All Phenotypes Il1r1<tm1Roml> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il1r1^tm1Roml
targeted mutation 1, Mark A Labow
MGI:1857441

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1r1^tm1Roml/Il1r1^tm1Roml	C.Cg-Il1r1^tm1Roml	MGI:3622351
hm2	Il1r1^tm1Roml/Il1r1^tm1Roml	involves: 129S1/Sv	MGI:3762043
hm3	Il1r1^tm1Roml/Il1r1^tm1Roml	involves: 129S1/Sv * BALB/c	MGI:3721963
hm4	Il1r1^tm1Roml/Il1r1^tm1Roml	involves: 129S1/Sv * C57BL/6	MGI:2179490
hm5	Il1r1^tm1Roml/Il1r1^tm1Roml	NOD.Cg-Il1r1^tm1Roml	MGI:3622312
cn6	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp3^tm1Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129 * C57BL/6	MGI:3850053
cx7	Il1r1^tm1Roml/Il1r1^tm1Roml Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae}	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5007930
cx8	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S1/Sv * C57BL/6	MGI:5474283
cx9	Il1r1^tm1Roml/Il1r1^tm1Roml Tg(KRT14-Il1f6)1Hblu/?	involves: 129S1/Sv * C57BL/6 * DBA/2	MGI:3762044

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	C.Cg-Il1r1^tm1Roml

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:82863 )

• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

decreased eosinophil cell number ( J:82863 )

• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals

decreased T cell number ( J:82863 )

• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented

decreased immunoglobulin level ( J:82863 )

• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

hematopoietic system

decreased T cell proliferation ( J:82863 )

• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

decreased eosinophil cell number ( J:82863 )

• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals

decreased T cell number ( J:82863 )

decreased immunoglobulin level ( J:82863 )

• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

cellular

decreased T cell proliferation ( J:82863 )

• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

decreased susceptibility to induced arthritis ( J:120707 )

• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

skeleton

decreased susceptibility to induced arthritis ( J:120707 )

• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

integument

integument phenotype ( J:126327 )

N	• mice have normal skin

hematopoietic system

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:193548 )

N	• IMQ-treated mice develop psoriasis as in wild-type mice

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	involves: 129S1/Sv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

hematopoietic system

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-6 level ( J:42373 )

• mice have reduced circulating levels of IL-6 after turpentine injection

decreased circulating serum amyloid protein level ( J:42373 )

• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection

decreased susceptibility to type IV hypersensitivity reaction ( J:42373 )

• 50% reduction in paw swelling one day after injection in paw with methylated BSA

decreased interleukin-6 secretion ( J:42373 )

• fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta

increased susceptibility to bacterial infection ( J:42373 )

• 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:42373 )

• mice have reduced circulating levels of IL-6 after turpentine injection

decreased circulating serum amyloid protein level ( J:42373 )

• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection

impaired febrile response ( J:42373 )

• IL-1beta injection fails to increase body temperature

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	NOD.Cg-Il1r1^tm1Roml

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell death ( J:87251 )

• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system

decreased susceptibility to autoimmune diabetes ( J:87251 )

• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age

• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:87251

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp3^tm1Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nlrp3^tm1Hhf mutation (1 available); any Nlrp3 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:150054 )

N	• postnatal lethality does not occur to mice on a IL-1 receptor null background

immune system

skin inflammation ( J:150054 )

• variable skin inflammation is observed

integument

skin inflammation ( J:150054 )

• variable skin inflammation is observed

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae}
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Mefv^{tm5.1(MEFV)Chae} mutation (0 available); any Mefv mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172117 )

N	• mice do not exhibit inflammatory phenotypes observed in Mefv^{tm5.1(MEFV)Chae} homozygotes

increased interleukin-1 beta secretion ( J:172117 )

• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:191055 )

N	• inflammatory disease does not develop

abnormal leukopoiesis ( J:191055 )

abnormal leukocyte cell number ( J:191055 )

decreased eosinophil cell number ( J:191055 )

decreased lymphocyte cell number ( J:191055 )

decreased monocyte cell number ( J:191055 )

increased susceptibility to Riboviria infection ( J:191055 )

• increased sensitivity to lymphocytic choriomeningitis virus although virus titers remain like controls

hematopoietic system

abnormal leukopoiesis ( J:191055 )

thrombocytopenia ( J:191055 )

abnormal leukocyte cell number ( J:191055 )

decreased eosinophil cell number ( J:191055 )

decreased lymphocyte cell number ( J:191055 )

decreased monocyte cell number ( J:191055 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191055 )

• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191055 )

• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Tg(KRT14-Il1f6)1Hblu/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:126327 )

• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24