All Phenotypes Bcl2l2<Gt(ROSA)41Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor}	involves: 129S5/SvEvBrd	MGI:2176736
hm2	Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor}	involves: 129S5/SvEvBrd * C57BL/6J	MGI:2665821
cx3	Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor} Grid2^ho-4J/Grid2^ho-4J	involves: 129S5/SvEvBrd * DBA/2J	MGI:3834108

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased seminal vesicle weight ( J:46386 )

• progressive weight reduction after 5 months of age, resulting in weights 10% those of normal at 14 months of age

abnormal seminiferous tubule morphology ( J:46386 )

• tubules are devoid of germ cells by 6 months of age

• by 8 months of age most sertoli cells had sloughed off and there was reduction in the number of leydig cells

small testis ( J:46386 )

nervous system

abnormal Purkinje cell mitochondrial morphology ( J:137190 )

• mitochondria lengths in Purkinje cells are 1.4-1.5 um, compared to lengths of 0.8-1.0 um in wild-type animals

• often, points where mitochondria become constricted are observed in mutants but not in wild-type mitochondria, suggestive of impaired fission

abnormal Purkinje cell dendrite morphology ( J:137190 )

• large numbers of naked dendritic spines are present

abnormal CNS synapse formation ( J:137190 )

• mismatched connections between pre- and postsynaptic active zones of Purkinje cell/parallel fiber synapses are frequently seen

• other synaptic defects such as shortened active zones and thickened postsynaptic densities

behavior/neurological

abnormal motor learning ( J:137190 )

• mice fail to improve performance in rotating rod trials in contrast to wild-type animals

reproductive system

decreased male germ cell number ( J:46386 )

• degenerating spermatocytes are first observed at 19 days of age

• 10-fold decrease in the number of spermatids by 24 days of age

• all stages of developing germ cells were observed at 2.5 months of age, though most were lost by 5 months of age

decreased seminal vesicle weight ( J:46386 )

• progressive weight reduction after 5 months of age, resulting in weights 10% those of normal at 14 months of age

abnormal seminiferous tubule morphology ( J:46386 )

• tubules are devoid of germ cells by 6 months of age

• by 8 months of age most sertoli cells had sloughed off and there was reduction in the number of leydig cells

small testis ( J:46386 )

male infertility ( J:46386 )

cellular

decreased male germ cell number ( J:46386 )

• degenerating spermatocytes are first observed at 19 days of age

• 10-fold decrease in the number of spermatids by 24 days of age

• all stages of developing germ cells were observed at 2.5 months of age, though most were lost by 5 months of age

abnormal Purkinje cell mitochondrial morphology ( J:137190 )

• mitochondria lengths in Purkinje cells are 1.4-1.5 um, compared to lengths of 0.8-1.0 um in wild-type animals

• often, points where mitochondria become constricted are observed in mutants but not in wild-type mitochondria, suggestive of impaired fission

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:46386 )

• increased levels observed between 2.5 and 15 months of age

Allelic Composition	Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor}
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l2^{Gt(ROSA)41Sor} mutation (2 available); any Bcl2l2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased germ cell number ( J:70212 )

endocrine/exocrine glands

decreased seminal vesicle weight ( J:70212 )

• progressive weight reduction after 7.5 months of age, resulting in weights 10% those of normal at 12 months of age

abnormal Sertoli cell barrier morphology ( J:70212 )

• an intact blood-testis barrier was observed at 90 days of age, but not at 5.5 months of age

decreased Sertoli cell number ( J:70212 )

• progressive reduction in the number of cells beginning at 23 days of age

• 60% reduction relative to wild-type at 90 days of age and reaching 0% in some cases by 12 months of age

small seminiferous tubules ( J:70212 )

• reduction of luminal volume

absent Leydig cells ( J:70212 )

• following hyperplasia, a gradual loss of cells was observed from 8 to 12 months, at which point few to no Leydig cells were observed

increased Leydig cell number ( J:70212 )

• increased number of leydig cells relative to wild-type between 3 and 8 months of age

decreased testis weight ( J:70212 )

• progressive weight reduction first evident at 34 days of age

• testicular weight was 12 to 20% that of wild-type at 9 months of age

reproductive system

decreased germ cell number ( J:70212 )

decreased seminal vesicle weight ( J:70212 )

• progressive weight reduction after 7.5 months of age, resulting in weights 10% those of normal at 12 months of age

abnormal Sertoli cell barrier morphology ( J:70212 )

• an intact blood-testis barrier was observed at 90 days of age, but not at 5.5 months of age

decreased Sertoli cell number ( J:70212 )

• progressive reduction in the number of cells beginning at 23 days of age

• 60% reduction relative to wild-type at 90 days of age and reaching 0% in some cases by 12 months of age

small seminiferous tubules ( J:70212 )

• reduction of luminal volume

absent Leydig cells ( J:70212 )

• following hyperplasia, a gradual loss of cells was observed from 8 to 12 months, at which point few to no Leydig cells were observed

increased Leydig cell number ( J:70212 )

• increased number of leydig cells relative to wild-type between 3 and 8 months of age

decreased testis weight ( J:70212 )

• progressive weight reduction first evident at 34 days of age

• testicular weight was 12 to 20% that of wild-type at 9 months of age

Allelic Composition	Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor} Grid2^ho-4J/Grid2^ho-4J
Genetic Background	involves: 129S5/SvEvBrd * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l2^{Gt(ROSA)41Sor} mutation (2 available); any Bcl2l2 mutation (19 available)
Grid2^ho-4J mutation (1 available); any Grid2 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:137190 )

• smaller than wild-type or single-mutant animals

behavior/neurological

ataxia ( J:137190 )

• when manually induced to move, animals respond with a very ataxic gait

• due to severity of ataxia, mice could not be tested on rotating rod apparatus

abnormal gait ( J:137190 )

bradykinesia ( J:137190 )

• mice exhibit very little movement relative to wild-type or single mutants

nervous system

abnormal cerebellum morphology ( J:137190 )

• cerebellum is smaller than wild-type or single mutant mice

abnormal cerebellar Purkinje cell layer ( J:137190 )

• layer is overcrowded in the smaller cerebellum compared to controls, however Purkinje cell numbers are not different

abnormal Purkinje cell morphology ( J:137190 )

• approximately 45% of cells analyzed have 2 dendritic branches instead of the single primary branch seen in wild-type

abnormal Purkinje cell mitochondrial morphology ( J:137190 )

• mitochondria lengths in Purkinje cell dendrites are 1.8-1.9 um, significantly longer than those of either single mutant or wild-type

• frequently, mitochondria contain sites of thinning and constriction; in some instances, cristae in mitochondria appear slightly dilated

• extremely long mitochondria that extend for much of the visible length of the dendrites are frequently seen

abnormal Purkinje cell dendrite morphology ( J:137190 )

• large numbers of naked dendritic spines are present, similar in number to Bcl2l2^{Gt(ROSA)41Sor} mice

• dendritic arbors are reduced in number and complexity relative to controls

• numbers of branches in arbors of each level of complexity are decreased

• spacing of dendritic spines is abnormal, with spines crowded onto dendrites in contrast to regular spacing in wild-type and single mutant cells

• spines are shorter and often are branched or lack a characteristic spine head or neck

abnormal CNS synapse formation ( J:137190 )

• mismatched connections between pre- and postsynaptic active zones of Purkinje cell/parallel fiber synapses are frequently seen

• other synaptic defects such as shortened active zones and thickened postsynaptic densities

decreased CNS synapse formation ( J:137190 )

cellular

abnormal Purkinje cell mitochondrial morphology ( J:137190 )

• mitochondria lengths in Purkinje cell dendrites are 1.8-1.9 um, significantly longer than those of either single mutant or wild-type

• frequently, mitochondria contain sites of thinning and constriction; in some instances, cristae in mitochondria appear slightly dilated

• extremely long mitochondria that extend for much of the visible length of the dendrites are frequently seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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