Phenotypes associated with this allele

• Allele Symbol: Sp4^tm1Ssp
• Allele Name: targeted mutation 1, S Steven Potter
• Allele ID: MGI:1857451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp4^tm1Ssp/Sp4^tm1Ssp	involves: 129P2/OlaHsd * CF-1	MGI:2669284

Genotype
MGI:2669284

hm1

• Allelic Composition: Sp4^tm1Ssp/Sp4^tm1Ssp
• Genetic Background: involves: 129P2/OlaHsd * CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:33573 )

• although apparently normal at birth, most homozygotes die within 2-3 days after birth of unknown causes; however, many of these dead pups contain milk in the stomachs

• only 30% of homozygotes survive up to 1 week of age

growth/size/body

decreased body size ( J:33573 )

• at >1 week of age, surviving homozygotes are significantly smaller than wild-type littermates

slow postnatal weight gain ( J:33573 )

• surviving homozygotes show a stunted growth rate during the first weeks of life but resume a normal growth rate after weaning

• however, homozygotes never attain a similar weight to controls as adults

behavior/neurological

reduced male mating frequency ( J:33573 )

♂ • male homozygotes fail to exhibit any mating behavior

♂ • no copulation plugs are observed even in matings with superovulated wild-type females

reproductive system

reproductive system phenotype ( J:33573 )

N • male homozygotes display normal testis, epididymis, vas deferens and prostate morphology

N • mutant testes appear histologically intact and contain mature sperm

male infertility ( J:33573 )

♂ • male homozygotes do not breed

♂ • in contrast, female homozygotes are fertile

nervous system

nervous system phenotype ( J:33573 )

N • newborn and surviving adult homozygotes display normal brain size and morphology relative to wild-type controls

N • mutant vomeronasal organs and hypothalami appear histologically normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:33573 )

N • mutant pituitary glands appear histologically normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:33573 )

N • homozygotes exhibit normal levels of serum insulin-like growth factor (IGF) binding proteins