Phenotypes associated with this allele

• Allele Symbol: Adcy1^brl
• Allele Name: barrelless
• Allele ID: MGI:1857405
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy1^brl/Adcy1^brl	B6.Cg-Adcy1^brl	MGI:3623029
hm2	Adcy1^brl/Adcy1^brl	involves: C57BL/6	MGI:3623019

Genotype
MGI:3623029

hm1

• Allelic Composition: Adcy1^brl/Adcy1^brl
• Genetic Background: B6.Cg-Adcy1^brl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:106269 )

• in mutants, paired stimuli produces less paired-pulse depression than in wild-type; paired-pulse ratios are increased in mutants compared to wild-type

abnormal excitatory postsynaptic currents ( J:106269 )

• in thalamocortical synapses, attenuation of NMDAR-mediated EPSCs by MK801 in mutants is much slower than in wild-type during repetitive stimulation with residual response detected after 40 minutes

Genotype
MGI:3623019

hm2

• Allelic Composition: Adcy1^brl/Adcy1^brl
• Genetic Background: involves: C57BL/6

nervous system

absent barrels in primary somatosensory cortex ( J:32194 )

• the primary somatosensory cortex is not parcellated into barrels

disorganized barrel cortex ( J:32194 )

• thalamocortical axons in mutants are terminated in layers IV and VI, but are continuously distributed in layer IV instead of being confined to barrels as in wild-type

abnormal somatosensory cortex physiology ( J:32194 )

• in mutant mice, response magnitudes to surround whiskers were larger than in wild-type; responses to the center whisker did not differ in latency from those to the surround whiskers unlike wild-type which show a greater latency for the surround whiskers