Phenotypes associated with this allele

• Allele Symbol: Gck^tm1Ts
• Allele Name: targeted mutation 1, Timothy Stewart
• Allele ID: MGI:1857469
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^tm1Ts/Gck^tm1Ts	either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)	MGI:2176947
ht2	Gck^tm1Ts/Gck^+	either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)	MGI:2176950

Genotype
MGI:2176947

hm1

• Allelic Composition: Gck^tm1Ts/Gck^tm1Ts
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:29255 )

• death between postnatal days 3 and 5 (P3 - P5)

• cessation of feeding postnatal day 3 (P3)

liver/biliary system

decreased liver glycogen level ( J:29255 )

• reduction in liver glycogen stores

microvesicular hepatic steatosis ( J:29255 )

• microvesicular steatosis (vacuolization and lipid accumulation)

homeostasis/metabolism

abnormal circulating cholesterol level ( J:29255 )

• increased serum concentration of cholesterol

increased circulating triglyceride level ( J:29255 )

• increased serum concentrations of triglycerides

decreased liver glycogen level ( J:29255 )

• reduction in liver glycogen stores

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:29255

Genotype
MGI:2176950

ht2

• Allelic Composition: Gck^tm1Ts/Gck⁺
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)

homeostasis/metabolism

hyperglycemia ( J:29255 )

• hyperglycemia in fed and fasted states; normal insulin levels observed

impaired glucose tolerance ( J:29255 )

• decreased glucose tolerance shown in glucose tolerance tests

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:29255