All Phenotypes Fosb<tm1Meg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fosb^tm1Meg
targeted mutation 1, Michael E Greenburg
MGI:1857395

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fosb^tm1Meg/Fosb^tm1Meg	either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129S4/SvJae * 129X1/SvJ * BALB/c)	MGI:3653349
hm2	Fosb^tm1Meg/Fosb^tm1Meg	involves: 129S4/SvJae * 129X1/SvJ	MGI:3653339
hm3	Fosb^tm1Meg/Fosb^tm1Meg	involves: 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3653352
ht4	Fosb^tm1Meg/Fosb⁺	involves: 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3653353

Allelic Composition	Fosb^tm1Meg/Fosb^tm1Meg
Genetic Background	either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129S4/SvJae * 129X1/SvJ * BALB/c)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm1Meg mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal parental behavior ( J:34461 )

• young homozygous males display defective nurturing behavior illustrated by impaired pup retrieval compared to wild-type males

abnormal maternal nurturing ( J:34461 )

• majority of pups die within 1 to 2 days of birth regardless of their genotype

• homozygous pups will survive if fostered by wild-type or heterozygous females

• Background Sensitivity: if homozygous females are mated to homozygous, heterozygous or wild-type males on a 129 background, 0-1 pups on average survive to weaning regardless of pup genotype; if homozygous males are mated to heterozygous or wild-type females, 3-5 pups survive to weaning regardless of pup genotype

• Background Sensitivity: if homozygous females are mated to homozygous, heterozygous or wild-type males on 129/B6 background, only 1-2 pups survive to weaning regardless of pup genotype; if homozygous males are mated to heterozygous or wild-type females, 7-9 pups survive to weaning regardless of genotype

abnormal nursing ( J:34461 )

• homozygous females do not nurse their pups

abnormal pup retrieval ( J:34461 )

• if 3 pups are removed from the cage then replaced shortly after, homozygous females take 50 times longer to retrieve the first pup compared to wild-type or heterozygotes and only 50% retrieve even one pup

growth/size/body

decreased body size ( J:34461 )

• homozygotes are about ~10% smaller than wild-type

Allelic Composition	Fosb^tm1Meg/Fosb^tm1Meg
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm1Meg mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:110995 )

• 2-3 month old mutant mice show a significant delay in development of tolerance to motor seizures compared to wild-type mice; repeated ECS treatment does eventually result in a significant reduction in seizure duration, to wild-type levels by day 6 of treatment

nervous system

abnormal seizure response to electrical stimulation ( J:110995 )

reduced NMDA-mediated synaptic currents ( J:110995 )

• in layer II/III pyramidal cells, repeated ECS treatments does not alter 25 um NMDA-induced inward current but currents in wild-type cells are significantly enhanced in brain slices from 2-3 month old mutants

Allelic Composition	Fosb^tm1Meg/Fosb^tm1Meg
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm1Meg mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal frequency of paradoxical sleep ( J:64368 )

• mutants display a significant decrease (41.5%) in REM sleep during lights-on periods; there is a significant decrease (31.5%) in REM sleep during the lights-out period compared to wild-type

Allelic Composition	Fosb^tm1Meg/Fosb⁺
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm1Meg mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal frequency of paradoxical sleep ( J:64368 )

• mice show fewer numbers of REM sleep bouts than wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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