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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grm5tm1Rod
targeted mutation 1, John C Roder
MGI:1857437
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grm5tm1Rod/Grm5tm1Rod B6.129-Grm5tm1Rod MGI:6315641
hm2
 		Grm5tm1Rod/Grm5tm1Rod B6.129-Grm5tm1Rod/J MGI:3625474
hm3
 		Grm5tm1Rod/Grm5tm1Rod involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2176768
ht4
 		Grm5tm1Rod/Grm5+ involves: 129 * C57BL/6 * FVB MGI:3767566
cx5
 		Fmr1tm1Cgr/Y
Grm5tm1Rod/Grm5+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:3767570


Genotype
MGI:6315641
hm1
Allelic
Composition		 Grm5tm1Rod/Grm5tm1Rod
Genetic
Background		 B6.129-Grm5tm1Rod
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation (2 available); any Grm5 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal associative learning ( J:268239 )
• mice exhibit impaired pairwise visual discrimination, requiring more trials to reach criterion, performing more correction trials, and increased preservation index
impaired learning ( J:268239 )
• mice are impaired on early reversal learning, taking more trials to reach criterion and requiring more correction trials overall and when adjusting for other factors and exhibit this similar phenotype on late reversal learning
• mice are impaired at extinction, responding at a higher rate throughout the extinction sessions
• mice show no differences in locomotor activity, reward collection time or latency to touch stimuli across reversal learning
impaired discrimination learning ( J:268239 )
• mice exhibit impaired pairwise visual discrimination, requiring more trials to reach criterion, performing more correction trials, and increased preservation index
• mice show no differences in locomotor activity, reward collection time or latency to touch stimuli across visual discrimination
cognitive inflexibility ( J:268239 )
• mice are impaired on early reversal learning, taking more trials to reach criterion and requiring more correction trials overall and when adjusting for other factors and exhibit this similar phenotype on late reversal learning
• mice are impaired at extinction, responding at a higher rate throughout the extinction sessions

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
 J:268239




Genotype
MGI:3625474
hm2
Allelic
Composition		 Grm5tm1Rod/Grm5tm1Rod
Genetic
Background		 B6.129-Grm5tm1Rod/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation (2 available); any Grm5 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor activation ( J:102700 )
• mutants do not show any locomotor stimulation in response to a Grm5, MPEP, antagonist whereas wild-type littermates display increased locomotor activity




Genotype
MGI:2176768
hm3
Allelic
Composition		 Grm5tm1Rod/Grm5tm1Rod
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation (2 available); any Grm5 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic potential ( J:41096 )
• field excitatory postsynaptic potential (fEPSP) depression by (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) is attenuated (12+/-10% compared to 55.5+/-4.6% in wild-type mice at 50uM ACPD)
• however, fEPSP depression by ACPD at 300uM is normal
reduced long-term potentiation ( J:41096 )
• significant reduction in long term depression (LTP) in NMDA receptor-dependent pathways, such as the CA1 region and dentate gyrus of the hippocampus, but not in NMDA receptor-independent pathways, such as the mossy fiber synapses of the CA3 region
• LTP in the last 30 minutes after tetanus was 50.2+/-5.7% above baseline compared to 77.6+/-10.2% above base line in wild-type mice

behavior/neurological
abnormal contextual conditioning behavior ( J:41096 )
• mice exhibit a decrease in contextual fear conditioning
abnormal spatial learning ( J:41096 )
• mice exhibit decreased learning acquisition in a hidden platform water maze
• in a water maze, mice spend less time searching for the target quadrant and cross the platform less frequently when compared with wild-type mice
• however, locomotion and performance in an open field test are normal




Genotype
MGI:3767566
ht4
Allelic
Composition		 Grm5tm1Rod/Grm5+
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation (2 available); any Grm5 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nerve fiber response ( J:127792 )
• deprived-eye depression is reduced following monocular depression in comparison to controls




Genotype
MGI:3767570
cx5
Allelic
Composition		 Fmr1tm1Cgr/Y
Grm5tm1Rod/Grm5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1Cgr mutation (5 available); any Fmr1 mutation (29 available)
Grm5tm1Rod mutation (2 available); any Grm5 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:127792 )
N
• latency to enter box following the inhibitory avoidance test is similar to wildtype, but significantly different from mice of the genotype Fmr1tm1Cgr/Y
audiogenic seizures ( J:127792 )
• 33.3% of mice have a seizure in response to the test tone

nervous system
nervous system phenotype ( J:127792 )
N
• visually evoked potentials are similar to wildtype control
• dendritic spine density is similar to wildtype control, but less than Fmr1tm1Cgr/Y mice
audiogenic seizures ( J:127792 )
• 33.3% of mice have a seizure in response to the test tone

growth/size/body
growth/size/body region phenotype ( J:127792 )
N
• adult body weight is similar to wild-type, but less than Fmr1tm1Cgr/Y mice

endocrine/exocrine glands
increased testis weight ( J:127792 )
• increase is only observed in adult (11-12 weeks)

reproductive system
increased testis weight ( J:127792 )
• increase is only observed in adult (11-12 weeks)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory