All Phenotypes Ednrb<s-36Pub> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednrb^s-36Pub/Ednrb^s-36Pub	B6.Cg-Ednrb^s-36Pub	MGI:3759580
hm2	Ednrb^s-36Pub/Ednrb^s-36Pub	involves: 101/Rl * C3H/Rl	MGI:3850247
ht3	Ednrb^s-36Pub/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850248
ht4	Ednrb^s/Ednrb^s-36Pub	involves: 101/Rl * C3H/Rl	MGI:3850249
cx5	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)2Tpo/0	B6.Cg-Ednrb^s-36Pub Tg(Spry2)2Tpo	MGI:3759582
cx6	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)69Tpo/0	B6.Cg-Ednrb^s-36Pub Tg(Spry2)69Tpo	MGI:3759584
cx7	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J	MGI:3759579

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal secondary palate development ( J:125229 )

• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth

cleft upper lip ( J:125229 )

• incidence is 27%

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

abnormal soft palate morphology ( J:125229 )

• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth

cleft secondary palate ( J:125229 )

• homozygotes show high incidence (83%) of cleft secondary palate

failure of palatal shelf elevation ( J:125229 )

• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate

• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

skeleton

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal bone ossification ( J:125229 )

• extent of ossification in palate at E15.5 is significantly reduced compared to wild-type

digestive/alimentary system

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal secondary palate development ( J:125229 )

• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

abnormal soft palate morphology ( J:125229 )

• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth

cleft secondary palate ( J:125229 )

• homozygotes show high incidence (83%) of cleft secondary palate

failure of palatal shelf elevation ( J:125229 )

• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate

• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

cellular

increased mitotic index ( J:125229 )

• at E14.5, mitotic index in palates is increased relative to wild-type; indices are also elevated regionally compared to wild-type at E13.5 and E15.5

increased cell proliferation ( J:125229 )

• proliferation is elevated in epithelium and mesenchyme, most significantly in the mid to posterior palate

growth/size/body

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology

absent palatine bone horizontal plate ( J:125229 )

• at E18.5, palatal processes of palatine bones are absent

abnormal secondary palate development ( J:125229 )

• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth

cleft upper lip ( J:125229 )

• incidence is 27%

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

abnormal soft palate morphology ( J:125229 )

• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth

cleft secondary palate ( J:125229 )

• homozygotes show high incidence (83%) of cleft secondary palate

failure of palatal shelf elevation ( J:125229 )

• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate

• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

Allelic Composition	Ednrb^s-36Pub/Ednrb^s-36Pub
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:16291 , J:100221 )

nervous system

abnormal nervous system morphology ( J:100221 )

skeleton

abnormal skeleton morphology ( J:100221 )

abnormal cartilage morphology ( J:100221 )

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s/Ednrb^s-36Pub
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s mutation (19 available); any Ednrb mutation (104 available)
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

pigmentation

white spotting ( J:100221 )

integument

white spotting ( J:100221 )

Allelic Composition	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)2Tpo/0
Genetic Background	B6.Cg-Ednrb^s-36Pub Tg(Spry2)2Tpo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)
Tg(Spry2)2Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:125229 )

N	• transgenic mice show complete rescue of cleft lip phenotype

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

skeleton

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

growth/size/body

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

Allelic Composition	Ednrb^s-36Pub/Ednrb^s-36Pub Tg(Spry2)69Tpo/0
Genetic Background	B6.Cg-Ednrb^s-36Pub Tg(Spry2)69Tpo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)
Tg(Spry2)69Tpo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:125229 )

N	• transgenic mice show complete rescue of cleft lip phenotype

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

skeleton

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

growth/size/body

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺
Genetic Background	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (104 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

digestive/alimentary system

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

growth/size/body

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

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