About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il1r1tm1Roml
targeted mutation 1, Mark A Labow
MGI:1857441
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il1r1tm1Roml/Il1r1tm1Roml C.Cg-Il1r1tm1Roml MGI:3622351
hm2
Il1r1tm1Roml/Il1r1tm1Roml involves: 129S1/Sv MGI:3762043
hm3
Il1r1tm1Roml/Il1r1tm1Roml involves: 129S1/Sv * BALB/c MGI:3721963
hm4
Il1r1tm1Roml/Il1r1tm1Roml involves: 129S1/Sv * C57BL/6 MGI:2179490
hm5
Il1r1tm1Roml/Il1r1tm1Roml NOD.Cg-Il1r1tm1Roml MGI:3622312
cn6
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * C57BL/6 MGI:3850053
cx7
Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 MGI:5007930
cx8
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129S1/Sv * C57BL/6 MGI:5474283
cx9
Il1r1tm1Roml/Il1r1tm1Roml
Tg(KRT14-Il1f6)1Hblu/?
involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3762044


Genotype
MGI:3622351
hm1
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
C.Cg-Il1r1tm1Roml
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures
• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals
• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented
• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

hematopoietic system
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures
• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals
• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented
• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

cellular
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures




Genotype
MGI:3762043
hm2
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the skin of IMQ-treated mice
• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

skeleton
• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

integument
N
• mice have normal skin

hematopoietic system
• in the skin of IMQ-treated mice

homeostasis/metabolism
N
• IMQ-treated mice develop psoriasis as in wild-type mice




Genotype
MGI:3721963
hm3
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

homeostasis/metabolism
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

neoplasm
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

hematopoietic system
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired




Genotype
MGI:2179490
hm4
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice have reduced circulating levels of IL-6 after turpentine injection
• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection
• 50% reduction in paw swelling one day after injection in paw with methylated BSA
• fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta
• 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates

homeostasis/metabolism
• mice have reduced circulating levels of IL-6 after turpentine injection
• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection
• IL-1beta injection fails to increase body temperature




Genotype
MGI:3622312
hm5
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
NOD.Cg-Il1r1tm1Roml
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system
• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age
• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:87251




Genotype
MGI:3850053
cn6
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• postnatal lethality does not occur to mice on a IL-1 receptor null background

immune system
• variable skin inflammation is observed

integument
• variable skin inflammation is observed




Genotype
MGI:5007930
cx7
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Mefvtm5.1(MEFV)Chae mutation (0 available); any Mefv mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes
• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells




Genotype
MGI:5474283
cx8
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp1aNeut1/Nlrp1aNeut1
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Nlrp1aNeut1 mutation (0 available); any Nlrp1a mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• inflammatory disease does not develop
• increased sensitivity to lymphocytic choriomeningitis virus although virus titers remain like controls

hematopoietic system

homeostasis/metabolism
• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

mortality/aging
• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment




Genotype
MGI:3762044
cx9
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background
involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory