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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il2rgtm1Wjl
targeted mutation 1, Warren J Leonard
MGI:1857455
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il2rgtm1Wjl/Il2rgtm1Wjl B6.129S4-Il2rgtm1Wjl/J MGI:3769353
cn2
 		B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5469014
cn3
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S4/SvJae * C57BL/6 MGI:5469012
cn4
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0 		involves: 129S4/SvJae * C57BL/6 MGI:5469013
cn5
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5469011
cx6
 		Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/? 		B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj MGI:4356292
cx7
 		Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl 		involves: 129S4/SvJae * C57BL/6 MGI:3624431
cx8
 		Il2rgtm1Wjl/Il2rgtm1Wjl
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129S/SvEv * 129S4/SvJae MGI:3817878
cx9
 		Del(7Pira1-Lilra6)1Fgla/Del(7Pira1-Lilra6)1Fgla
Il2rgtm1Wjl/Il2rgtm1Wjl
Rag2tm1Fwa/Rag2tm1Fwa 		involves: C57BL/6J * C57BL/6NTac MGI:6694871
cx10
 		Il2rgtm1Wjl/Il2rgtm1Wjl
Prkdcscid/Prkdcscid 		NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz MGI:3770657
cx11
 		Il2rgtm1Wjl/Y
Prkdcscid/Prkdcscid 		NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz MGI:3770662
cx12
 		Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom 		NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ MGI:3813939
ot13
 		Il2rgtm1Wjl/Y involves: 129S4/SvJae * C57BL/6 MGI:3624447


Genotype
MGI:3769353
hm1
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Genetic
Background		 B6.129S4-Il2rgtm1Wjl/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased myeloid dendritic cell number ( J:123902 )
• the proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen
abnormal splenic cell ratio ( J:123902 )
• reduced numbers of splenocytes
• decrease in the proportion and absolute number of CD11c+ dendritic cells in the spleen
abnormal dendritic cell physiology ( J:123902 )
• in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis
• bone marrow-derived dendritic cells overproduce IL12 and IL10

hematopoietic system
decreased myeloid dendritic cell number ( J:123902 )
• the proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen
abnormal splenic cell ratio ( J:123902 )
• reduced numbers of splenocytes
• decrease in the proportion and absolute number of CD11c+ dendritic cells in the spleen




Genotype
MGI:5469014
cn2
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469012
cn3
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice




Genotype
MGI:5469013
cn4
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:190889 )
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased NK T cell number ( J:190889 )
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469011
cn5
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:4356292
cx6
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:151722 )
N
• the presence of the transgene prevents the splenomegaly associated with Il2rgtm1Wjl homozygotes due to decreased lymphocyte numbers and size
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes




Genotype
MGI:3624431
cx7
Allelic
Composition		 Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (21 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

hematopoietic system
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

endocrine/exocrine glands
thymus hypoplasia ( J:108209 )
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls




Genotype
MGI:3817878
cx8
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:140483 )
• animals succumb to M. tuberculosis within 30 days, showing same median survival time as Ifng-null mice while wild-type survive infection for entire period of observation

immune system
abnormal interferon secretion ( J:140483 )
• cells do not produce any interferon gamma after incubation of splenocytes with mycobacteria
lung inflammation ( J:140483 )
• at 28 days post-infection (p.i.), lungs display massive lesions occupying about 60% of lung space compared to lungs in Rag2-null mice
increased susceptibility to bacterial infection ( J:140483 )
• mice are more susceptible to infection than Rag2-null single mutants and show similar survival time to Ifng-null mice
• in lungs and spleens of M. tuberculosis-infected mice at 28 days post-infection (p.i.), bacterial loads are >2 log higher than in infected wild-type mice

respiratory system
lung inflammation ( J:140483 )
• at 28 days post-infection (p.i.), lungs display massive lesions occupying about 60% of lung space compared to lungs in Rag2-null mice

hematopoietic system




Genotype
MGI:6694871
cx9
Allelic
Composition		 Del(7Pira1-Lilra6)1Fgla/Del(7Pira1-Lilra6)1Fgla
Il2rgtm1Wjl/Il2rgtm1Wjl
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7Pira1-Lilra6)1Fgla mutation (0 available); any Del(7Pira1-Lilra6)1Fgla mutation (0 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:290663 )
• no monocyte memory response to BALB/c allograft 7 or 28 days after priming with irradiated BALB/c splenocytes
• normal primary response (primary dendritic cell and macrophage functions) to BALB/c allograft after priming with irradiated BALB/c splenocytes




Genotype
MGI:3770657
cx10
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Prkdcscid/Prkdcscid
Genetic
Background		 NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
thymus cyst ( J:109833 )
• sporadic cyst structures

mortality/aging
premature death ( J:109833 )
• median survival time is lengthened to between 59-95 weeks (median 89 weeks) in contrast to the shorter lifespan observed homozygous Prkdcscid controls
• the majority of autopsies indicate no evidence of lymphomas

immune system
decreased leukocyte cell number ( J:109833 )
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
decreased immature B cell number ( J:109833 )
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
decreased mature B cell number ( J:109833 )
• spleens are deficient in B220+ IgK+ B cells
decreased NK cell number ( J:109833 )
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
decreased CD4-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased CD8-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased immunoglobulin level ( J:109833 )
• no detectable immunoglobulin in mice at 394-426 days of age
abnormal immune system organ morphology ( J:109833 )
• lymph tissues are severely depleted of lymphoid cells
abnormal thymus morphology ( J:109833 )
• thymus consists mostly of stromal cells with sporadic cyst structures
thymus cyst ( J:109833 )
• sporadic cyst structures
decreased spleen B cell follicle number ( J:109833 )
• spleens do not have detectable follicles
abnormal splenic cell ratio ( J:109833 )
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
small lymph nodes ( J:109833 )
• lymph nodes in the double mutant are markedly smaller than those of homozygous Prkdcscid mice
lymph node hypoplasia ( J:109833 )
• lymph nodes are hypocellular
abnormal response to transplant ( J:109833 )
• mice support CD34+ human stem cell engraftment at much higher levels than Prkdcscid controls
• human CD45+ cells comprise almost 50% of cells in the spleen, approximately 35% in bone marrow and thymus, and 6% in blood at 10 weeks post-engraftment

hematopoietic system
abnormal thymus morphology ( J:109833 )
• thymus consists mostly of stromal cells with sporadic cyst structures
thymus cyst ( J:109833 )
• sporadic cyst structures
decreased mean corpuscular volume ( J:109833 )
• slight decrease in packed cell volume at 10 weeks as compared to to Prkdcscid controls
decreased leukocyte cell number ( J:109833 )
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
decreased immature B cell number ( J:109833 )
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
decreased mature B cell number ( J:109833 )
• spleens are deficient in B220+ IgK+ B cells
decreased NK cell number ( J:109833 )
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
decreased CD4-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased CD8-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased spleen B cell follicle number ( J:109833 )
• spleens do not have detectable follicles
abnormal splenic cell ratio ( J:109833 )
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
decreased immunoglobulin level ( J:109833 )
• no detectable immunoglobulin in mice at 394-426 days of age

cellular
increased cellular sensitivity to X-ray irradiation ( J:109833 )
• mice do not survive doses above or equal to 400cGy

neoplasm
decreased incidence of tumors by ionizing radiation induction ( J:109833 )
• mice irradiated with doses below 400cGy do not exhibit thymic lymphomas in contrast to homozygous Prkdcscid controls

homeostasis/metabolism
abnormal glucose homeostasis ( J:138005 )
• streptozotocin-diabetic mice are not restored to euglycemia after receiving transplants of 1000 to 3000 IEQ, while 4000 IEQ transplant was successful in two long-term survivors
hyperglycemia ( J:138005 )
• streptozotocin effectively induced hyperglycemia essentially equally in male and female mice at doses of 120to 160 mg/kg; some mice do not become hyperglycemic at all doses of streptozotocin administered

endocrine/exocrine glands
abnormal thymus morphology ( J:109833 )
• thymus consists mostly of stromal cells with sporadic cyst structures
thymus cyst ( J:109833 )
• sporadic cyst structures




Genotype
MGI:3770662
cx11
Allelic
Composition		 Il2rgtm1Wjl/Y
Prkdcscid/Prkdcscid
Genetic
Background		 NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:109833 )
• the majority of autopsies indicate no evidence of lymphomas
• median survival time is lengthened to between 59-95 weeks (median 89 weeks) in contrast to the shorter lifespan observed homozygous Prkdcscid controls

cellular
increased cellular sensitivity to X-ray irradiation ( J:109833 )
• mice do not survive doses above or equal to 400cGy

hematopoietic system
abnormal thymus morphology ( J:109833 )
• thymus consists mostly of stromal cells with sporadic cyst structures
decreased mean corpuscular volume ( J:109833 )
• slight decrease in packed cell volume at 10 weeks as compared to to Prkdcscid controls
decreased leukocyte cell number ( J:109833 )
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
decreased immature B cell number ( J:109833 )
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
decreased mature B cell number ( J:109833 )
• spleens are deficient in B220+ IgK+ B cells
decreased NK cell number ( J:109833 )
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
decreased CD4-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased CD8-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased spleen B cell follicle number ( J:109833 )
• spleens do not have detectable follicles
abnormal splenic cell ratio ( J:109833 )
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
decreased immunoglobulin level ( J:109833 )
• no detectable immunoglobulin in mice at 394-426 days of age

immune system
decreased leukocyte cell number ( J:109833 )
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
decreased immature B cell number ( J:109833 )
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
decreased mature B cell number ( J:109833 )
• spleens are deficient in B220+ IgK+ B cells
decreased NK cell number ( J:109833 )
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
decreased CD4-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased CD8-positive, alpha-beta T cell number ( J:109833 )
• spleens are deficient in mature T cells
decreased immunoglobulin level ( J:109833 )
• no detectable immunoglobulin in mice at 394-426 days of age
abnormal immune system organ morphology ( J:109833 )
• lymph tissues are severely depleted of lymphoid cells
abnormal thymus morphology ( J:109833 )
• thymus consists mostly of stromal cells with sporadic cyst structures
decreased spleen B cell follicle number ( J:109833 )
• spleens do not have detectable follicles
abnormal splenic cell ratio ( J:109833 )
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
small lymph nodes ( J:109833 )
• lymph nodes in the double mutant are markedly smaller than those of homozygous Prkdcscid mice
lymph node hypoplasia ( J:109833 )
• lymph nodes are hypocellular
abnormal response to transplant ( J:109833 , J:140388 )
• mice support CD34+ human stem cell engraftment at much higher levels than Prkdcscid controls (J:109833)
• human CD45+ cells comprise almost 50% of cells in the spleen, approximately 35% in bone marrow and thymus, and 6% in blood at 10 weeks post-engraftment (J:109833)
• irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1tm1Mom homozygotes (J:140388)
• percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.CB17-Prkdcscid mice (J:140388)
• levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.CB17-Prkdcscid mice (J:140388)
• CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.CB17-Prkdcscid mice (J:140388)
• engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.CB17-Prkdcscid (J:140388)

endocrine/exocrine glands
abnormal thymus morphology ( J:109833 )
• thymus consists mostly of stromal cells with sporadic cyst structures




Genotype
MGI:3813939
cx12
Allelic
Composition		 Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
thymus cyst ( J:140388 )
• thymus contains large cysts

immune system
abnormal thymus morphology ( J:140388 )
• no lymphoid cells are present
absent thymus cortex ( J:140388 )
• no defined cortical region is observed
absent thymus medulla ( J:140388 )
• no defined medullary region is observed
thymus cyst ( J:140388 )
• thymus contains large cysts
absent NK T cells ( J:140388 )
• natural killer cell (NK; DX5+LGL+ cells) are absent
decreased macrophage cell number ( J:140388 )
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
abnormal spleen morphology ( J:140388 )
• spleen contains mainly myeloid-like cells and few lymphoid cells
decreased spleen B cell follicle number ( J:140388 )
• spleen contains no follicles (or germinal centers)
abnormal adaptive immunity ( J:140388 )
• mature T and B cell populations are absent
• there are diminished CD3+CD4+ and CD3+CD8+ T cells and Igk+ light chain+ B cells in the spleen
abnormal innate immunity ( J:140388 )
• cells functioning in innate immunity are severely decreased in number
abnormal response to transplant ( J:140388 )
• irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1tm1Mom homozygotes
• percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.129S7(B6)-Rag1tm1Mom homozygotes
• levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.129S7(B6)-Rag1tm1Mom mice
• CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.129S7(B6)-Rag1tm1Mom mice
• engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.129S7(B6)-Rag1tm1Mom mice

hematopoietic system
abnormal thymus morphology ( J:140388 )
• no lymphoid cells are present
absent thymus cortex ( J:140388 )
• no defined cortical region is observed
absent thymus medulla ( J:140388 )
• no defined medullary region is observed
thymus cyst ( J:140388 )
• thymus contains large cysts
absent NK T cells ( J:140388 )
• natural killer cell (NK; DX5+LGL+ cells) are absent
decreased macrophage cell number ( J:140388 )
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
abnormal spleen morphology ( J:140388 )
• spleen contains mainly myeloid-like cells and few lymphoid cells
decreased spleen B cell follicle number ( J:140388 )
• spleen contains no follicles (or germinal centers)

endocrine/exocrine glands
abnormal thymus morphology ( J:140388 )
• no lymphoid cells are present
absent thymus cortex ( J:140388 )
• no defined cortical region is observed
absent thymus medulla ( J:140388 )
• no defined medullary region is observed
thymus cyst ( J:140388 )
• thymus contains large cysts




Genotype
MGI:3624447
ot13
Allelic
Composition		 Il2rgtm1Wjl/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
cecum inflammation ( J:24117 )
• cecum inflammation is visible in the lamina propia
decreased double-negative T cell number ( J:24117 )
• there is a reduced number of double-positive T cells in the thymus
decreased double-positive T cell number ( J:24117 )
• there is a reduced number of double-negative T cells in the thymus
abnormal B cell number ( J:108209 )
• after treatment with anti-Tpte, null mice show increased numbers of B cells in the spleen which contribute to the increased splenic cellularity
decreased immature B cell number ( J:24117 )
• absolute numbers are reduced in the spleen
absent NK cells ( J:24117 )
• NK1.1 positive cells are not detected
decreased CD8-positive, alpha-beta T cell number ( J:24117 )
• 10- to 20- fold drop in percentage of CD8 positive T cells found in three week old spleen
• percentages of CD8 positive T cells in spleen return to normal by 9 weeks of age
absent gamma-delta T cells ( J:24117 )
• no gamma-delta T cells are found in the thymus or the skin
absent gamma-delta intraepithelial T cell ( J:24117 )
• no gamma-delta IEL are found in the intestine
decreased single-positive T cell number ( J:24117 )
• there is a reduced number of single-postive T cells in the thymus
abnormal CD4-positive, alpha beta T cell morphology ( J:108209 )
• when Tpte-deficient CD4+ T cells are injected into irradiated knockouts, transferred cells exhibit less expansion compared to wild-type CD4+ T cells
small thymus cortex ( J:24117 )
• cortex is reduced in size
thymus hyperplasia ( J:108209 )
• after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts
small thymus ( J:24117 )
• thymus is very small
spleen hyperplasia ( J:24117 )
• about a 2 fold increase in cellularity at nine weeks of age
spleen hypoplasia ( J:24117 )
• about a 10 fold reduction in cellularity at three weeks of age
abnormal gut-associated lymphoid tissue morphology ( J:24117 )
• gut associated lymphoid tissue was absent in the small and large intestine
abnormal mesenteric lymph node morphology ( J:24117 )
• small, with few follicles and no germinal centers
small lymph nodes ( J:24117 )
• peripheral lymph nodes are not identifiable
decreased T cell proliferation ( J:24117 )
• less potent proliferation of splenic T cells to mitogen stimulation
abnormal thymocyte activation ( J:24117 )
• marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation
abnormal basophil physiology ( J:24117 )
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
abnormal mast cell physiology ( J:24117 )
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
impaired natural killer cell mediated cytotoxicity ( J:24117 )
• no NK cytolytic acitivity detected
decreased immunoglobulin level ( J:24117 )
• concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice
decreased interferon-gamma secretion ( J:24117 )
• IFN-gamma production by stimulated T cells is reduced by a 1000 fold
decreased interleukin-2 secretion ( J:24117 )
• production of IL-2 by stimulated T cells is reduced by about 40%
decreased interleukin-4 secretion ( J:24117 )
• production of IL-4 by stimulated T cells is reduced by about 40%

digestive/alimentary system
abnormal cecum morphology ( J:24117 )
• crypt height is increased and inflammation is visible in the lamina propia
cecum inflammation ( J:24117 )
• cecum inflammation is visible in the lamina propia

hematopoietic system
decreased T cell proliferation ( J:24117 )
• less potent proliferation of splenic T cells to mitogen stimulation
small thymus cortex ( J:24117 )
• cortex is reduced in size
thymus hyperplasia ( J:108209 )
• after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts
small thymus ( J:24117 )
• thymus is very small
abnormal thymocyte activation ( J:24117 )
• marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation
spleen hyperplasia ( J:24117 )
• about a 2 fold increase in cellularity at nine weeks of age
decreased double-negative T cell number ( J:24117 )
• there is a reduced number of double-positive T cells in the thymus
decreased double-positive T cell number ( J:24117 )
• there is a reduced number of double-negative T cells in the thymus
abnormal B cell number ( J:108209 )
• after treatment with anti-Tpte, null mice show increased numbers of B cells in the spleen which contribute to the increased splenic cellularity
decreased immature B cell number ( J:24117 )
• absolute numbers are reduced in the spleen
absent NK cells ( J:24117 )
• NK1.1 positive cells are not detected
decreased CD8-positive, alpha-beta T cell number ( J:24117 )
• 10- to 20- fold drop in percentage of CD8 positive T cells found in three week old spleen
• percentages of CD8 positive T cells in spleen return to normal by 9 weeks of age
absent gamma-delta T cells ( J:24117 )
• no gamma-delta T cells are found in the thymus or the skin
absent gamma-delta intraepithelial T cell ( J:24117 )
• no gamma-delta IEL are found in the intestine
decreased single-positive T cell number ( J:24117 )
• there is a reduced number of single-postive T cells in the thymus
abnormal CD4-positive, alpha beta T cell morphology ( J:108209 )
• when Tpte-deficient CD4+ T cells are injected into irradiated knockouts, transferred cells exhibit less expansion compared to wild-type CD4+ T cells
spleen hypoplasia ( J:24117 )
• about a 10 fold reduction in cellularity at three weeks of age
abnormal basophil physiology ( J:24117 )
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
abnormal mast cell physiology ( J:24117 )
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
decreased immunoglobulin level ( J:24117 )
• concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice
impaired natural killer cell mediated cytotoxicity ( J:24117 )
• no NK cytolytic acitivity detected

endocrine/exocrine glands
small thymus cortex ( J:24117 )
• cortex is reduced in size
thymus hyperplasia ( J:108209 )
• after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts
small thymus ( J:24117 )
• thymus is very small
abnormal thymocyte activation ( J:24117 )
• marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation

growth/size/body
spleen hyperplasia ( J:24117 )
• about a 2 fold increase in cellularity at nine weeks of age

cellular
decreased T cell proliferation ( J:24117 )
• less potent proliferation of splenic T cells to mitogen stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory