/body

increased body weight ( J:41510 )

• mice are heavier than single Apoe^tm1Unc homozygotes at 200 days of age

homeostasis/metabolism

increased circulating cholesterol level ( J:41510 )

• total cholesterol levels are higher than in single Apoe^tm1Unc homozygotes at 7 weeks, 3 and 6 months, and 200 days

• plasma cholesterol levels increase significantly with time

increased circulating VLDL cholesterol level ( J:41510 )

• very high levels of VLDL cholesterol

increased circulating triglyceride level ( J:41510 )

• triglyceride levels are higher than in single Apoe^tm1Unc homozygotes