All Phenotypes Fshb<tm1Zuk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fshb^tm1Zuk/Fshb^tm1Zuk	either: 129S/SvEv or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2177556
hm2	Fshb^tm1Zuk/Fshb^tm1Zuk	involves: 129S7/SvEvBrd	MGI:2665040

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oligozoospermia ( J:38099 )

• 75% reduction of epididymal sperm count relative to wild-type

asthenozoospermia ( J:38099 )

• 40% reduction in the number of motile sperm relative to wild-type

endocrine/exocrine glands

absent corpus luteum ( J:38099 )

absent mature ovarian follicles ( J:38099 )

impaired ovarian folliculogenesis ( J:38099 )

• blocked prior to antral follicle formation

small ovary ( J:38099 )

small seminiferous tubules ( J:38099 )

small testis ( J:38099 )

• progressive reduction in size beginning at 14 days of age

• however, serum testosterone levels in males were similar to those of wild-type and the epididymides and seminal glands were of normal size

homeostasis/metabolism

increased circulating luteinizing hormone level ( J:38099 )

• elevated only in females

decreased circulating progesterone level ( J:38099 )

• 50% decrease relative to wild-type

decreased follicle stimulating hormone level ( J:38099 )

• FSH was undetected in the pituitary

decreased circulating follicle stimulating hormone level ( J:38099 )

• FSH was undetected in serum

reproductive system

oligozoospermia ( J:38099 )

• 75% reduction of epididymal sperm count relative to wild-type

asthenozoospermia ( J:38099 )

• 40% reduction in the number of motile sperm relative to wild-type

absent corpus luteum ( J:38099 )

absent mature ovarian follicles ( J:38099 )

impaired ovarian folliculogenesis ( J:38099 )

• blocked prior to antral follicle formation

small ovary ( J:38099 )

small seminiferous tubules ( J:38099 )

small testis ( J:38099 )

• progressive reduction in size beginning at 14 days of age

• however, serum testosterone levels in males were similar to those of wild-type and the epididymides and seminal glands were of normal size

small uterus ( J:38099 )

• markedly thinner than wild-type

abnormal estrous cycle ( J:38099 )

absent estrous cycle ( J:38099 )

female infertility ( J:38099 )

• females but not males are infertile

Allelic Composition	Fshb^tm1Zuk/Fshb^tm1Zuk
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fshb^tm1Zuk mutation (1 available); any Fshb mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:71932 )

• 30% decrease in the number of sertoli cells relative to wild-type

decreased testis weight ( J:71932 )

• 60% reduction in weight relative to wild-type

reproductive system

abnormal spermatogonia morphology ( J:71932 )

• 46% reduction in spermatogonia

decreased male germ cell number ( J:71932 )

• decline in germ cell numbers that becomes more marked as spermatogenesis progresses; 46% reduction in A and I spermatogonia and a 60% reduction in round spermatids

abnormal Sertoli cell morphology ( J:71932 )

• 30% decrease in the number of sertoli cells relative to wild-type

decreased testis weight ( J:71932 )

• 60% reduction in weight relative to wild-type

abnormal spermatogenesis ( J:71932 )

• lower Sertoli cell to round spermatid ratio

• decrease in the ratios of spermatogonia and early stages of the first meiotic prophase (preleptotene, leptotene, and zygotene) to the later stages of meiotic prophase (pachytene and diplotene) and of pachytene/diplotene spermatocyte to round round spermatids, indicating impaired spermatogenesis

abnormal spermatid morphology ( J:71932 )

• 60% reduction in round spermatids