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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il12rb1tm1Jm
targeted mutation 1, Jeanne Magram
MGI:1857440
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il12rb1tm1Jm/Il12rb1tm1Jm involves: 129S1/Sv * C57BL/6J MGI:2179434
cx2
 		Il12rb1tm1Jm/Il12rb1tm1Jm
Tg(Rorc-EGFP)1Ebe/? 		involves: 129S1/Sv * C57BL/6 MGI:3829419


Genotype
MGI:2179434
hm1
Allelic
Composition		 Il12rb1tm1Jm/Il12rb1tm1Jm
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12rb1tm1Jm mutation (2 available); any Il12rb1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte physiology ( J:42105 )
• Con A-activated splenocytes fail to proliferate in response to IL12 at concentrations as high as 67 nM but proliferate as well as wild-type cells in response to IL2 and IL7
decreased circulating interferon-gamma level ( J:42105 )
• IFNG is undetectable in sera from recombinant IL12-treated mice and very low in endotoxin LPS-treated mice, unlike in wild-type mice
decreased interferon-gamma secretion ( J:42105 )
• absence of IL12-stimulated Ifng production in Con A-activated splenocytes
• splenocytes are profoundly impaired in production of IFNG in response to anti-CD antibody or Con A

homeostasis/metabolism
decreased circulating interferon-gamma level ( J:42105 )
• IFNG is undetectable in sera from recombinant IL12-treated mice and very low in endotoxin LPS-treated mice, unlike in wild-type mice

hematopoietic system
abnormal lymphocyte physiology ( J:42105 )
• Con A-activated splenocytes fail to proliferate in response to IL12 at concentrations as high as 67 nM but proliferate as well as wild-type cells in response to IL2 and IL7




Genotype
MGI:3829419
cx2
Allelic
Composition		 Il12rb1tm1Jm/Il12rb1tm1Jm
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12rb1tm1Jm mutation (2 available); any Il12rb1 mutation (33 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased

immune system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory