Phenotypes associated with this allele

• Allele Symbol: Esrrb^tm1Vgi
• Allele Name: targeted mutation 1, Vincent Giguere
• Allele ID: MGI:1857422
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esrrb^tm1Vgi/Esrrb^tm1Vgi	involves: 129S1/Sv * 129X1/SvJ	MGI:2166498

Genotype
MGI:2166498

hm1

• Allelic Composition: Esrrb^tm1Vgi/Esrrb^tm1Vgi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:42488 )

• no viable homozygotes later than E10.5 when no heart beat can be detected and embryos are undergoing resorption

growth/size/body

embryonic growth retardation ( J:42488 )

• growth retarded at E7.5 but appear normal at E6.5

decreased embryo size ( J:42488 )

• embryos small at E9.5 but normal at E6.5

embryo

embryonic growth retardation ( J:42488 )

• growth retarded at E7.5 but appear normal at E6.5

decreased embryo size ( J:42488 )

• embryos small at E9.5 but normal at E6.5

disorganized embryonic tissue ( J:42488 )

• tendancy for internal structures of embryo to be disorganized at E9.5

abnormal extraembryonic tissue morphology ( J:42488 )

abnormal chorion morphology ( J:42488 )

• absent or hypoplastic at E7.5

absent chorion ( J:42488 )

• chorion may be absent at E7.5

abnormal placenta morphology ( J:42488 )

absent placental labyrinth ( J:42488 )

• no labyrinthine trophoblast

abnormal trophoblast layer morphology ( J:42488 )

• multiple layers of giant cells found in the placenta at E9.5

abnormal trophoblast giant cell morphology ( J:42488 )

• marked increase in secondary giant cells at E8.5

decreased trophoblast giant cell number ( J:42488 )

• near absence of diploid trophoblast cells at E8.5

absent spongiotrophoblast ( J:42488 )

• absent

failure of chorioallantoic fusion ( J:42488 )

• failed fusion at E9.5