All Phenotypes Otx2<tm1Pas> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm1Pas/Otx2^tm1Pas	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:2169103
ht2	Otx2^tm1Pas/Otx2⁺	involves: C57BL/6 * FVB/N	MGI:5571298
ht3	Otx2^tm1Pas/Otx2^tm2Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845514
cx4	Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Otx2^tm1Pas/Otx2^tm2Asim	involves: 129 * C57BL/6 * DBA/2	MGI:3845546
cx5	Otx1^tm1Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845768
cx6	Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3578521
cx7	Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845769

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:29276 )

• lethality after E9.5 but before birth

growth/size/body

embryonic growth retardation ( J:29276 )

• less affected embryos are delayed in development such that E9.5 embryos resemble E8.5 embryos

decreased embryo size ( J:29276 )

• smaller at E8.5

embryo

abnormal developmental patterning ( J:29276 )

• severely affected embryos show a completely abnormal body plan at E9.5

abnormal mesoderm development ( J:29276 )

• exhibit disorganization of the forming mesoderm at E7.5

rostral body truncation ( J:29276 )

• exhibit deletion of the anterior structures

embryonic growth retardation ( J:29276 )

• less affected embryos are delayed in development such that E9.5 embryos resemble E8.5 embryos

decreased embryo size ( J:29276 )

• smaller at E8.5

abnormal embryonic tissue morphology ( J:29276 )

• the presumptive embryonic structures (containing the ectoderm) are reduced in size and appear as a sphere, linked to the proximal region by a constriction at E7.5

absent pharyngeal arches ( J:29276 )

• branchial arches are not seen at E9.5

abnormal neural tube morphology ( J:29276 )

• anterior parts of the neural tube are absent, however regions of the neural tube fated to the spinal cord are present

abnormal primitive node morphology ( J:29276 )

• the node structure is not recognized at the end of gastrulation and formation is altered as early as the early streak stage as shown by the absence or strong reduction of goosecoid expression

abnormal somite development ( J:29276 )

• somites of less affected embryos are disorganized

abnormal somite shape ( J:29276 )

• somites of less affected embryos are irregular in shape

abnormal amnion morphology ( J:29276 )

• amnion is not clearly individualized, making the embryonic-extraembryonic junction difficult to delineate at E7.5

nervous system

abnormal neural tube morphology ( J:29276 )

• anterior parts of the neural tube are absent, however regions of the neural tube fated to the spinal cord are present

abnormal hindbrain development ( J:29276 )

• severely affected embryos do not show the typical hindbrain morphology and no evidence of segmentation, however in less affected mutants, the hindbrain region is present

absent midbrain ( J:29276 )

• absence of midbrain regions by E9.5

absent forebrain ( J:29276 )

• deletion of forebrain neuroepithelium

cardiovascular system

small heart ( J:29276 )

craniofacial

absent nasal placodes ( J:29276 )

• olfactory placodes are absent at E9

absent pharyngeal arches ( J:29276 )

• branchial arches are not seen at E9.5

taste/olfaction

absent nasal placodes ( J:29276 )

• olfactory placodes are absent at E9

vision/eye

absent optic vesicle ( J:29276 )

• optic vesicles are not seen at E9.5

respiratory system

absent nasal placodes ( J:29276 )

• olfactory placodes are absent at E9

Allelic Composition	Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:210118 )

• female mice are not born or do not survive to weaning

reproductive system

decreased testis weight ( J:210118 )

decreased litter size ( J:210118 )

• from male heterozygotes bred with wild-type female mice

reduced male fertility ( J:210118 )

nervous system

abnormal gonadotroph morphology ( J:210118 )

• at E17.5 and 3 months, GnRH+ neuronal terminals are reduced at the median eminence compared to in wild-type mice

decreased gonadotroph cell number ( J:210118 )

• in the nose, cribiform plate and brain at E13.5

• in the brain at E17.5

• however, numbers are normal at a later stage of development

homeostasis/metabolism

decreased circulating luteinizing hormone level ( J:210118 )

endocrine/exocrine glands

abnormal gonadotroph morphology ( J:210118 )

• at E17.5 and 3 months, GnRH+ neuronal terminals are reduced at the median eminence compared to in wild-type mice

decreased gonadotroph cell number ( J:210118 )

• in the nose, cribiform plate and brain at E13.5

• in the brain at E17.5

• however, numbers are normal at a later stage of development

decreased testis weight ( J:210118 )

Allelic Composition	Otx2^tm1Pas/Otx2^tm2Asim
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)
Otx2^tm2Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:71034 , J:72725 )

• at E10.5, 90% of mice exhibit severe and 10% moderate reductions in the rostral central nervous system (J:71034)

• at E8.7, mice lack anterior neural tissue (J:72725)

abnormal forebrain development ( J:71034 )

• while forebrain territory is initially established it is not properly maintained

abnormal midbrain development ( J:71034 )

• while midbrain territory is initially established it is not properly maintained

embryo

abnormal first pharyngeal arch morphology ( J:71034 )

• all mice exhibit abnormalities in the mandibular arch and its derivatives

craniofacial

abnormal maxillary prominence morphology ( J:71034 )

• all mice exhibit abnormalities in the maxillary process and its derivatives

abnormal first pharyngeal arch morphology ( J:71034 )

• all mice exhibit abnormalities in the mandibular arch and its derivatives

growth/size/body

acephaly ( J:71034 , J:72725 )

• at E16, 90% of embryos exhibit an almost headless phenotype with a morphologically undefined neural structure (J:71034)

• embryos are almost headless (J:72725)

Allelic Composition	Gbx2^tm1.1Mrt/Gbx2^tm1.1Mrt Otx2^tm1Pas/Otx2^tm2Asim
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2^tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)
Otx2^tm2Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:72725 )

N	• mice are viable at E10.5

nervous system

abnormal brain development ( J:72725 )

• brain development is compromised

• however, mice exhibit rescue of the anterior defects observed in Otx2^{tm1(OTX1)Asim}/Otx2^tm1Pas heterozygotes

cardiovascular system

cardiovascular system phenotype ( J:72725 )

N	• heart development is normal

growth/size/body

abnormal head development ( J:72725 )

• head development is compromised

Allelic Composition	Otx1^tm1Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm1Asim mutation (2 available); any Otx1 mutation (86 available)
Otx1^tm2(otd)Asim mutation (1 available); any Otx1 mutation (86 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:47899 )

• mice die at birth

nervous system

abnormal brain morphology ( J:47899 )

• mice exhibit abnormal brain morphology

• however, the dorsal thalamus, Ammon's horn, and pretectum absent in Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺ are restored

abnormal midbrain morphology ( J:47899 )

• mice exhibit abnormal mesencephalic morphology with a reduction in thickness of the alar region compared to in wild-type mice

abnormal cerebellum morphology ( J:47899 )

Allelic Composition	Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm1Asim mutation (2 available); any Otx1 mutation (86 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:88192 )

abnormal dopaminergic neuron morphology ( J:88192 )

• dopaminergic domain shifted rostrally into the diencephalon at E12.5 and E15.5

abnormal serotonergic neuron morphology ( J:88192 )

• serotonergic neuron domain expands rostrally to the diencephalon at E12.5 and E15.5

Allelic Composition	Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm2(otd)Asim mutation (1 available); any Otx1 mutation (86 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal midbrain morphology ( J:47899 )

• mice exhibit severe perturbation in the posterior mesencephalon

• however, mice exhibit an improvement in the dorsal thalamus, pretectal area, and anterior mesencephalon morphology compared to in Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺

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