All Phenotypes Bax<tm1Sjk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bax^tm1Sjk
targeted mutation 1, Stanley J Korsmeyer
MGI:1857429

Summary

43 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bax^tm1Sjk/Bax^tm1Sjk	B6.129X1-Bax^tm1Sjk/J	MGI:3612870
hm2	Bax^tm1Sjk/Bax^tm1Sjk	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3716105
hm3	Bax^tm1Sjk/Bax^tm1Sjk	involves: 129X1/SvJ	MGI:2664866
hm4	Bax^tm1Sjk/Bax^tm1Sjk	involves: 129X1/SvJ * C57BL/6	MGI:3720887
ht5	Bax^tm1Sjk/Bax⁺	involves: 129X1/SvJ	MGI:3839355
cn6	Bax^tm1Sjk/Bax^tm1Sjk Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6 * DBA/2 * ICR	MGI:3811313
cn7	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3608659
cn8	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3608663
cn9	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Kras^tm4Tyj/Kras⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5559061
cn10	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)#Mam/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB	MGI:3819938
cn11	Bax^tm1Sjk/Bax^tm1Sjk Pcdhg^tm2Xzw/Pcdhg^tm2Xzw Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * SJL	MGI:3821864
cn12	Bax^tm1Sjk/Bax^tm1Sjk Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459062
cx13	Bax^tm1Sjk/Bax^tm1Sjk Lama2^tm1Eeng/Lama2^tm1Eeng	B6.129-Bax^tm1Sjk Lama2^tm1Eeng	MGI:3789336
cx14	Bax^tm1Sjk/Bax^tm1Sjk Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast	B6.129-Bcl2l11^tm1.1Ast Bax^tm1Sjk	MGI:3612872
cx15	Bax^tm1Sjk/Bax^tm1Sjk Col25a1^tm1.1Tiwa/Col25a1^tm1.1Tiwa	B6.Cg-Col25a1^tm1.1Tiwa Bax^tm1Sjk	MGI:5781124
cx16	Bax^tm1Sjk/Bax^tm1Sjk Col25a1^tm1.1Tiwa/Col25a1⁺	B6.Cg-Col25a1^tm1.1Tiwa Bax^tm1Sjk	MGI:5781125
cx17	Bax^tm1Sjk/Bax^tm1Sjk Hax1^tm1Jni/Hax1^tm1Jni	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3777920
cx18	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6	MGI:2656014
cx19	Bax^tm1Sjk/Bax^tm1Sjk Chn1^tm1.1Ece/Chn1^tm1.1Ece Tg(Hlxb9-GFP)1Tmj/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:6406403
cx20	Bax^tm1Sjk/Bax^tm1Sjk Ntrk1^tm1Apat/Ntrk1^tm1Apat	involves: 129S1/Sv * 129X1/SvJ	MGI:4413457
cx21	Bax^tm1Sjk/Bax^tm1Sjk Etv1^tm2Tmj/Etv1^tm2Tmj	involves: 129S1/Sv * 129X1/SvJ	MGI:5506523
cx22	Bax^tm1Sjk/Bax^tm1Sjk Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}	involves: 129S1/Sv * 129X1/SvJ	MGI:3052170
cx23	Bax^tm1Sjk/Bax⁺ Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3778827
cx24	Bax^tm1Sjk/Bax^tm1Sjk Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3778828
cx25	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk	involves: 129S1/Sv * 129X1/SvJ	MGI:3819936
cx26	Bax^tm1Sjk/Bax^tm1Sjk Wnt4^tm1Amc/Wnt4^{tm3(EGFP/cre)Amc}	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5545922
cx27	Bax^tm1Sjk/Bax^tm1Sjk Gdnf^tm1Rosl/Gdnf⁺	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3588576
cx28	Bax^tm1Sjk/Bax^tm1Sjk Ntf3^tm1Jae/Ntf3^tm1Jae	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:3720886
cx29	Bax^tm1Sjk/Bax^tm1Sjk Pcdhg^tm1.1Tman/Pcdhg^tm1.1Tman	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5440874
cx30	Bax^tm1Sjk/Bax^tm1Sjk Islr2^tm1.1Ddg/Islr2^tm1.1Ddg	involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:4413455
cx31	Bax^tm1Sjk/Bax⁺ Bcl2l1^tm1Mam/Bcl2l1^tm1Mam	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:2176704
cx32	Bax^tm1Sjk/Bax^tm1Sjk Bcl2l1^tm1Mam/Bcl2l1^tm1Mam	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:2662433
cx33	Bax^tm1Sjk/Bax^tm1Sjk Sp9^tm1.1Zyan/Sp9^tm1.1Zyan	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:6161737
cx34	Cbln1^tm1Jim/Cbln1^tm1Jim Bax^tm1Sjk/Bax^tm1Sjk	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:5316023
cx35	Bax^tm1Sjk/Bax^tm1Sjk Ngf^tm1Gne/Ngf^tm1Gne	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:4413456
cx36	Bax^tm1Sjk/Bax^tm1Sjk Del(18Pcdhg)1Xzw/Del(18Pcdhg)1Xzw	involves: 129X1/SvJ	MGI:5440876
cx37	Bax^tm1Sjk/Bax^tm1Sjk Grid2^Lc-J/Grid2⁺	involves: 129X1/SvJ * BALB/cByJ * C57BL/6	MGI:4360653
cx38	Bax^tm1Sjk/Bax⁺ Grid2^Lc-J/Grid2⁺	involves: 129X1/SvJ * BALB/cByJ * C57BL/6	MGI:4360655
cx39	Bax^tm1Sjk/Bax⁺ Kitl^Sl/Kitl^Sl Tg(Pou5f1-GFP)1Scho/?	involves: 129X1/SvJ * C3H * CD-1 * FVB	MGI:3693198
cx40	Bax^tm1Sjk/Bax^tm1Sjk Kitl^Sl/Kitl^Sl Tg(Pou5f1-GFP)1Scho/?	involves: 129X1/SvJ * C3H * CD-1 * FVB	MGI:3693197
cx41	Bax^tm1Sjk/Bax^tm1Sjk Ror2^Y324C/Ror2^Y324C	involves: 129X1/SvJ * C57BL/6J	MGI:5305092
cx42	Bax^tm1Sjk/Bax^tm1Sjk Tg(Ins2-Mirc13)E4Biat/0	involves: 129X1/SvJ * C57BL/6N	MGI:6829609
cx43	Bax^tm1Sjk/Bax^tm1Sjk Tg(SOD1*G93A)1Gur/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:4835659

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	B6.129X1-Bax^tm1Sjk/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:103605 )

arrest of male meiosis ( J:103605 )

• arrests before the completion of meiosis in the preleptotene spermatocyte stage

reproductive system

abnormal seminiferous tubule morphology ( J:103605 )

• some tubules have an accumulation of early germ cells while others have fewer germ cells than normal

• the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick

decreased testis weight ( J:103605 )

• in adults testes weigh about 60% that of wild-type

abnormal spermatogenesis ( J:103605 )

• at P15 the number of germ cells in the testis is increased and these are mostly c-Kit+ early germ cells, but in adult males the number of germ cells is decreased by up to 10-fold compared to wild-type

azoospermia ( J:103605 )

arrest of male meiosis ( J:103605 )

• arrests before the completion of meiosis in the preleptotene spermatocyte stage

male infertility ( J:103605 )

• males but not females are sterile

growth/size/body

decreased body weight ( J:103605 )

• seen in about 50% of mice

nervous system

nervous system phenotype ( J:122607 )

N	• cultured enteric neurons from Bax-deficient embryos that are GDNF-deprived show no significant differences in survival relative to enteric neurons from conditionally-inactivated Gfra1-null mice

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:103605 )

• some tubules have an accumulation of early germ cells while others have fewer germ cells than normal

• the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick

decreased testis weight ( J:103605 )

• in adults testes weigh about 60% that of wild-type

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:100886 )

• neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

increased sensory neuron number ( J:100886 )

• apoptosis rates are decreased resulting in increased number of neurons in the lumbar dorsal root ganglia (170% of wild-type numbers)

abnormal dorsal root ganglion morphology ( J:100886 )

• dorsal root ganglia neurons survive without neurotrophic factors

cellular

abnormal axon extension ( J:100886 )

• neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged spleen ( J:29253 )

endocrine/exocrine glands

increased thymocyte number ( J:29253 )

• 1.6 fold increase in thymocyte number relative to wild-type

• normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

increased atretic ovarian follicle number ( J:29253 )

• numerous atretic follicles with excess residual granulosa cells

abnormal seminiferous tubule morphology ( J:29253 )

• disordered

hematopoietic system

increased thymocyte number ( J:29253 )

• 1.6 fold increase in thymocyte number relative to wild-type

• normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

enlarged spleen ( J:29253 )

increased B cell number ( J:29253 )

immune system

increased thymocyte number ( J:29253 )

• 1.6 fold increase in thymocyte number relative to wild-type

• normal distribution of maturational subsets (CD4-CD8-, CD4+CD8+, CD4+, CD8+ cells)

enlarged spleen ( J:29253 )

increased B cell number ( J:29253 )

reproductive system

azoospermia ( J:29253 )

• absence of sperm in the epididymis and vas deferens

increased male germ cell apoptosis ( J:29253 )

increased atretic ovarian follicle number ( J:29253 )

• numerous atretic follicles with excess residual granulosa cells

abnormal seminiferous tubule morphology ( J:29253 )

• disordered

arrest of spermatogenesis ( J:29253 )

• accumulation of premeiotic germ cells

male infertility ( J:29253 )

nervous system

nervous system phenotype ( J:192549 )

N	• mice exhibit normal mammary gland innervation

decreased neuron apoptosis ( J:35372 )

• developmental sympathetic and motor neuronal death is reduced

abnormal superior cervical ganglion morphology ( J:35372 )

• superior cervical ganglion of neonates contains 2.5 and 1.8 times more neurons than wild-type and heterozygous ganglia, respectively

abnormal sympathetic neuron morphology ( J:35372 )

• sympathetic neurons from superior cervical ganglion show a dramatic reduction of death after trophic factor (NGF) deprivation

abnormal facial motor nucleus morphology ( J:35372 )

• mutants exhibit a large reduction in motor neuron death in the facial nucleus following neonatal axotomy compared to wild-type

increased motor neuron number ( J:35372 )

• contralateral nonaxotomized facial nucleus shows a 51% increase in neuronal number relative to wild-type at 4 weeks of age

• mutants display an increase in the number of small- to medium-sized motor neurons

increased sensory neuron number ( J:197913 )

• number of proprioceptive sensory neurons (pSNs) is increased by 2-fold compared to wild-type controls

abnormal proprioceptive neuron morphology ( J:197913 )

• about 30% of pSNs in the rostral lumbar DRG have cell body diameters in the wild-type range, with 70% having smaller somatic diameters

abnormal phrenic nerve morphology ( J:91066 )

• the phrenic nerve is thicker in mutants, however neuromuscular synapses were normal

cellular

azoospermia ( J:29253 )

• absence of sperm in the epididymis and vas deferens

increased male germ cell apoptosis ( J:29253 )

decreased neuron apoptosis ( J:35372 )

• developmental sympathetic and motor neuronal death is reduced

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mature ovarian follicle number ( J:52574 )

• increased number of follicles observed at 42 days of age

• persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

abnormal ovarian folliculogenesis ( J:52574 )

• reduced incidence of atresia of primordial and primary follicles relative to wild-type

• increased number of follicles observed at 42 days

• follicles persisted in aged females (20 to 22 months old)

nervous system

abnormal dorsal root ganglion morphology ( J:83461 )

• the number of dorsal root ganglia neurons in L4 is increased relative to in wild-type mice

reproductive system

increased mature ovarian follicle number ( J:52574 )

• increased number of follicles observed at 42 days of age

• persistence of hundreds of follicles of all developmental stages in aged females (20 to 22 months old)

abnormal ovarian folliculogenesis ( J:52574 )

• reduced incidence of atresia of primordial and primary follicles relative to wild-type

• increased number of follicles observed at 42 days

• follicles persisted in aged females (20 to 22 months old)

uterus hypertrophy ( J:52574 )

• ovarian steroid-driven uternine hypertrophy is observed in aged females (20 to 22 months old)

Allelic Composition	Bax^tm1Sjk/Bax⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sympathetic neuron morphology ( J:35372 )

• cultures of sympathetic neurons grown in the presence of NGF before being deprived of NGF, die with slower kinetics than wild-type, such that after 8 days, 14% of neurons remain viable compared to none in controls

increased motor neuron number ( J:35372 )

• modest 13% increase in the total number of facial motor neurons at 4 weeks of age relative to wild-type

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (90 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung development ( J:106392 )

• while increased apoptosis of epithelial cells is rescued, mice exhibit abnormal branching morphogenesis

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:100463 )

• 4-fold increase in the number of CD43⁺IgM^- Pro-B cells

abnormal B cell number ( J:100463 )

decreased marginal zone B cell number ( J:100463 )

• relative number of CD21^highCD23^low marginal zone B cells is decreased

increased B cell number ( J:100463 )

• increase in the number of B cells at all stages of development in the bone marrow and spleen

increased transitional stage B cell number ( J:100463 )

• a 3-5 fold increase in the numbers of transitional B cells

increased B-2 B cell number ( J:100463 )

• an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity

increased follicular B cell number ( J:100463 )

• an increase in CD21^intCD23^high follicular B cells

increased pre-B cell number ( J:100463 )

• a 4-fold increase in the number of IgM⁺ immature B cells

abnormal B cell physiology ( J:100463 )

• B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage

• cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA

increased immunoglobulin level ( J:100463 )

• all isotypes were 5-10 times higher than controls

increased IgA level ( J:100463 )

increased IgG level ( J:100463 )

• increased IgG1, IgG2, IgG2b and IgG3

increased IgM level ( J:100463 )

hematopoietic system

increased pro-B cell number ( J:100463 )

• 4-fold increase in the number of CD43⁺IgM^- Pro-B cells

increased bone marrow cell number ( J:100463 )

• 2-fold increase in total cellularity of bone marrow cells, due to accumulation of developing B cells

abnormal B cell number ( J:100463 )

decreased marginal zone B cell number ( J:100463 )

• relative number of CD21^highCD23^low marginal zone B cells is decreased

increased B cell number ( J:100463 )

• increase in the number of B cells at all stages of development in the bone marrow and spleen

increased transitional stage B cell number ( J:100463 )

• a 3-5 fold increase in the numbers of transitional B cells

increased B-2 B cell number ( J:100463 )

• an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity

increased follicular B cell number ( J:100463 )

• an increase in CD21^intCD23^high follicular B cells

increased pre-B cell number ( J:100463 )

• a 4-fold increase in the number of IgM⁺ immature B cells

abnormal B cell physiology ( J:100463 )

• B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage

• cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA

increased immunoglobulin level ( J:100463 )

• all isotypes were 5-10 times higher than controls

increased IgA level ( J:100463 )

increased IgG level ( J:100463 )

• increased IgG1, IgG2, IgG2b and IgG3

increased IgM level ( J:100463 )

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:100463 )

• by 35 weeks after induction of Cre expression (and thus Bax deletion) in the adult, 78% of mutants die compared to 5% of wild-type

immune system

abnormal T cell differentiation ( J:100463 )

• thymic T cell development is perturbed after poly(I:C) injection

increased leukocyte cell number ( J:100463 )

• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult

increased lymphocyte cell number ( J:100463 )

increased B cell number ( J:100463 )

• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

increased susceptibility to autoimmune disorder ( J:100463 )

• develop autoimmune disease after poly(I:C) injection to induce Bax deletion in the adult

increased anti-double stranded DNA antibody level ( J:100463 )

• show elevated serum antinuclear antibodies and anti-dsDNA antibody after 30 weeks of poly(I:C) injection to induce Bax deletion in the adult

autoimmune arthritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

glomerulonephritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

hematopoietic system

abnormal T cell differentiation ( J:100463 )

• thymic T cell development is perturbed after poly(I:C) injection

increased leukocyte cell number ( J:100463 )

• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult

increased lymphocyte cell number ( J:100463 )

increased B cell number ( J:100463 )

• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

renal/urinary system

glomerulonephritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

skeleton

autoimmune arthritis ( J:100463 )

• develops after poly(I:C) injection to induce Bax deletion in the adult

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Kras^tm4Tyj/Kras⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased adenocarcinoma incidence ( J:125101 )

• intranasal instillation of an adenovirus expressing Cre recombinase (Ad-Cre) results in the development of sinonasal adenocarcinomas

• however, mice injected intramuscularly with Ad-Cre into the extremities or uterus do not develop soft tissue sarcomas

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm2Sjk Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)#Mam/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (25 available)
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bax^tm2Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1^tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(MMTV-cre)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:141545 )

N	• unlike in Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam Tg(MMTV-cre)Mam mice or Bnip3l^tm1Ney homozygotes, spleen size, red blood cell numbers and reticulocytes clear of mitochondria are normal

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Pcdhg^tm2Xzw/Pcdhg^tm2Xzw Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Pcdhg^tm2Xzw mutation (1 available); any Pcdhg mutation (13 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:142186 )

N	• mice exhibit normal inner nuclear, inner plexiform and ganglion cell layer thickness and numbers of bipolar cells

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ret^tm1Heno/Ret^{tm3.1(Bcl2l1)Heno} Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ret^tm1Heno mutation (0 available); any Ret mutation (54 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:159854 )

• tamoxifen-treated mice exhibit loss of enteric neurons unlike similarly treated control mice (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Lama2^tm1Eeng/Lama2^tm1Eeng
Genetic Background	B6.129-Bax^tm1Sjk Lama2^tm1Eeng

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Lama2^tm1Eeng mutation (2 available); any Lama2 mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:94431 )

• early death found in Lama2 mutant homozygotes is prevented by the homozygous presence of the Bax disruption, survival exceeds 120 days

muscle

abnormal skeletal muscle fiber morphology ( J:94431 )

increased skeletal muscle mass ( J:94431 )

• individual muscles are larger, in both mass and cross-sectional area, and have more myofibers than those wild-type for Bax

impaired skeletal muscle regeneration ( J:94431 )

• the abnormal muscle regeneration of Lama2 mutants is not rescued by the Bax disruption

growth/size/body

abnormal postnatal growth/weight/body size ( J:94431 )

• inactivation of Bax results in increased weight gain and growth relative to Bax wild-type Lama2 mutants, but inactivation of Bax does not entirely rescue Lama2 mutants from diminished weight gain and growth

decreased body size ( J:94431 )

decreased body weight ( J:94431 )

behavior/neurological

behavior/neurological phenotype ( J:94431 )

N	• the hindlimb fixed contractures found in Lama2 mutants are prevented by the disruption of Bax such that even at 6 months of age the hindlimbs, although weaker than in wild-type, are not paralyzed and there is normal exploratory standing behavior

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast
Genetic Background	B6.129-Bcl2l11^tm1.1Ast Bax^tm1Sjk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l11^tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:103605 )

arrest of male meiosis ( J:103605 )

• arrests before the completion of meiosis in the preleptotene spermatocyte stage identical to Bax^tm1Sjk homozygotes

abnormal seminiferous tubule epithelium morphology ( J:103605 )

• the epithelium is grossly dysmorphic

small seminiferous tubules ( J:103605 )

• tubule diameter is decreased and no spermatids are seen

male infertility ( J:103605 )

• males but not females are sterile

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:103605 )

• the epithelium is grossly dysmorphic

small seminiferous tubules ( J:103605 )

• tubule diameter is decreased and no spermatids are seen

cellular

azoospermia ( J:103605 )

arrest of male meiosis ( J:103605 )

• arrests before the completion of meiosis in the preleptotene spermatocyte stage identical to Bax^tm1Sjk homozygotes

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Col25a1^tm1.1Tiwa/Col25a1^tm1.1Tiwa
Genetic Background	B6.Cg-Col25a1^tm1.1Tiwa Bax^tm1Sjk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Col25a1^tm1.1Tiwa mutation (0 available); any Col25a1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal phrenic nerve innervation pattern to diaphragm ( J:206855 )

• at E14.5, motor neuron projections reach the diaphragm but fail to innervate the muscle fibers unlike in wild-type mice

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Col25a1^tm1.1Tiwa/Col25a1⁺
Genetic Background	B6.Cg-Col25a1^tm1.1Tiwa Bax^tm1Sjk

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal phrenic nerve morphology ( J:206855 )

• slightly larger diameter than in wild-type mice at E14.5

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Hax1^tm1Jni/Hax1^tm1Jni
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Hax1^tm1Jni mutation (0 available); any Hax1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:132627 )

• survival reduced relative to controls but improved relative to Hax1^tm1Jni single homozygous mice

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:66872 )

• majority die within 48 hours of birth, although some survive to adulthood

limbs/digits/tail

interdigital webbing ( J:66872 )

• mutants retain interdigital webs on both fore and rear paws

reproductive system

vagina atresia ( J:66872 )

• seen in all adult females

behavior/neurological

circling ( J:66872 )

• display circling behavior when exposed to external stress

seizures ( J:66872 )

• stress-induced seizure activity

hearing/vestibular/ear

abnormal hearing physiology ( J:66872 )

• unresponsive to auditory stimuli

hematopoietic system

enlarged spleen ( J:66872 )

abnormal definitive hematopoiesis ( J:66872 )

• hematopoietic colony assays show an increase in the number of myeloid colony forming units and a mild increase in erythroid and megakaryocyte colony forming units

anemia ( J:66872 )

• mild anemia

thrombocytopenia ( J:66872 )

increased leukocyte cell number ( J:66872 )

increased lymphocyte cell number ( J:66872 )

• increases within the circulation and the peripheral lymphoid organs

• lymphocytic infiltration is seen in parenchymal organs, liver, and kidney

abnormal B cell morphology ( J:66872 )

• B220+ B cells present in the lymph node and spleen are skewed toward a B220^brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells

abnormal T cell morphology ( J:66872 )

• T cells that accumulate in mutants are skewed toward a memory cell phenotype

increased spleen red pulp amount ( J:66872 )

• expanded red pulp contains a large increase in the number of plasma cells and histiocytes

increased spleen white pulp amount ( J:66872 )

• pronounced hyperplasia

abnormal splenocyte physiology ( J:66872 )

• isolated splenocytes cultured in suspension show enhanced survival

immune system

enlarged spleen ( J:66872 )

increased leukocyte cell number ( J:66872 )

increased lymphocyte cell number ( J:66872 )

• increases within the circulation and the peripheral lymphoid organs

• lymphocytic infiltration is seen in parenchymal organs, liver, and kidney

abnormal B cell morphology ( J:66872 )

• B220+ B cells present in the lymph node and spleen are skewed toward a B220^brightIgD- phenotype, indicating an increase in the number of class-switched or memory B cells

abnormal T cell morphology ( J:66872 )

• T cells that accumulate in mutants are skewed toward a memory cell phenotype

increased spleen red pulp amount ( J:66872 )

• expanded red pulp contains a large increase in the number of plasma cells and histiocytes

increased spleen white pulp amount ( J:66872 )

• pronounced hyperplasia

abnormal splenocyte physiology ( J:66872 )

• isolated splenocytes cultured in suspension show enhanced survival

enlarged lymph nodes ( J:66872 )

nervous system

seizures ( J:66872 )

• stress-induced seizure activity

abnormal brain morphology ( J:66872 )

• increase in the number of neurons in multiple regions of the brain

• large accumulation of small neuronal cells (neural stem cells) with dense chromatin staining in the periventricular region

increased brain size ( J:66872 )

increased neuron number ( J:66872 )

• in multiple regions of the brain

cellular

decreased cellular sensitivity to gamma-irradiation ( J:66872 )

• thymocytes show enhanced survival compared to wild-type when exposed to gamma irradiation

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:66872 )

• thymocytes are resistant to treatment with etoposide, a chemotherapeutic agent that normally induces cell death

growth/size/body

enlarged spleen ( J:66872 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Chn1^tm1.1Ece/Chn1^tm1.1Ece Tg(Hlxb9-GFP)1Tmj/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Chn1^tm1.1Ece mutation (0 available); any Chn1 mutation (44 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation ( J:243785 )

• abducens nerve stalling to the lateral rectus is seen at E11.5 and E16.5 mutants lack abducens nerves in the orbital area

• E16.5 mutants show oculomotor misinnervation of the lateral rectus

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ntrk1^tm1Apat/Ntrk1^tm1Apat
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ntrk1^tm1Apat mutation (1 available); any Ntrk1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• E14.5, extension of hind limb nerves is defective compared to in wild-type mice

• extension of the lateral plantar nerve is reduced 9% compared to in wild-type mice

• at E15.5, the number and order of branches in the medial digital branch of the lateral plantar nerve in the fifth digit are impaired compared to in wild-type mice

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Etv1^tm2Tmj/Etv1^tm2Tmj
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Etv1^tm2Tmj mutation (0 available); any Etv1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased sensory neuron number ( J:197913 )

• number of proprioceptive sensory neurons (pSNs) is increased by 2-fold compared to wild-type controls

abnormal proprioceptive neuron morphology ( J:197913 )

• about 30% of pSNs in the rostral lumbar DRG have cell body diameters in the wild-type range, with 70% having smaller somatic diameters

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ntrk1^{tm2(Ntrk3)Apat} mutation (0 available); any Ntrk1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased muscle spindle number ( J:92099 )

• a 7-fold increase in the number of muscle spindles in the soleus muscle compared to Bax^tm1Sjk homozygotes

abnormal proprioceptive neuron morphology ( J:92099 )

• a 5-fold increase in the number of proprioceptive neurons in the soleus muscle compared to Bax^tm1Sjk homozygotes

muscle

increased muscle spindle number ( J:92099 )

• a 7-fold increase in the number of muscle spindles in the soleus muscle compared to Bax^tm1Sjk homozygotes

Allelic Composition	Bax^tm1Sjk/Bax⁺ Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

abnormal male germ cell apoptosis ( J:132711 )

cellular

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

abnormal male germ cell apoptosis ( J:132711 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:132711 )

• male gonocytes become feminized

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

• however, male germ cells do not undergo abnormal apoptosis

cellular

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

• however, male germ cells do not undergo abnormal apoptosis

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:141545 )

N	• unlike in Bnip3l^tm1Ney homozygotes, reticulocytes clearance of mitochondria is normal

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Wnt4^tm1Amc/Wnt4^{tm3(EGFP/cre)Amc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Wnt4^tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt4^{tm3(EGFP/cre)Amc} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal oogenesis ( J:203797 )

• germ cells are rescued in absence of Bax and are present throughout the ovary; however, pregranulosa cells at the anterior end still show aberrant differentiation at birth (P0)

cellular

abnormal oogenesis ( J:203797 )

• germ cells are rescued in absence of Bax and are present throughout the ovary; however, pregranulosa cells at the anterior end still show aberrant differentiation at birth (P0)

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Gdnf^tm1Rosl/Gdnf⁺
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:82456 )

• 32-33% and 43-48% reduction in submucosal and myenteric neurons, respectively, similar to that seen in single heterozygous Gdnf mutants

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ntf3^tm1Jae/Ntf3^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ntf3^tm1Jae mutation (2 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent muscle spindles ( J:83461 )

• no muscle spindles are found in the soleus muscle during development and at later stages

abnormal dorsal root ganglion morphology ( J:83461 )

• the number of dorsal root ganglia neurons in L4 is increased by 50% relative to in wild-type mice

• while proprioceptive neurons are retained, the somata is reduced by 70%

abnormal proprioceptive neuron morphology ( J:83461 )

• proprioceptive neurons fail to innervate their target muscles

• proprioceptive axons fail to extend into the ventral horn

muscle

absent muscle spindles ( J:83461 )

• no muscle spindles are found in the soleus muscle during development and at later stages

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Pcdhg^tm1.1Tman/Pcdhg^tm1.1Tman
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Pcdhg^tm1.1Tman mutation (0 available); any Pcdhg mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:188341 )

• some mice die at P0

• however, neonatal lethality is partially rescued

behavior/neurological

ataxia ( J:188341 )

• persistent in surviving mice

weakness ( J:188341 )

growth/size/body

decreased body size ( J:188341 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Islr2^tm1.1Ddg/Islr2^tm1.1Ddg
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• mice exhibit the same neuron defects observed in Islr2^tm1.1Ddg homozygotes

Allelic Composition	Bax^tm1Sjk/Bax⁺ Bcl2l1^tm1Mam/Bcl2l1^tm1Mam
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Bcl2l1^tm1Mam mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovarian folliculogenesis ( J:63161 )

• decreased number of ovarian follicles

reproductive system

decreased male germ cell number ( J:63161 )

• absence of spermatogonia

abnormal ovarian folliculogenesis ( J:63161 )

• decreased number of ovarian follicles

male infertility ( J:63161 )

cellular

decreased male germ cell number ( J:63161 )

• absence of spermatogonia

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Bcl2l1^tm1Mam/Bcl2l1^tm1Mam
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovarian folliculogenesis ( J:63161 )

• increased follicle counts relative to double heterozygous control at 1 day of age

abnormal spermatogenesis ( J:63161 )

• excessive numbers of spermatogonia and spermatocytes

• mature sperm are not produced

azoospermia ( J:63161 )

male infertility ( J:63161 )

endocrine/exocrine glands

abnormal ovarian folliculogenesis ( J:63161 )

• increased follicle counts relative to double heterozygous control at 1 day of age

cellular

azoospermia ( J:63161 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Sp9^tm1.1Zyan/Sp9^tm1.1Zyan
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Sp9^tm1.1Zyan mutation (0 available); any Sp9 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:238868 )

N	• striatal cell death seen in single mutant SP9 KO mice is nearly absent in the Sp9;Bax/ double mutants at P3

decreased striatum size ( J:238868 )

• at P15, mutant striatum is larger in double mutants than single SP9 KO mice, but smaller than wild-type controls

Allelic Composition	Cbln1^tm1Jim/Cbln1^tm1Jim Bax^tm1Sjk/Bax^tm1Sjk
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Cbln1^tm1Jim mutation (0 available); any Cbln1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:182277 )

N	• no pyknotic granule cells in the internal granule cell layer

behavior/neurological

ataxia ( J:182277 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ngf^tm1Gne/Ngf^tm1Gne
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ngf^tm1Gne mutation (1 available); any Ngf mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:154926 )

• at E14.5, extension of hind limb nerves is defective compared to in wild-type mice

• extension of the third digital branch of the deep peroneal nerve is reduced 27% compared to in wild-type mice

• extension of the lateral plantar nerve is reduced 13% compared to in wild-type mice

• at E15.5, the number and order of branches in the medial digital branch of the lateral plantar nerve in the fifth digit are impaired compared to in wild-type mice

abnormal sensory neuron innervation pattern ( J:170402 )

• mice exhibit excessive nociceptor axons in deep spinal cord layers compared with wild-type mice

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Del(18Pcdhg)1Xzw/Del(18Pcdhg)1Xzw
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Del(18Pcdhg)1Xzw mutation (0 available); any Del(18Pcdhg)1Xzw mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:188341 )

• no mice are recovered beyond P0

behavior/neurological

abnormal voluntary movement ( J:188341 )

• mice lack voluntary movement

• however, mice exhibit improved neurological function

nervous system

nervous system phenotype ( J:188341 )

N	• mice do not exhibit microgliosis or astrocytosis as in Del(18Pcdhg)1Xzw homozygotes

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Grid2^Lc-J/Grid2⁺
Genetic Background	involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Grid2^Lc-J mutation (1 available); any Grid2 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:62117 )

• a swaying ataxia is found in the third week of age, the same as in simple lurcher heterozygotes

nervous system

nervous system phenotype ( J:62117 )

N	• disruption of Bax rescues the granule cell death normally found in Lurcher mice such that these mice have a nearly normal, large cell-dense inner granule cell layer and normal lobular pattern of the cerebellar cortex

abnormal cerebellar Purkinje cell layer ( J:62117 )

abnormal Purkinje cell morphology ( J:62117 )

• at 30 days of age immunohistochemistry shows that the Purkinje cells are not aligned in a monolayer and have stunted, poorly developed dendritic trees that fail to reach the pial surface, similar to the morphology found in Bax wild-type lurcher heterozygotes

abnormal Purkinje cell dendrite morphology ( J:62117 )

decreased Purkinje cell number ( J:62117 )

• there are few Purkinje cells at the interface of the inner granule cell layer and molecular layer, and, although cell counts show that there are 15% of normal numbers at 30 days of age, which is significantly more than the 6% normal level found in Bax wild-type lurcher heterozygotes, by 300 days of age the double mutant mice have only 1% of normal Purkinje cell numbers

abnormal cerebellar granule layer morphology ( J:62117 )

• although there are fewer than normal granule cells per midsagittal cerebellar section, there are approximately 60% of normal numbers which is a significant increase over the Bax wild-type lurcher heterozygotes

Allelic Composition	Bax^tm1Sjk/Bax⁺ Grid2^Lc-J/Grid2⁺
Genetic Background	involves: 129X1/SvJ * BALB/cByJ * C57BL/6

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:62117 )

• a swaying ataxia is found in the third week of age, the same as in simple lurcher heterozygotes

nervous system

reduced cerebellar foliation ( J:62117 )

abnormal cerebellar Purkinje cell layer ( J:62117 )

• gaps in the Purkinje cell layer found by 15 days of age

decreased Purkinje cell number ( J:62117 )

abnormal cerebellar granule layer morphology ( J:62117 )

• much smaller internal granule cell layer as early as 15 days of age

decreased cerebellar granule cell number ( J:62117 )

Allelic Composition	Bax^tm1Sjk/Bax⁺ Kitl^Sl/Kitl^Sl Tg(Pou5f1-GFP)1Scho/?
Genetic Background	involves: 129X1/SvJ * C3H * CD-1 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Kitl^Sl mutation (3 available); any Kitl mutation (94 available)
Tg(Pou5f1-GFP)1Scho mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primordial germ cell proliferation ( J:115283 )

• increased apoptosis of primordial germ cells

• decreased germ cell proliferation

cellular

abnormal primordial germ cell proliferation ( J:115283 )

• increased apoptosis of primordial germ cells

• decreased germ cell proliferation

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Kitl^Sl/Kitl^Sl Tg(Pou5f1-GFP)1Scho/?
Genetic Background	involves: 129X1/SvJ * C3H * CD-1 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primordial germ cell migration ( J:115283 )

• defective germ cell migration out of the hindgut

abnormal primordial germ cell proliferation ( J:115283 )

• normal apoptosis of primordial germ cells

• decreased germ cell proliferation

cellular

abnormal primordial germ cell migration ( J:115283 )

• defective germ cell migration out of the hindgut

abnormal primordial germ cell proliferation ( J:115283 )

• normal apoptosis of primordial germ cells

• decreased germ cell proliferation

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Ror2^Y324C/Ror2^Y324C
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Ror2^Y324C mutation (0 available); any Ror2 mutation (125 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primordial germ cell morphology ( J:179805 )

decreased primordial germ cell number ( J:179805 )

• no increase in the number of gonadal PGCs is seen compared to mutant mice wild-type for Bax

abnormal primordial germ cell migration ( J:179805 )

• increase in the number of ectopic PGCs compared to mutant mice wild-type for Bax

cellular

abnormal primordial germ cell morphology ( J:179805 )

decreased primordial germ cell number ( J:179805 )

• no increase in the number of gonadal PGCs is seen compared to mutant mice wild-type for Bax

abnormal primordial germ cell migration ( J:179805 )

• increase in the number of ectopic PGCs compared to mutant mice wild-type for Bax

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Tg(Ins2-Mirc13)E4Biat/0
Genetic Background	involves: 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Ins2-Mirc13)E4Biat mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:314874 )

N	• mice exhibit normal beta cell mass unlike mice expressing the transgene alone

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:314874 )

N	• mice exhibit normal glucose serum levels after a 4 h fast unlike mice expressing the transgene alone

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Tg(SOD1*G93A)1Gur/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Tg(SOD1*G93A)1Gur mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:111890 )

• live 14.6% longer than Tg(SOD1*G93A)1Gur mice

behavior/neurological

impaired coordination ( J:111890 )

• delayed onset of motor decline

• maintain 11 rpm on the rotarod for a longer period of their lifespan than Tg(SOD1*G93A)1Gur mice

nervous system

gliosis ( J:111890 )

• delayed reactive gliosis (P100 vs P40, compared with Tg(SOD1*G93A)1Gur mice)

abnormal motor neuron morphology ( J:111890 )

• atrophic axons of the lumbar motoneurons (MNs)

• the number of Slc18a3 mRNA-expressing MNs is not reduced in the entire lumbar spinal cord at the end-stage, compared with age-matched Bax^tm1Sjk homozygous controls

• many small groups of unmyelinated axons wrapped in glial cell processes in the end-stage fourth lumbar ventral root (L4 VR)

• higher levels of partially innervated synapses in end-stage delayed accumulation of mutant SOD1 in MNs (P40 vs P30, compared with Tg(SOD1*G93A)1Gur mice)

• delayed accumulation of mutant SOD1 in MNs (P40 vs P30, compared with Tg(SOD1*G93A)1Gur mice)

abnormal motor neuron innervation pattern ( J:111890 )

• decreased rate of neuromuscular denervation

• more medial gastrocnemii (MGs) axons and innervated

• neuromuscular junctions (NMJs) than Tg(SOD1*G93A)1Gur mutants at postnatal day 100 (P100)

• reduction of innervated synapses in the MG at P45, delayed onset compared with Tg(SOD1*G93A)1Gur mice

• contain more fully innervated NMJs at subsequent ages than Tg(SOD1*G93A)1Gur mutants, until P120

decreased motor neuron number ( J:111890 )

• delayed loss of both distal and proximal myelinated axons

• reduction of myelinated axons in end-stage MG nerve and L4 VR

cellular

abnormal mitochondrial morphology ( J:111890 )

• presence of vacuolated mitochondria in the ventral spinal cord at P25

• massive vacuolization in the lumbar ventral spinal cord at P100

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