All Phenotypes Ednrb<s-36Pub> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednrb^s-36Pub/Ednrb^s-36Pub	B6.Cg-Ednrb^s-36Pub	MGI:3759580
hm2	Ednrb^s-36Pub/Ednrb^s-36Pub	involves: 101/Rl * C3H/Rl	MGI:3850247
ht3	Ednrb^s-36Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850248
ht4	Ednrb^s/Ednrb^s-36Pub	involves: 101/Rl * C3H/Rl	MGI:3850249
cx5	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)2Tpo/0	B6.Cg-Ednrb^s-36Pub Tg(Spry2)2Tpo	MGI:3759582
cx6	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)69Tpo/0	B6.Cg-Ednrb^s-36Pub Tg(Spry2)69Tpo	MGI:3759584
cx7	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J	MGI:3759579

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal secondary palate development ( J:125229 )

• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth

cleft upper lip ( J:125229 )

• incidence is 27%

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

abnormal soft palate morphology ( J:125229 )

• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth

cleft secondary palate ( J:125229 )

• homozygotes show high incidence (83%) of cleft secondary palate

failure of palatal shelf elevation ( J:125229 )

• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate

• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

skeleton

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal bone ossification ( J:125229 )

• extent of ossification in palate at E15.5 is significantly reduced compared to wild-type

digestive/alimentary system

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal secondary palate development ( J:125229 )

• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

abnormal soft palate morphology ( J:125229 )

• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth

cleft secondary palate ( J:125229 )

• homozygotes show high incidence (83%) of cleft secondary palate

failure of palatal shelf elevation ( J:125229 )

• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate

• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

cellular

increased mitotic index ( J:125229 )

• at E14.5, mitotic index in palates is increased relative to wild-type; indices are also elevated regionally compared to wild-type at E13.5 and E15.5

increased cell proliferation ( J:125229 )

• proliferation is elevated in epithelium and mesenchyme, most significantly in the mid to posterior palate

growth/size/body

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal secondary palate development ( J:125229 )

• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth

cleft upper lip ( J:125229 )

• incidence is 27%

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

abnormal soft palate morphology ( J:125229 )

• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth

cleft secondary palate ( J:125229 )

• homozygotes show high incidence (83%) of cleft secondary palate

failure of palatal shelf elevation ( J:125229 )

• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate

• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

Allelic Composition	Ednrb^s-36Pub/Ednrb^s-36Pub
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:16291 , J:100221 )

nervous system

abnormal nervous system morphology ( J:100221 )

skeleton

abnormal skeleton morphology ( J:100221 )

abnormal cartilage morphology ( J:100221 )

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s/Ednrb^s-36Pub
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s mutation (19 available); any Ednrb mutation (104 available)
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

pigmentation

white spotting ( J:100221 )

integument

white spotting ( J:100221 )

Allelic Composition	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)2Tpo/0
Genetic Background	B6.Cg-Ednrb^s-36Pub Tg(Spry2)2Tpo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)
Tg(Spry2)2Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:125229 )

N	• transgenic mice show complete rescue of cleft lip phenotype

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

skeleton

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

growth/size/body

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

Allelic Composition	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)69Tpo/0
Genetic Background	B6.Cg-Ednrb^s-36Pub Tg(Spry2)69Tpo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)
Tg(Spry2)69Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:125229 )

N	• transgenic mice show complete rescue of cleft lip phenotype

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

skeleton

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

growth/size/body

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺
Genetic Background	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

digestive/alimentary system

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

growth/size/body

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24