Phenotypes associated with this allele

• Allele Symbol: Cyp2e1^tm1Gonz
• Allele Name: targeted mutation 1, Frank J Gonzalez
• Allele ID: MGI:1857483
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz	involves: 129S4/SvJae	MGI:3834983
hm2	Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz	involves: 129S4/SvJae * C57BL/6N	MGI:3834976
cx3	Cyp1a2^tm1Gonz/Cyp1a2^tm1Gonz Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz	involves: 129S4/SvJae	MGI:3043021

Genotype
MGI:3834983

hm1

• Allelic Composition: Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:143909 )

• allylnitrile-treated mice exhibit reduced mortality compared to similarly treated mice and this mortality is not affected by pretreatment with acetone or treatment with diallylsulfide

homeostasis/metabolism

abnormal blood homeostasis ( J:143909 )

• allylnitrile-treated mice exhibit increased serum levels of allylnitrile and cyanide compared to similarly treated wild-type mice

abnormal physiological response to xenobiotic ( J:143909 )

• allylnitrile-treated mice exhibit reduced mortality compared to similarly treated mice and this mortality is not affected by pretreatment with acetone or treatment with diallylsulfide

increased susceptibility to xenobiotic induced morbidity/mortality ( J:143909 )

• allylnitrile-treated mice exhibit reduced mortality compared to similarly treated mice and this mortality is not affected by pretreatment with acetone or treatment with diallylsulfide

decreased incidence of tumors by chemical induction ( J:118150 )

• urethane-treated mice exhibit fewer hepatocellullar hypertrophies, hemangiomas, hemangiosarcomas, Harderian gland hyperplasias and adenomas, and lung tumors than in similarly treated wild-type mice

abnormal xenobiotic pharmacokinetics ( J:143909 )

• allylnitrile-treated mice exhibit increased serum levels of allylnitrile and cyanide compared to similarly treated wild-type mice

liver/biliary system

abnormal hepatocyte morphology ( J:118150 )

• urethane-treated mice exhibit fewer hepatcellular hypertrophies than in similarly treated wild-type mice

hepatic steatosis ( J:112076 )

• when fed a methionine- and choline-deficient diet, mice exhibit increased hepatic fat accumulation compared to similarly treated wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:118150 )

• urethane-treated mice exhibit fewer hepatocellullar hypertrophies, hemangiomas, hemangiosarcomas, Harderian gland hyperplasias and adenomas, and lung tumors than in similarly treated wild-type mice

cardiovascular system

dilated vasculature ( J:118150 )

• urethane-treated mice exhibit fewer incidents of angiectasis compared to in similarly treated wild-type mice

behavior/neurological

enhanced behavioral response to xenobiotic ( J:143909 )

• allylnitrile-treated mice exhibit greater loss of vestibular function than similarly treated wild-type mice

• cotreatment with aminobenzotriazole but not with diallysulfide prevents the vestibular toxicity

Genotype
MGI:3834976

hm2

• Allelic Composition: Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz
• Genetic Background: involves: 129S4/SvJae * C57BL/6N

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:48196 )

• mice are more resistant to acetaminophen toxicity than wild-type mice

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:48196 )

• mice are more resistant to acetaminophen toxicity than wild-type mice

decreased physiological sensitivity to xenobiotic ( J:48196 )

• following administration of 200 and 400 mg/kg acetaminophen, mice exhibit unaltered levels of serum liver enzymes unlike wild-type mice and reduced liver damage compared to similarly treated wild-type mice

Genotype
MGI:3043021

cx3

• Allelic Composition: Cyp1a2^tm1Gonz/Cyp1a2^tm1Gonz; Cyp2e1^tm1Gonz/Cyp2e1^tm1Gonz
• Genetic Background: involves: 129S4/SvJae

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:81117 )

• highly resistant to acetaminophen (APAP)-induced hepatotoxicity relative to wild-type mice

• administration of 600 to 800 mg/kg of APAP to double mutant males resulted in normal plasma levels of liver enzymes and normal liver histopathology; in contrast, wild-type males exhibited increased plasma concentrations of liver enzymes, lipidosis, liver necrosis, and renal tubular necrosis

• administration of 1200 mg of APAP/kg to double homozygotes resulted in occasional liver lipidosis and mild kidney lesions

• double homozygotes displayed a significant delay in the depletion of hepatic glutathione and lacked APAP covalent binding to hepatic cytosolic proteins