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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grprtm1Jfb
targeted mutation 1, James F Battey
MGI:1857462
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grprtm1Jfb/Grprtm1Jfb involves: 129X1/SvJ * C57BL/6J MGI:2176820
cn2
 		Braftm1Cpri/Braf+
Grprtm1Jfb/?
Scn10atm2(cre)Jwo/Scn10a+ 		involves: 129 * 129P2/OlaHsd * 129X1/SvJ MGI:5565457
cn3
 		Grprtm1Jfb/Grprtm1Jfb
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Thtm1(cre)Te/Th+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887830
cx4
 		Grprtm1Jfb/Grprtm1Jfb
Nmbrtm1Hoh/Nmbrtm1Hoh 		involves: 129P2/OlaHsd * 129X1/SvJ MGI:6111349
ot5
 		Grprtm1Jfb/Y involves: 129X1/SvJ * C57BL/6J MGI:2176819


Genotype
MGI:2176820
hm1
Allelic
Composition		 Grprtm1Jfb/Grprtm1Jfb
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation (1 available); any Grpr mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:46897 )
• female homozygotes are viable, fertile and developmentally normal with no pathological or histological abnormalities in all major organ systems up to 10 months of age




Genotype
MGI:5565457
cn2
Allelic
Composition		 Braftm1Cpri/Braf+
Grprtm1Jfb/?
Scn10atm2(cre)Jwo/Scn10a+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Cpri mutation (0 available); any Braf mutation (60 available)
Grprtm1Jfb mutation (1 available); any Grpr mutation (14 available)
Scn10atm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:205122 )
N
• spontaneous scratching, seen in mutant mice wild-type for Grpr, is markedly diminished




Genotype
MGI:4887830
cn3
Allelic
Composition		 Grprtm1Jfb/Grprtm1Jfb
Slc17a6tm1Kldr/Slc17a6tm1Kldr
Thtm1(cre)Te/Th+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation (1 available); any Grpr mutation (14 available)
Slc17a6tm1Kldr mutation (1 available); any Slc17a6 mutation (60 available)
Thtm1(cre)Te mutation (1 available); any Th mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
excessive scratching ( J:167752 )
• compound mutant mice show elevated scratching compared to wild-type but this is significantly reduced from that shown by mutants with intact Grpr function




Genotype
MGI:6111349
cx4
Allelic
Composition		 Grprtm1Jfb/Grprtm1Jfb
Nmbrtm1Hoh/Nmbrtm1Hoh
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation (1 available); any Grpr mutation (14 available)
Nmbrtm1Hoh mutation (0 available); any Nmbr mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:253572 )
N
• mice exhibit normal responses to a wide array of noxious stimuli




Genotype
MGI:2176819
ot5
Allelic
Composition		 Grprtm1Jfb/Y
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation (1 available); any Grpr mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal food intake ( J:46897 )
• male hemizygotes are viable, fertile and developmentally normal with no pathological or histological abnormalities in all major organ systems up to 10 months of age
• however, male hemizygotes lack a bombesin (BN)-induced satiety response: BN produces a significant suppression of glucose intake in wild-type mice at doses of 3.2, 10, and 32 nmol/kg but fails to suppress glucose intake at any dose with no apparent weight gain in mutant males




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory