All Phenotypes Srd5a1<tm1Mahe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Srd5a1^tm1Mahe
targeted mutation 1, Mala Mahendroo
MGI:1857454

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srd5a1^tm1Mahe/Srd5a1^tm1Mahe	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3029374
cx2	Srd5a1^tm1Mahe/Srd5a1^tm1Mahe Srd5a2^tm1Mahe/Srd5a2^tm1Mahe	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J	MGI:3029378

Allelic Composition	Srd5a1^tm1Mahe/Srd5a1^tm1Mahe
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srd5a1^tm1Mahe mutation (1 available); any Srd5a1 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal parturition ( J:32217 )

• 33% of homozygous female mice delivered litters on day 19 of gestation; the remainder exhibited prolonged labor, fetal death and often maternal death

decreased litter size ( J:32217 )

• homozygous female mice that delivered on day 19 of gestation had an average litter size of 3 pups vs. 8 pups in control females

Allelic Composition	Srd5a1^tm1Mahe/Srd5a1^tm1Mahe Srd5a2^tm1Mahe/Srd5a2^tm1Mahe
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srd5a1^tm1Mahe mutation (1 available); any Srd5a1 mutation (11 available)
Srd5a2^tm1Mahe mutation (0 available); any Srd5a2 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small prostate gland anterior lobe ( J:72807 )

small prostate gland ( J:72807 )

small seminal vesicle ( J:72807 )

reproductive system

small prostate gland anterior lobe ( J:72807 )

small prostate gland ( J:72807 )

small seminal vesicle ( J:72807 )

abnormal parturition ( J:72807 )

• described as similar to single mutation

decreased litter size ( J:72807 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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