homeostasis/metabolism
|
• serum phosphate is significantly reduced relative to wild-type but similarity in serum phosphate levels between heterozygotes, homozygotes and hemizygotes indicates that there is not a gene dose effect
|
limbs/digits/tail
|
• the overall length of the proximal caudal vertebrae is shorter, the growth plate is thicker than in wild-type controls, and there is accumulation of osteoid
|
skeleton
|
• the overall length of the proximal caudal vertebrae is shorter, the growth plate is thicker than in wild-type controls, and there is accumulation of osteoid
|
osteomalacia
(
J:87808
)
|
• there is a significant increase in cancellous osteoid volume per bone volume, and cancellous, endocortical, and periosteal osteoid thickness
|
cellular
|
• heterozygous offspring from homozygous females have shorter caudal vertebrae and increased osteoid within cancellous bone than do heterozygotes derived from hemizygous males
|