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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp2b2dfw-2J
deaf waddler 2 Jackson
MGI:1857396
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp2b2dfw-2J/Atp2b2dfw-2J CBA.Cg-Atp2b2dfw-2J MGI:5696186
hm2
 		Atp2b2dfw-2J/Atp2b2dfw-2J CByJ.A-Atp2b2dfw-2J/J MGI:3580890
ht3
 		Atp2b2dfw-2J/Atp2b2+ CBA.Cg-Atp2b2dfw-2J MGI:5696187
ht4
 		Atp2b2dfw-2J/Atp2b2+ CByJ.A-Atp2b2dfw-2J/J MGI:3580891
ht5
 		Atp2b2dfw-2J/Atp2b2+ involves: CAST/Ei * BALB/cByJ MGI:4436907
cx6
 		Atp2b2dfw-2J/Atp2b2+
Cdh23ahl/Cdh23ahl 		involves: BALB/cByJ * MOLF MGI:3695310
cx7
 		Atp2b2dfw-2J/Atp2b2+
Cdh23ahl/Cdh23ahl 		involves: CAST/Ei * BALB/cByJ MGI:3695309


Genotype
MGI:5696186
hm1
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic
Background		 CBA.Cg-Atp2b2dfw-2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired swimming ( J:220660 )
• cannot stay afloat in water




Genotype
MGI:3580890
hm2
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2dfw-2J
Genetic
Background		 CByJ.A-Atp2b2dfw-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:38429 )
• no discernible auditory brainstem responses (ABR) to stimuli up to 100 dB
deafness ( J:38429 )
• profoundly deaf
• complete deafness at 3 weeks after birth
absent linear vestibular evoked potential ( J:116914 )
• VESPs are absent at the maximum stimulus intensity used

behavior/neurological
lethargy ( J:38429 )
• becomes increasingly lethargic
abnormal reflex ( J:116914 )
• abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior
tremors ( J:38429 )
• a slight body tremor
ataxia ( J:38429 )
• highly unbalanced and uncontrolled movements starting by 12-14 days of age
impaired swimming ( J:116914 )
• mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface
abnormal gait ( J:38429 )
• walk with a hesitant and wobbly gait

reproductive system
infertility ( J:38429 )
• life span is normal, but neither sex breeds




Genotype
MGI:5696187
ht3
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2+
Genetic
Background		 CBA.Cg-Atp2b2dfw-2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:220660 )
N
• behave as well as controls in swimming and rotarod tests when tested at 33 days of age




Genotype
MGI:3580891
ht4
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2+
Genetic
Background		 CByJ.A-Atp2b2dfw-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:38429 )
• at 4 to 5 weeks of age, significantly elevated sound pressure thresholds
increased susceptibility to age-related hearing loss ( J:38429 )
• hearing loss begins 4 weeks after birth and progresses rapidly to complete deafness by 12 weeks of age
deafness ( J:38429 )
• show age-dependent hearing loss by 12 weeks of age
reduced linear vestibular evoked potential ( J:116914 )
• elevated threshold and reduced amplitudes




Genotype
MGI:4436907
ht5
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2+
Genetic
Background		 involves: CAST/Ei * BALB/cByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:38429 , J:70964 )
N
• in a mapping cross heterozygosity for deaf waddler 2 Jackson is found to have normal hearing when the age related hearing loss allele is absent proving this to be the recessive deafness-enhancing modifier, which is absent in CAST/Ei (J:38429)
(J:70964)




Genotype
MGI:3695310
cx6
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2+
Cdh23ahl/Cdh23ahl
Genetic
Background		 involves: BALB/cByJ * MOLF
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
Cdh23ahl mutation (55 available); any Cdh23 mutation (281 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:38429 )
• at 4 to 6 weeks of age, significantly elevated sound pressure thresholds
deafness ( J:38429 )
• show age-dependent hearing loss by 12 weeks of age




Genotype
MGI:3695309
cx7
Allelic
Composition		 Atp2b2dfw-2J/Atp2b2+
Cdh23ahl/Cdh23ahl
Genetic
Background		 involves: CAST/Ei * BALB/cByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2dfw-2J mutation (1 available); any Atp2b2 mutation (66 available)
Cdh23ahl mutation (55 available); any Cdh23 mutation (281 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:38429 )
• at 4 to 6 weeks of age, significantly elevated sound pressure thresholds
deafness ( J:38429 )
• show age-dependent hearing loss by 12 weeks of age




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory