Phenotypes associated with this allele

• Allele Symbol: Adra2a^tm1Lel
• Allele Name: targeted mutation 1, Lee E Limbird
• Allele ID: MGI:1857459
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adra2a^tm1Lel/Adra2a^tm1Lel	involves: 129S2/SvPas * C57BL/6	MGI:3620525

Genotype
MGI:3620525

hm1

• Allelic Composition: Adra2a^tm1Lel/Adra2a^tm1Lel
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal systemic arterial blood pressure ( J:34820 )

• homozygotes are viable and exhibit normal baseline blood pressure and heart rate relative to wild-type mice

• however, unlike wild-type mice, homozygotes fail to exhibit an immediate (transient) hypertensive response after femoral administration of alpha2AR agonist UK14,304

• in addition, homozygotes fail to exhibit a subsequent hypotensive response to alpha2AR agonists, independent of the agonist used (UK14,304 or dexmedetomidine) or the site of agonist infusion (carotid or femoral)